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An Investigation into the Clinical Utility of Transfer Functions between the Aortic and Femoral Pressure Waveforms
Davidson, S. M.; Pretty, C.; Balmer, J. et al.
2018In IFAC-PapersOnLine, 51 (27), p. 68-73
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Keywords :
Bio-signal analysis; Cardiovascular system; Decision support; Blood vessels; Bode diagrams; Decision support systems; Diagnosis; Physiological models; Processing; Arterial pressures; Cardio-vascular disease; Clinical environments; Clinical interventions; Decision supports; Disease progression; Pressure waveforms; Transfer functions
Abstract :
[en] Management of cardiovascular disease in intensive care would benefit from improved methods for data from clinically available, information rich arterial pressure waveforms. This paper explores the feasibility of using the transfer function between the aortic and femoral pressure waveforms as a diagnostic tool, over an experimental cohort including the progression of sepsis. Transfer functions appeared as physiologically expected, with Bode plot peaks near breathing and heartbeat frequencies. The Bode plot response to clinical interventions and disease progression also matched physiological expectations, with peaks increasing in magnitude in response to fluid infusion and attenuating in response to the progression of sepsis. While there are clear potential diagnostic benefits to the approach, further work is needed to make this information easier to rapidly interpret in a clinical environment, and to evaluate the specificity of the transfer function responses presented here to the progression of sepsis. © 2018
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Anesthesia & intensive care
Author, co-author :
Davidson, S. M.;  Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand
Pretty, C.;  Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand
Balmer, J.;  Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand
Desaive, Thomas  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Chase, J. G.;  Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand
Language :
English
Title :
An Investigation into the Clinical Utility of Transfer Functions between the Aortic and Femoral Pressure Waveforms
Publication date :
2018
Event name :
BMS 2018
Event date :
3-5 septembre 2018
Audience :
International
Journal title :
IFAC-PapersOnLine
ISSN :
2405-8971
eISSN :
2405-8963
Publisher :
Elsevier B.V.
Volume :
51
Issue :
27
Pages :
68-73
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 June 2020

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