Article (Scientific journals)
Correlation between non-invasive myocardial work indices and main parameters of systolic and diastolic function: results from the EACVI NORRE study.
Manganaro, Roberta; MARCHETTA, Stella; DULGHERU, Raluca Elena et al.
2020In European Heart Journal. Cardiovascular Imaging, 21, p. 533-541
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Keywords :
adult echocardiography; myocardial strain; myocardial work; speckle tracking echocardiography
Abstract :
[en] AIMS: The present study sought to evaluate the correlation between indices of non-invasive myocardial work (MW) and left ventricle (LV) size, traditional and advanced parameters of LV systolic and diastolic function by 2D echocardiography (2DE). METHODS AND RESULTS: A total of 226 (85 men, mean age: 45 +/- 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from LV pressure-strain loops using custom software. Peak LV pressure was estimated non-invasively from brachial artery cuff pressure. LV size, parameters of systolic and diastolic function and ventricular-arterial coupling were measured by echocardiography. As advanced indices of myocardial performance, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were obtained. On multivariable analysis, GWI was significantly correlated with GLS (standardized beta-coefficient = -0.23, P < 0.001), ejection fraction (EF) (standardized beta-coefficient = 0.15, P = 0.02), systolic blood pressure (SBP) (standardized beta-coefficient = 0.56, P < 0.001) and GRS (standardized beta-coefficient = 0.19, P = 0.004), while GCW was correlated with GLS (standardized beta-coefficient = -0.55, P < 0.001), SBP (standardized beta-coefficient = 0.71, P < 0.001), GRS (standardized beta-coefficient = 0.11, P = 0.02), and GCS (standardized beta-coefficient = -0.10, P = 0.01). GWE was directly correlated with EF and inversely correlated with Tei index (standardized beta-coefficient = 0.18, P = 0.009 and standardized beta-coefficient = -0.20, P = 0.004, respectively), the opposite occurred for GWW (standardized beta-coefficient =--0.14, P = 0.03 and standardized beta-coefficient = 0.17, P = 0.01, respectively). CONCLUSION: The non-invasive MW indices show a good correlation with traditional 2DE parameters of myocardial systolic function and myocardial strain.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Manganaro, Roberta
DULGHERU, Raluca Elena 
Sugimoto, Tadafumi
Tsugu, Toshimitsu
Ilardi, Federica
Cicenia, Marianna
ANCION, Arnaud  
Postolache, Adriana
Martinez, Christophe
Kacharava, George
Athanassopoulos, George D.
Barone, Daniele
Baroni, Monica
Cardim, Nuno
Hagendorff, Andreas
Hristova, Krasimira
Lopez, Teresa
de la Morena, Gonzalo
Popescu, Bogdan A.
Penicka, Martin
Ozyigit, Tolga
Rodrigo Carbonero, Jose David
van de Veire, Nico
Von Bardeleben, Ralph Stephan
Vinereanu, Dragos
Zamorano, Jose Luis
Rosca, Monica
Calin, Andreea
Moonen, Marie
Magne, Julien
Cosyns, Bernard
Galli, Elena
Donal, Erwan
Carerj, Scipione
Zito, Concetta
Santoro, Ciro
Galderisi, Maurizio
Badano, Luigi P.
Lang, Roberto M.
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
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Language :
Title :
Correlation between non-invasive myocardial work indices and main parameters of systolic and diastolic function: results from the EACVI NORRE study.
Publication date :
May 2020
Journal title :
European Heart Journal. Cardiovascular Imaging
Publisher :
Oxford University Press, United Kingdom
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Published on behalf of the European Society of Cardiology. All rights reserved. (c) The Author(s) 2019. For permissions, please email:
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since 07 June 2020


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