Article (Scientific journals)
EMT-Associated Heterogeneity in Circulating Tumor Cells : Sticky Friends on the Road to Metastasis
Genna, Anthony; Vanwynsberghe, Aline; Villard, Amélie et al.
2020In Cancers, 12 (6), p. 1632
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Keywords :
EMT; CTC; coagulation; early metastasis; heterogeneity
Abstract :
[en] Epithelial-Mesenchymal Transitions (EMTs) generate hybrid phenotypes with enhanced ability to adapt to diverse microenvironments encountered during the metastatic spread. EMTs accordingly play crucial role in the biology of Circulating Tumor Cells (CTCs) and contribute to their heterogeneity. We here review major EMT-driven properties that may help hybrid E/M CTCs to survive in the bloodstream and accomplish early phases of metastatic colonization. We then discuss how interrogating EMT in CTCs as a companion biomarker could help refine cancer patient management, supporting further the relevance of CTCs in personalized medicine.
Disciplines :
Oncology
Author, co-author :
Genna, Anthony  ;  Université de Liège - ULiège > Cancer-Tumours and development biology
Vanwynsberghe, Aline  ;  Université de Liège - ULiège > Cancer-Tumours and development biology
Villard, Amélie   ;  Université de Liège - ULiège > Cancer-Tumours and development biology
POTTIER, Charles  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses - médecine interne
Ancel, Julien
Polette, Myriam
Gilles, Christine ;  Université de Liège - ULiège > Cancer-Tumours and development biology
 These authors have contributed equally to this work.
Language :
English
Title :
EMT-Associated Heterogeneity in Circulating Tumor Cells : Sticky Friends on the Road to Metastasis
Publication date :
2020
Journal title :
Cancers
eISSN :
2072-6694
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
12
Issue :
6
Pages :
1632
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 June 2020

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