Article (Scientific journals)
Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential.
Di Gregorio, Marina; LOMBARD, Arnaud; Lumapat, Paul Noel et al.
2019In Cells
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Keywords :
Gliomas; Protein synthesis; translation
Abstract :
[en] Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological stress. This phenomenon has been described in several cancers including in gliomas. Abnormal regulation of translation has encouraged the development of new therapeutics targeting the protein synthesis pathway. This approach could be meaningful for glioma given the fact that the median survival following diagnosis of the highest grade of glioma remains short despite current therapy. The identification of new targets for the development of novel therapeutics is therefore needed in order to improve this devastating overall survival rate. This review discusses current literature on translation in gliomas with a focus on the initiation step covering both the cap-dependent and cap-independent modes of initiation. The different translation initiation protagonists will be described in normal conditions and then in gliomas. In addition, their gene expression in gliomas will systematically be examined using two freely available datasets. Finally, we will discuss different pathways regulating translation initiation and current drugs targeting the translational machinery and their potential for the treatment of gliomas.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Oncology
Author, co-author :
Di Gregorio, Marina  ;  Université de Liège - ULiège > Cancer-Experimental Pathology
LOMBARD, Arnaud  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service de neurochirurgie
Lumapat, Paul Noel ;  Université de Liège - ULiège > Neurosciences-Nervous system disorders and therapy
Scholtes, Félix  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
ROGISTER, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie
Coppieters't Wallant, Natacha ;  Université de Liège - ULiège > Neurosciences-Nervous system disorders and therapy
Language :
English
Title :
Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential.
Publication date :
29 November 2019
Journal title :
Cells
eISSN :
2073-4409
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Basel, Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 June 2020

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