Patent (Patents)
Combination of pejvakin and LC3B for treating hearing losses
Petit, Christine; Delmaghani, Sedigheh; Defourny, Jean et al.
2020
 

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Abstract :
[en] The balance between peroxisome biogenesis and degradation is crucial for redox cell homeostasis. The present invention is based on the findings that pejvakin is involved in the early and rapid selective autophagic degradation of peroxisome (pexophagy) in auditory hair cells subjected to sound overstimulation, by interacting with the autophagosome-associated protein MAP1LC3B. It is here demonstrated that it is possible to completely restore sound-induced pexophagy and to prevent oxidative stress in Pjvk-/- auditory hair cells by transducing in same the Pejvakin and MAP1LC3B proteins together. Thus, the present invention relates to compositions containing these two proteins, or gene vectors encoding same, as well as their therapeutic use for preventing and/or treating presbycusis, noise-induced hearing-loss or sudden sensorineural hearing loss or auditory damages induced by acoustic trauma or ototoxic substances, or hereditary hearing loss due to an altered expression level of Pejvakin or to an altered DFNB59 gene expression, in a subject in need thereof.
Disciplines :
Biochemistry, biophysics & molecular biology
Inventor :
Petit, Christine;  Institut Pasteur (Paris) > Département de Neurosciences > Unité de Génétique et Physiologie de l'Audition
Delmaghani, Sedigheh;  Institut Pasteur (Paris) > Département de Neurosciences > Unité de Génétique et Physiologie de l'Audition
Defourny, Jean  ;  Université de Liège - ULiège > Neurosciences-Cellular and tissular biology
Aghaie, Asadollah;  Institut Pasteur (Paris) > Département de Neurosciences > Unité de Génétique et Physiologie de l'Audition
Language :
English
Title (54) :
Combination of pejvakin and LC3B for treating hearing losses
Publication date (43-45) :
28 May 2020
Filing date (22) :
19 November 2018
Patent/publication number (10-11) :
WO2020104382 (A1)
Patent status (13) :
B
Priority number (30) :
EP20180306518 20181119
International classification (IPC) (51) :
A61K38/17; A61K48/00; A61P27/16
European classification (ECLA) (52) :
A61K38/1709 (EP); A61K48/005 (EP); A61P27/16 (EP); C07K14/435 (EP); A01K2217/075 (EP); A01K2227/105 (EP); A01K2267/0306 (EP); C12N2750/14143 (EP)
Applicant (71) :
Institut Pasteur
Publication organism (19) :
WIPO
Available on ORBi :
since 07 June 2020

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