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Multivariate functional network connectivity for disorders of consciousness
Rudas, Jorge; Martínez, Darwin; Demertzi, Athina et al.
2017In Lecture Notes in Computer Science, 10125 LNCS, p. 434-442


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Keywords :
Community; Disorders of consciousness; Hyperedge; Multivariate functional network connectivity; Resting state networks; Brain; Complex networks; Functional network; Resting state; Pattern recognition
Abstract :
[en] Recent evidence suggests that healthy brain is organized on large-scale spatially distant brain regions, which are temporally synchronized. These regions are known as resting state networks (RSNs). The level of interaction among these functional entities has been studied in the so called functional network connectivity (FNC). FNC aims to quantify the level of interaction between pairs of RSNs, which commonly emerge at similar spatial scale. Nevertheless, the human brain is a complex functional structure which is partitioned into functional regions that emerge at multiple spatial scales. In this work, we propose a novel multivariate FNC strategy to study interactions among communities of RSNs, these communities may emerge at different spatial scales. For this, first a community or hyperedge detection strategy was used to conform groups of RSNs with a similar behavior. Following, a distance correlation measurement was employed to quantify the level of interaction between these communities. The proposed strategy was evaluated in the characterization of patients with disorders of consciousness, a highly challenging problem in the clinical setting. The results suggest that the proposed strategy may improve the capacity of characterization of these brain altered conditions.
Disciplines :
Author, co-author :
Rudas, Jorge;  Department of Biotechnology, Universidad Nacional de Colombia, Bogotá, Colombia
Martínez, Darwin;  Department of Computer Science, Universidad Nacional de Colombia, Bogotá, Colombia, Department of Computer Science, Universidad Central, Bogotá, Colombia
Demertzi, Athina  ;  Université de Liège - ULiège > Consciousness-Physiology of Cognition
Di Perri, Carol ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Heine, Lizette ;  Coma Science Group, GIGA Research Center, University of Liège, Liège, Belgium
TSHIBANDA, Luaba ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > Service médical de radiodiagnostic
Soddu, Andrea;  Department of Physics and Astronomy, Western University, London, Canada
Laureys, Steven  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Gómez, Francisco;  Department of Mathematics, Universidad Nacional de Colombia, Bogotá, Colombia
Language :
Title :
Multivariate functional network connectivity for disorders of consciousness
Publication date :
Event name :
21st Iberoamerican Congress on Pattern Recognition, CIARP 2016
Event date :
8 November 2016 through 11 November 2016
Audience :
Journal title :
Lecture Notes in Computer Science
Publisher :
Springer Verlag
Volume :
10125 LNCS
Pages :
Name of the research project :
French Speaking Community Concerted Research Action
Interuniversity Attraction Poles (IAP)
Funders :
JSMF - James S McDonnell Foundation [US-MO] [US-MO]
ASE - Agence Spatiale Européenne [FR]
MSF - Mind Science Foundation [US-TX] [US-TX]
French-Speaking Community of Belgium [BE]
BELSPO - Belgian Science Policy Office [BE]
UET - Université Européenne du Travail [BE]
FERB - Fondazione Europea Ricerca Biomedica [IT]
CHU Liège - Central University Hospital of Liege [BE]
Funding text :
Agreement Gobernaci´on del Magdalena - COLCIENCIAS (Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnologa).
Commentary :
189129 9783319522760
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