Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices

Schmitt, Christina; Lechanteur, Anna; Cossais, François; Bellefroid, Coralie; Arnold, Philipp; Lucius, Ralph; Held-Feindt, Janka; Piel, Géraldine; Hattermann, Kirsten

doi:10.2147/IJN.S245300

Article (Scientific journals)

Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices

Schmitt, Christina; Lechanteur, Anna; Cossais, François et al.

2020 • In International Journal of Nanomedicine, 15, p. 3649—3667

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/247771

DOI
10.2147/IJN.S245300

PubMed
32547020

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Keywords :

glial scar; nanoparticles; brain implants; neuroinflammation

Abstract :

[en] Introduction: The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries. Methods: We developed a protocol for the efficient encapsulation of curcumin as a model for anti-inflammatory drugs yielding long-term stable, non-toxic liposomes with favorable physicochemical properties. Subsequently, we evaluate the effects of liposomal curcumin in experimental models for neuroinflammation and reactive astrogliosis. Results: We could show that liposomal curcumin can efficiently reduce the reactivity of human microglia and astrocytes and preserve tissue integrity of murine organotypic cortex slices. Discussion and Perspective: In perspective, we want to administer this curcumin formulation in brain implant coatings to prevent neuroinflammation and glial scar formation as foreign body responses of the brain towards implanted materials.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Schmitt, Christina

Lechanteur, Anna ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Cossais, François

Bellefroid, Coralie ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Arnold, Philipp

Lucius, Ralph

Held-Feindt, Janka

Piel, Géraldine ; Université de Liège - ULiège > Département de pharmacie > Développement de nanomédicaments

Hattermann, Kirsten

Language :

English

Title :

Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices

Publication date :

2020

Journal title :

International Journal of Nanomedicine

ISSN :

1176-9114

eISSN :

1178-2013

Publisher :

Dove Medical Press Ltd, New Zealand

Volume :

Pages :

3649—3667

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 May 2020

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