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Coll2-1 and Coll2-1NO2 as exemplars of collagen extracellular matrix turnover–biomarkers to facilitate the treatment of osteoarthritis?

Mobasheri, Ali; Lambert, Cécile; Henrotin, Yves

2019 • In Expert Review of Molecular Diagnostics, 19 (9), p. 803-812

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/247195

DOI
10.1080/14737159.2019.1646641

PubMed
31327279

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Keywords :

Coll2-1; Coll2-1NO2; Osteoarthritis (OA)

Abstract :

[en] Introduction: Osteoarthritis (OA) is the most common form of arthritis. However, there are no structure or disease-modifying OA drugs (DMOADs). Introducing personalized healthcare to patients and health-care practitioners is a high priority for the management of arthritic and musculoskeletal diseases. However, there are no biomarker tools that can be used for patient stratification, disease management, and drug development. Biomarkers are capable of diagnosing and prognosing some arthritic and musculoskeletal diseases. Cartilage-based biomarkers have the potential to be used in this context to guide the precision treatment of OA. Areas covered: The aim of this review is to focus on the pre-clinical and clinical utility of the Coll2-1 and Coll2-1NO2 biomarkers as unique cartilage-based biomarkers that can guide the development of new treatments for OA. This expert report will begin with a background to collagens and their important biomechanical roles in the musculoskeletal system, but particularly cartilage, before exploring the data and scientific evidence to support the utility of Coll2-1 and Coll2-1NO2 as unique biomarkers. Expert opinion: This review summarises the authors’ expert view on the pre-clinical and clinical utility of the Coll2-1 and Coll2-1NO2 biomarkers and their potential for use as drug development tools. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Disciplines :

Rheumatology

Author, co-author :

Mobasheri, Ali; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania, Centre for Sport, Exercise and Osteoarthritis Versus Arthritis, Queen’s Medical Centre, Nottingham, United Kingdom, European Commission, The D-BOARD FP7 Consortium, United Kingdom, The APPROACH IMI Consortium, United Kingdom, Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland

Lambert, Cécile ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Language :

English

Title :

Coll2-1 and Coll2-1NO2 as exemplars of collagen extracellular matrix turnover–biomarkers to facilitate the treatment of osteoarthritis?

Publication date :

2019

Journal title :

Expert Review of Molecular Diagnostics

ISSN :

1473-7159

eISSN :

1744-8352

Publisher :

Taylor and Francis Ltd

Volume :

19

Issue :

9

Pages :

803-812

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 06 May 2020

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