Reference : A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced ...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/248105
A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies.
English
Dourcy, Mickael mailto [Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Anatomie des animaux domestiques >]
Maquet, Céline mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire >]
Dams, Lorène mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Département des maladies infectieuses et parasitaires (DMI) >]
Gilliaux, Gautier mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Santé et pathologies de la faune sauvage >]
Javaux, Justine mailto [Université de Liège - ULiège > > Immunologie vétérinaire >]
Desmecht, Daniel mailto [Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Pathologie spéciale et autopsies >]
Mack, Matthias mailto [Regensburg University Medical Center, Germany > > > >]
Dewals, Benjamin G mailto [Université de Liège - ULiège > > Immunologie vétérinaire >]
Machiels, Bénédicte* mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire >]
Gillet, Laurent* mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire >]
* These authors have contributed equally to this work.
18-May-2020
Mucosal Immunology
Nature Publishing Group
Yes (verified by ORBi)
International
1933-0219
1935-3456
United Kingdom
[en] Immunopathologies ; respiratory viral infections ; lung immunity
[en] Human respiratory syncytial virus (RSV) is a pneumovirus that causes severe infections in infants worldwide. Despite intensive research, safe and effective vaccines against RSV have remained elusive. The main reason is that RSV infection of children previously immunized with formalin-inactivated-RSV vaccines has been associated with exacerbated pathology, a phenomenon called RSV vaccine-enhanced respiratory disease. In parallel, despite the high RSV prevalence, only a minor proportion of children develop severe diseases. Interestingly, variation in the immune responses against RSV or following RSV vaccination could be linked with differences of exposure to microbes during childhood. Gammaherpesviruses (γHVs), such as the Epstein–Barr virus, are persistent viruses that deeply influence the immune system of their host and could therefore affect the development of pneumovirus-induced immunopathologies for the long term. Here, we showed that a previous ɣHV infection protects against both pneumovirus vaccine-enhanced disease and pneumovirus primary infection and that CD8 T cells are essential for this protection. These observations shed a new light on the understanding of pneumovirus-induced diseases and open new perspectives for the development of vaccine strategies.
Researchers
http://hdl.handle.net/2268/248105

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