Article (Scientific journals)
La gastrite chronique auto-immune : une prise en charge multidisciplinaire.
VALDES SOCIN, Hernan Gonzalo; LECLERCQ, Philippe; POLUS, Marc et al.
2019In Revue Médicale de Liège, 74 (11), p. 598-605
 

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Keywords :
Autoimmune Diseases/complications; Gastrins; Gastritis/immunology; Gastritis, Atrophic/immunology; Helicobacter Infections/complications; Helicobacter pylori; Humans; Diagnosis; Gastric neuroendocrine tumor; Thyrogastric autoimmune syndrome; Treatment; Chronic autoimmune gastritis
Abstract :
[en] Chronic autoimmune gastritis (CAG) is a continuum of histological changes in gastric mucosa including: atrophy, intestinal metaplasia, dysplasia and finally, the occurrence of a neoplasm (gastric Neuroendocrine Tumors -NETs- and adenocarcinoma). The association with Hashimoto and Graves-Basedow disease is known as the thyrogastric autoimmune syndrome. While Helicobacter pylori (Hp) infection may be associated with CAG, the role of the gastric microbiota is ill-defined. The gastric hypochlorhydria determines a malabsorption of different micronutrients (iron, magnesium, calcium, vitamin B12) as well as drugs (thyroxine, etc.). Pernicious anemia is favoured by the deficit of parietal intrinsic factor that contributes to B12 malabsorption. Serology for Hp, serum pepsinogen I/II, increased gastrin levels, the presence of parietal cell antibodies and intrinsic factor antibodies may reveal CAG. High definition endoscopy associated with virtual chromoendoscopy seems promising for CAG diagnosis and follow-up. NETs type 1 treatment includes: endoscopic and surgical resection, somatostatin analogues and the recent availability of netazepide, a gastrin antagonist. We review herein advances in the treatment and diagnosis of CAG and associated autoimmune disorders, which may involve, in a multidisciplinary way, all practitioners.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
VALDES SOCIN, Hernan Gonzalo  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
LECLERCQ, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de gastroentérologie, hépatologie, onco. digestive
POLUS, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de gastroentérologie, hépatologie, onco. digestive
Rohmer, Vincent ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Beckers, Albert ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Louis, Edouard  ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
Language :
French
Title :
La gastrite chronique auto-immune : une prise en charge multidisciplinaire.
Alternative titles :
[en] Chronic autoimmune gastritis : a multidisciplinary management
Publication date :
2019
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
74
Issue :
11
Pages :
598-605
Available on ORBi :
since 19 May 2020

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