EMT-Associated Heterogeneity in Circulating Tumor Cells : Sticky Friends on the Road to Metastasis

Genna, Anthony; Vanwynsberghe, Aline; Villard, Amélie; POTTIER, Charles; Ancel, Julien; Polette, Myriam; Gilles, Christine

doi:10.3390/cancers12061632

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EMT-Associated Heterogeneity in Circulating Tumor Cells : Sticky Friends on the Road to Metastasis

Genna, Anthony; Vanwynsberghe, Aline; Villard, Amélie et al.

2020 • In Cancers, 12 (6), p. 1632

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10.3390/cancers12061632

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Keywords :

EMT; CTC; coagulation; early metastasis; heterogeneity

Abstract :

[en] Epithelial-Mesenchymal Transitions (EMTs) generate hybrid phenotypes with enhanced ability to adapt to diverse microenvironments encountered during the metastatic spread. EMTs accordingly play crucial role in the biology of Circulating Tumor Cells (CTCs) and contribute to their heterogeneity. We here review major EMT-driven properties that may help hybrid E/M CTCs to survive in the bloodstream and accomplish early phases of metastatic colonization. We then discuss how interrogating EMT in CTCs as a companion biomarker could help refine cancer patient management, supporting further the relevance of CTCs in personalized medicine.

Disciplines :

Oncology

Author, co-author :

Genna, Anthony ^✱; Université de Liège - ULiège > Cancer-Tumours and development biology

Vanwynsberghe, Aline ^✱; Université de Liège - ULiège > Cancer-Tumours and development biology

Villard, Amélie ^✱; Université de Liège - ULiège > Cancer-Tumours and development biology

POTTIER, Charles ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses - médecine interne

Ancel, Julien

Polette, Myriam

Gilles, Christine ; Université de Liège - ULiège > Cancer-Tumours and development biology

^✱ These authors have contributed equally to this work.

Language :

English

Title :

EMT-Associated Heterogeneity in Circulating Tumor Cells : Sticky Friends on the Road to Metastasis

Publication date :

2020

Journal title :

Cancers

eISSN :

2072-6694

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Volume :

Issue :

Pages :

1632

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 June 2020

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