CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota

[en] Interleukin-17-producing γδ T (γδ17) cells play a central role in protective and pathogenic immune responses. However, the tissue-specific mechanisms that control the activation of these innate lymphocytes are not known. Here, we demonstrate that CD109, a glycosylphosphatidylinositol (GPI)-anchored protein highly expressed by keratinocytes, is an important regulator of skin homeostasis and γδ17 cell activation. Genetic deletion of CD109 results in spontaneous epidermal hyperplasia, aberrant accumulation of dermal-derived γδ17 cells, and enhanced susceptibility to psoriasiform inflammation. In this context, γδ17 activation requires interleukin (IL)-23 signals and is reversed by transient depletion of the skin microbiota. Mechanistically, CD109 restrains γδ17 cell activation in a cell-extrinsic manner by fortifying skin barrier integrity. Collectively, our data provide insight into the regulation of the skin IL-23/IL-17 immune axis and how homeostasis is maintained at this important barrier site.

Disciplines :

Immunology & infectious disease

Author, co-author :

Zhang, Hualin

Carnevale, Guistino

Polese, Barbara ; Université de Liège - ULiège > I3-Cellular and Molecular Immunology

Simard, M

Thurairajah, Bavanitha

Khan, N

Gentile, M E

Fontes, Ghislaine

Vinh, D C

Pouliot, R

King, Irah; McGill University - McGill

Language :

English

Title :

CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota

Publication date :

October 2019

Journal title :

Cell Reports

eISSN :

2211-1247

Publisher :

Elsevier, Amsterdam, Netherlands

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 June 2020

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