Article (Scientific journals)
Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
Schmitt, Christina; Lechanteur, Anna; Cossais, François et al.
2020In International Journal of Nanomedicine, 15, p. 3649—3667
Peer reviewed
 

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Keywords :
glial scar; nanoparticles; brain implants; neuroinflammation
Abstract :
[en] Introduction: The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries. Methods: We developed a protocol for the efficient encapsulation of curcumin as a model for anti-inflammatory drugs yielding long-term stable, non-toxic liposomes with favorable physicochemical properties. Subsequently, we evaluate the effects of liposomal curcumin in experimental models for neuroinflammation and reactive astrogliosis. Results: We could show that liposomal curcumin can efficiently reduce the reactivity of human microglia and astrocytes and preserve tissue integrity of murine organotypic cortex slices. Discussion and Perspective: In perspective, we want to administer this curcumin formulation in brain implant coatings to prevent neuroinflammation and glial scar formation as foreign body responses of the brain towards implanted materials.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Schmitt, Christina
Lechanteur, Anna  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Cossais, François
Bellefroid, Coralie ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Arnold, Philipp
Lucius, Ralph
Held-Feindt, Janka
Piel, Géraldine ;  Université de Liège - ULiège > Département de pharmacie > Développement de nanomédicaments
Hattermann, Kirsten
Language :
English
Title :
Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
Publication date :
2020
Journal title :
International Journal of Nanomedicine
ISSN :
1176-9114
eISSN :
1178-2013
Publisher :
Dove Medical Press Ltd, New Zealand
Volume :
15
Pages :
3649—3667
Peer reviewed :
Peer reviewed
Available on ORBi :
since 27 May 2020

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