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07 June 2020
Article (Scientific journals)
A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies.
Dourcy, Mickael  ; Maquet, Céline  ; Dams, Lorène  et al.
2020 • In Mucosal Immunology
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Keywords :
Immunopathologies; respiratory viral infections; lung immunity
Abstract :
[en] Human respiratory syncytial virus (RSV) is a pneumovirus that causes severe infections in infants worldwide. Despite intensive research, safe and effective vaccines against RSV have remained elusive. The main reason is that RSV infection of children previously immunized with formalin-inactivated-RSV vaccines has been associated with exacerbated pathology, a phenomenon called RSV vaccine-enhanced respiratory disease. In parallel, despite the high RSV prevalence, only a minor proportion of children develop severe diseases. Interestingly, variation in the immune responses against RSV or following RSV vaccination could be linked with differences of exposure to microbes during childhood. Gammaherpesviruses (γHVs), such as the Epstein–Barr virus, are persistent viruses that deeply influence the immune system of their host and could therefore affect the development of pneumovirus-induced immunopathologies for the long term. Here, we showed that a previous ɣHV infection protects against both pneumovirus vaccine-enhanced disease and pneumovirus primary infection and that CD8 T cells are essential for this protection. These observations shed a new light on the understanding of pneumovirus-induced diseases and open new perspectives for the development of vaccine strategies.
Disciplines :
Immunology & infectious disease
Author, co-author :
Dourcy, Mickael ;  Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Anatomie des animaux domestiques
Maquet, Céline  ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
Dams, Lorène ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Département des maladies infectieuses et parasitaires (DMI)
Gilliaux, Gautier ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Santé et pathologies de la faune sauvage
Javaux, Justine ;  Université de Liège - ULiège > Immunologie vétérinaire
Desmecht, Daniel ;  Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Pathologie spéciale et autopsies
Mack, Matthias;  Regensburg University Medical Center, Germany
Dewals, Benjamin G  ;  Université de Liège - ULiège > Immunologie vétérinaire
Machiels, Bénédicte  ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
Gillet, Laurent   ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
 These authors have contributed equally to this work.
Language :
English
Title :
A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies.
Publication date :
18 May 2020
Journal title :
Mucosal Immunology
ISSN :
1933-0219
eISSN :
1935-3456
Publisher :
Nature Publishing Group, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi

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