[en] Sylvatic rabies can be efficiently controlled by vaccination of foxes with a vaccinia-rabies recombinant virus. However, the risk of recombination between the engineered vaccine virus and other orthopoxviruses endemic in wildlife, such as cowpox virus, still needs to be investigated. In this study, foxes inoculated orally and intradermally with cowpox virus were found to be not very susceptible to cowpox virus, which was isolated from only the oropharynx and tonsils, at low titre and for only five days after inoculation. Thus the risk of recombination between these viruses in foxes is very low.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Boulanger, Denise; Université de Liège - ULiège > Faculty of Veterinary Medicine > Immunology-Vaccinology
Brochier, Bernard; Université de Liège - ULiège > Faculty of Veterinary Medicine > Immunology-Vaccinology
Crouch, A.; University of Liverpool > Veterinary Clinical Science
Bennett, M.; University of Liverpool > Veterinary Pathology
Gaskell, R. M.; University of Liverpool > Veterinary Clinical Science
Baxby, D.; University of Liverpool > Medical Microbiology
Pastoret, Paul-Pierre ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Immunology-Vaccinology
Language :
English
Title :
Comparison of the Susceptibility of the Red Fox (Vulpes Vulpes) to a Vaccinia-Rabies Recombinant Virus and to Cowpox Virus
Kieny, Lathé, Drillien, Spehner, Skory, Schmitt (1984) Expression of rabies virus glycoprotein from a recombinant vaccinia virus. Nature 312:163-166.
Pastoret, Brochier, Blancou, Artois, Aubert, Kieny (1992) Development and deliberate release of a vaccinia-rabies recombinant virus for the oral vaccination of foxes against rabies. Recombinant Poxviruses , M.M. Binns, G.L. Smith, CRC Press, Boca Raton, FL, USA; 163-206.
Blancou, Kieny, Lathé, Lecocq, Pastoret, Soulebot, Desmettre (1986) Oral vaccination of the fox against rabies using a live recombinant vaccinia virus. Nature 322:373-375.
Brochier, Languet, Blancou, Kieny, Lecocq, Costy (1988) Use of a recombinant vaccinia-rabies virus for oral vaccination of fox cubs (Vulpes vulpes, L.) against rabies. Vet. Microbiol. 18:103-108.
Brochier, Blancou, Thomas, Languet, Artois, Kieny (1989) Use of recombinant vaccinia-rabies glycoprotein virus for oral vaccination of wildlife against rabies: Innocuity to several non-target bait consuming species. J. Wildl. Dis. 25:540-547.
Winkler, Shaddock, Williams (1976) Oral rabies vaccine: evaluation of its infectivity in three species of rodents. Am. J. Epidemiol. 104:294-298.
Wandeler, Bauder, Prochaska, Steck (1982) Small mammal studies in a SAD baiting area. Comp. Immunol. Microbiol. Infect. Dis. 5:173-176.
Leblois, Flamand (1988) Studies on pathogenicity in mice of rabies virus strains used for oral vaccination of foxes in Europe. Vaccination to control rabies in foxes (La vaccination antirabique du renard) , P.-P. Pastoret, B. Brochier, I. Thomas, J. Blancou, Commission of the European Communities, EUR 11439 EN-FR; 101-104.
Bingham, Foggin, Gerber, Hil, Kappeler, King (1992) The pathogenicity of SAD rabies vaccine in chacma baboons (Papio ursinus) given by the oral route. Vet. Rec. 131:55-56.
Artois, Guittre, Thomas, Leblois, Brochier, Barrat (1992) Potential pathogenicity for rodents of vaccines intended for oral vaccination against rabies: a comparison. Vaccine 10:524-528.
Brochier, Kieny, Costy, Coppens, Bauduin, Lecocq (1991) Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine. Nature 354:520.
Brochier, Coppens, Costy, Peharpre, Marchal, Hallet (1993) Programme d'éradication de la rage en Belgique par la vaccination du renard: bilan 1992. Ann. Méd. Vét. 137:285-291.
Baxby (1977) Is cowpox misnamed-a review of 10 human cases. BMJ 1:1379-1381.
Marennikova, Ladnyj, Ogorodnikova, Shelukhina, Maltseva (1978) Identification and study of a poxvirus isolated from wild rodents in Turkmenia. Arch. Virol. 56:7-14.
Baxby, Gaskell, Gaskell, Bennett (1986) Ecology of orthopoxviruses and use of recombinant vaccinia vaccines. Lancet 2:850-851.
Egberink, Willemse, Horzinek (1986) Isolation and identification of a poxvirus from a domestic cat and a human contact case. J. Vet. Med. B 33:237-240.
Bennett, Gaskell, Baxby, Gaskell, Kelly, Naidoo (1990) Feline cowpox virus infection. Journal of Small Animal Practice 31:167-173.
Maenhout, Declercq, De Keuster, Hoorens (1991) Drie gevallen van koepokkeninfektie bij de kat in Belgie. Vlaams Diergeneeskd Tijdschr. 60:64-67.
Thomas, Brochier, Languet, Blancou, Peharpre, Kieny (1990) Primary multiplication site of the vaccinia-rabies glycoprotein recombinant virus administered to foxes by the oral route. J. Gen. Virol. 71:37-42.
Gaskell, Gaskell, Evans, Dennis, Bennett, Udall (1983) Natural and experimental poxvirus infection in the domestic cat. Vet. Rec. 112:164-170.
Bennett, Baxby, Gaskell, Gaskell, Kelly (1985) The laboratory diagnosis of Orthopoxvirus infection in the domestic cat. Journal of Small Animal Practice 26:653-661.
Smith, Jager, Baer (1973) A rapid time culture test for determining rabies neutralizing antibodies. Laboratory Techniques in Rabies , M.M. Kaplan, H. Koprowski, 3rd ed., World Health Organization, Geneva; 354-357.
Bennett, Gaskell, Gaskell, Baxby, Kelly (1989) Studies on poxvirus infection in cats. Arch. Virol. 104:19-33.
Fenner, Comben (1958) Genetic studies with mammalian poxviruses. I. Demonstration of recombination between two strains of vaccinia virus. Virology 5:530-548.
Ball (1987) High-frequency homologous recombination in vaccinia virus DNA. J. Virol. 61:1788-1795.
Chernos, Antonova, Senkevich (1985) Recombinants between vaccinia and ectromelia viruses bearing the specific pathogenicity markers of both parents. J. Gen. Virol. 66:621-626.
Chernos, Senkevich, Chelyapov, Antonova, Vovk, Mitina (1987) Biologic properties and genome structure of the recombinants between ectromelia and rabbitpox viruses. Acta Virol. 31:193-202.
Gershon, Kitching, Hammond, Black (1989) Poxvirus genetic recombination during natural virus transmission. J. Gen. Virol. 70:485-489.
Strayer, Cabirac, Sell, Leibowitz (1983) Malignant rabbit fibroma virus: Observations on the culture and histopathologic characteristics of a new virus-induced rabbit tumor. J. Natl Cancer Inst. 71:91-104.
