Article (Scientific journals)
Evolving concepts on the management of dyslipidaemia.
Descamps, Olivier S.; Verhaegen, Ann; Demeure, Fabien et al.
2020In Acta Clinica Belgica, 75 (1), p. 80-90
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Keywords :
Cardiovascular prevention; atherosclerosis; cholesterol; coronary heart disease; genetic
Abstract :
[en] It has been well established that low-density lipoproteins (LDL) and other apolipoprotein B-containing lipoproteins are causally related to atherosclerotic cardiovascular disease (ASCVD) and that lowering these lipoproteins reduces the risk of ASCVD. By lowering LDL particles as much as possible, ASCVD can be prevented. There seems to be no LDL-cholesterol (LDL-C) threshold below which no further ASCVD prevention can be achieved. Furthermore, a low (an even very low) LDL-C appears to be safe. The new ESC/EAS guidelines based on these concepts are a step towards a benefit-based strategy by focusing on the clinical benefit that can be achieved by treating the cause of ASCVD. It is recommended to lower LDL-C as much as possible to prevent ASCVD, especially in high and very high-risk patients. With these new recommendations come recognition of the importance of combination therapies in high and very high-risk patients, first with statins and ezetimibe, and if needed with a PCSK9 inhibitor. The present paper is a review of some new concepts arising during the past 10 years in the field of lipidology and the description of what is new in the 2019 EAS/ESC guidelines.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Descamps, Olivier S.
Verhaegen, Ann
Demeure, Fabien
Langlois, Michel
Rietzschel, Ernst
Mertens, Anne
De Sutter, Johan
Wallemacq, Caroline
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
De Backer, Guy
Language :
Title :
Evolving concepts on the management of dyslipidaemia.
Publication date :
Journal title :
Acta Clinica Belgica
Publisher :
Taylor and Francis, Abingdon, United Kingdom
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
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since 08 June 2020


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