Bioactive compounds; Enyne metathesis; Ring-closing metathesis; Ruthenium catalysts; Tandem reactions
Abstract :
[en] This account surveys the current progress on the application of intra- and intermolecular enyne metathesis as main key steps in the synthesis of challenging structural motifs and stereochemistries found in bioactive compounds. Special emphasis is placed on ruthenium catalysts as promoters of enyne metathesis to build the desired 1,3-dienic units. The advantageous association of this approach with name reactions like Grignard, Wittig, Diels–Alder, Suzuki–Miyaura, Heck cross-coupling, etc. is illustrated. Examples unveil the generality of such tandem reactions in providing not only the intricate structures of known, in vivo effective substances but also for designing chemically modified analogs as valid alternatives for further therapeutic agents.
Disciplines :
Chemistry
Author, co-author :
Dragutan, Valerian; Institute of Organic Chemistry of the Romanian Academy, Bucharest, 060023, Romania
Dragutan, Ileana; Institute of Organic Chemistry of the Romanian Academy, Bucharest, 060023, Romania
Demonceau, Albert ; Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
Delaude, Lionel ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organométallique et catalyse homogène
Language :
English
Title :
Combining enyne metathesis with long-established organic transformations: A powerful strategy for the sustainable synthesis of bioactive molecules
Publication date :
2020
Journal title :
Beilstein Journal of Organic Chemistry
eISSN :
1860-5397
Publisher :
Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
Volume :
16
Pages :
738-755
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
WBI - Wallonie-Bruxelles International [BE] Academia Română [RO]
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