[en] Introduction: The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries.
Methods: We developed a protocol for the efficient encapsulation of curcumin as a model for anti-inflammatory drugs yielding long-term stable, non-toxic liposomes with favorable physicochemical properties. Subsequently, we evaluate the effects of liposomal curcumin in experimental models for neuroinflammation and reactive astrogliosis.
Results: We could show that liposomal curcumin can efficiently reduce the reactivity of human microglia and astrocytes and preserve tissue integrity of murine organotypic cortex slices.
Discussion and Perspective: In perspective, we want to administer this curcumin formulation in brain implant coatings to prevent neuroinflammation and glial scar formation as foreign body responses of the brain towards implanted materials.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Schmitt, Christina
Lechanteur, Anna ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Cossais, François
Bellefroid, Coralie ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Arnold, Philipp
Lucius, Ralph
Held-Feindt, Janka
Piel, Géraldine ; Université de Liège - ULiège > Département de pharmacie > Développement de nanomédicaments
Hattermann, Kirsten
Language :
English
Title :
Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
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