Serum biomarkers in people with chronic low back pain and Modic 1 changes: a case-control study

[en] We aimed to compare serum biomarkers of inflammation, redox status and cartilage degradation between chronic low back pain (cLBP) patients with and without Modic 1 changes. We used a convenience sample of patients recruited from a single center, case-control study, conducted in a tertiary care center. From December, 2014 to May, 2016, 2,292 patients were consecutively screened, 34 met inclusion criteria and were prospectively enrolled in the present study. Cases (n = 13) were defined as patients with Modic 1 changes detected on MRI and controls (n = 21) as cLBP patients without (Modic 0). To assess serum biomarkers of inflammation, redox status and cartilage degradation, fasting serum samples were collected in a standardized manner and analyzed by immunoassays and spectrophotometry. Mean (95% CI) age was 44.1 (40.0–48.1) years and mean LBP duration was 72.5 (53.0–91.9) months. Serum biomarkers of inflammation (IL-1β, IL-6, IL-8 and TNF-α), redox status (total thiols, advanced oxidation protein products and carbonyl groups) and cartilage degradation (Coll2-1 and Coll2-1NO2) did not differ between cLBP patients with and without Modic 1 changes. In summary, we did not find any differences in serum biomarkers between cLBP patients with and without Modic 1 changes. Interpretation is limited by convenience sampling and small sample size. © 2019, The Author(s).

Disciplines :

Rheumatology

Author, co-author :

Boisson, M.; AP-HP, Service de Rééducation et de Réadaptation de l’Appareil Locomoteur et des Pathologies du Rachis, Hôpitaux Universitaires Paris Centre - Groupe Hospitalier Cochin, Paris, 75014, France

Borderie, D.; Université de Paris, UFR Pharmacie, Sorbonne Paris Cité, Paris, 75006, France, AP-HP, Service de Diagnostic Biologique Automatisé, Hôpitaux Universitaires Paris Centre - Groupe Hospitalier Cochin, Paris, 75014, France, INSERM UMR 1124, Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire, UFR Sciences Fondamentales et Biomédicales, Paris, 75006, France

Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Teboul-Coré, S.; AP-HP, Service de Rééducation et de Réadaptation de l’Appareil Locomoteur et des Pathologies du Rachis, Hôpitaux Universitaires Paris Centre - Groupe Hospitalier Cochin, Paris, 75014, France

Lefèvre-Colau, M.-M.; AP-HP, Service de Rééducation et de Réadaptation de l’Appareil Locomoteur et des Pathologies du Rachis, Hôpitaux Universitaires Paris Centre - Groupe Hospitalier Cochin, Paris, 75014, France, Université de Paris, UFR Médecine, Sorbonne Paris Cité, Paris, 75006, France, INSERM UMR 1153, Centre de Recherche Épidémiologie et Statistique Paris Sorbonne Cité (CRESS), ECaMO Team, Paris, 75006, France, Institut Fédératif de Recherche sur le Handicap, Paris, 75013, France

Rannou, F.; AP-HP, Service de Rééducation et de Réadaptation de l’Appareil Locomoteur et des Pathologies du Rachis, Hôpitaux Universitaires Paris Centre - Groupe Hospitalier Cochin, Paris, 75014, France, INSERM UMR 1124, Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire, UFR Sciences Fondamentales et Biomédicales, Paris, 75006, France, Université de Paris, UFR Médecine, Sorbonne Paris Cité, Paris, 75006, France

Nguyen, C.; AP-HP, Service de Rééducation et de Réadaptation de l’Appareil Locomoteur et des Pathologies du Rachis, Hôpitaux Universitaires Paris Centre - Groupe Hospitalier Cochin, Paris, 75014, France, INSERM UMR 1124, Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire, UFR Sciences Fondamentales et Biomédicales, Paris, 75006, France, Université de Paris, UFR Médecine, Sorbonne Paris Cité, Paris, 75006, France

Language :

English

Title :

Serum biomarkers in people with chronic low back pain and Modic 1 changes: a case-control study

Publication date :

2019

Journal title :

Scientific Reports

eISSN :

2045-2322

Publisher :

Nature Publishing Group

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

AP-HP - Assistance publique-Hôpitaux de Paris

Available on ORBi :

since 22 April 2020

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