apathy; therapy; motivation; daily functioning; quality of life; rehabilitation; recovery
Abstract :
[en] Objective: People diagnosed with schizophrenia experience difficulties in their daily life, which is best explained by motivational negative symptoms. This study explores the feasibility, acceptability and efficacy of Switch, a new multifactorial intervention that targets motivational deficits. Method: Eight participants with schizophrenia or schizoaffective disorder followed around 30 individual sessions of Switch over 12 months. Participants and their informants were interviewed at baseline (T0), at 6 months (T1), at the end of the intervention (T2) and at 6 months follow-up (T3). Results: T0-T1 paired sample t-tests showed large improvements on motivational deficits, general negative symptoms, and apathy and functional outcomes (both as rated by informants). At T2 and T3, moderate to large improvements were maintained. Switch was well accepted by participants. Conclusions: This preliminary investigation provides evidence that Switch may be an acceptable and effective intervention specifically designed to target motivational deficits and improve daily functioning.
Auquier, P., Simeoni, M. C., Sapin, C., Reine, G., Aghababian, V., Cramer, J., & Lançon, C. (2003). Development and validation of a patient-based health-related quality of life questionnaire in schizophrenia: The S-QoL. Schizophrenia Research, 63(1–2), 137–149. https://doi.org/10.1016/S0920-9964(02)00355-9
Carpenter, W. T., & Buchanan, R. W. (2017). Negative symptom therapeutics. Schizophrenia Bulletin, 43, 681–682. https://doi.org/10.1093/schbul/sbx054
Chang, W. C., Wong, C. S. M., Or, P. C. F., Chu, A. O. K., Hui, C. L. M., Chan, S. K. W., & Chen, E. Y. H. (2019). Inter-relationships among psychopathology, premorbid adjustment, cognition and psychosocial functioning in first-episode psychosis: A network analysis approach. Psychological Medicine, 1–9. https://doi.org/10.1017/S0033291719002113
Chen, T., Liu, L., Cui, J., Li, Y., Qin, X., Tao, S., … Chan, R. C. K. (2019). Implementation intention training for prospective memory in schizophrenia: A 3-month follow-up study. Schizophrenia Research, 206, 378–385. https://doi.org/10.1016/j.schres.2018.10.015
Cohen J. (1992). A power primer. Psychological Bulletin, 112(1), 155–159. https://doi.org/10.1037/0033-2909.112.1.155
Dujardin, K., Sockeel, P., Delliaux, M., Destée, A., & Defebvre, L. (2008). The Lille Apathy Rating Scale: Validation of a caregiver-based version. Movement Disorders, 23(6), 845–849. https://doi.org/10.1002/mds.21968
Farquharson, L., & MacLeod, A. K. (2014). A brief goal-setting and planning intervention to improve well-being for people with psychiatric disorders. Psychotherapy and Psychosomatics, 83(2), 122–124. https://doi.org/10.1159/000356332
Favrod, J., Nguyen, A., Chaix, J., Pellet, J., Frobert, L., Fankhauser, C., … Bonsack, C. (2019). Improving pleasure and motivation in schizophrenia: A randomized controlled clinical trial. Psychotherapy and Psychosomatics, 88(2), 1–12. https://doi.org/10.1159/000496479
Foussias, G., Agid, O., Fervaha, G., & Remington, G. (2014). Negative symptoms of schizophrenia: Clinical features, relevance to real world functioning and specificity versus other CNS disorders. European Neuropsychopharmacology, 24(5), 693–709. https://doi.org/10.1016/j.euroneuro.2013.10.017
Fusar-Poli, P., Papanastasiou, E., Stahl, D., Rocchetti, M., Carpenter, W., Shergill, S., & McGuire, P. (2015). Treatments of negative symptoms in schizophrenia: Meta-analysis of 168 randomized placebo-controlled trials. Schizophrenia Bulletin, 41, 892–899. https://doi.org/10.1093/schbul/sbu170
Kring, A. M., & Barch, D. M. (2014). The motivation and pleasure dimension of negative symptoms: Neural substrates and behavioral outputs. European Neuropsychopharmacology, 24(5), 725–736. https://doi.org/10.1016/j.euroneuro.2013.06.007
Llorca, P.-M., Lançon, C., Lancrenon, S., Bayle, F.-J., Caci, H., Rouillon, F., & Gorwood, P. (2009). The “Functional Remission of General Schizophrenia” (FROGS) scale: Development and validation of a new questionnaire. Schizophrenia Research, 113(2–3), 218–225. https://doi.org/10.1016/j.schres.2009.04.029
Lutgens, D., Gariepy, G., & Malla, A. (2017). Psychological and psychosocial interventions for negative symptoms in psychosis: Systematic review and meta-analysis. British Journal of Psychiatry, 210(5), 324–332. https://doi.org/10.1192/bjp.bp.116.197103
Medalia, A., & Brekke, J. (2010). In search of a theoretical structure for understanding motivation in schizophrenia. Schizophrenia Bulletin, 36(5), 912–918. https://doi.org/10.1093/schbul/sbq073
Mouaffak, F., Morvan, Y., Bannour, S., Chayet, M., Bourdel, M. C., Thepaut, G., … Krebs, M.-O. (2010). Validation de la version française de l’échelle abrégée d'appréciation psychiatrique étendue avec ancrage, BPRS-E(A). L'Encéphale, 36(4), 294–301. https://doi.org/10.1016/j.encep.2009.04.003
Mucci, A., Vignapiano, A., Bitter, I., Austin, S. F., Delouche, C., Dollfus, S., … Galderisi, S. (2019). A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale. European Neuropsychopharmacology, 29(8), 947–959. https://doi.org/10.1016/j.euroneuro.2019.05.006
Oei, T. P. S., & Shuttlewood, G. J. (1999). Development of a satisfaction with therapy and therapist scale. Australian and New Zealand Journal of Psychiatry, 33, 748–753. https://doi.org/10.1046/j.1440-1614.1999.00628.x
Rector, N. A., Beck, A. T., & Stolar, N. (2005). The negative symptoms of schizophrenia: A cognitive perspective. The Canadian Journal of Psychiatry, 50(5), 247–257. https://doi.org/10.1177/070674370505000503
Riehle, M., Pillny, M., & Lincoln, T. M. (2017). Ist Negativsymptomatik bei Schizophrenie überhaupt behandelbar? Ein systematisches Literaturreview zur Wirksamkeit psychotherapeutischer Interventionen für Negativsymptomatik. Verhaltenstherapie, 27(3), 199–208. https://doi.org/10.1159/000478534
Rinaldi, R., & Lefebvre, L. (2016). Goal-directed behaviors in patients with schizophrenia: Concept relevance and updated model. Psychiatry and Clinical Neurosciences, 70(9), 394–404. https://doi.org/10.1111/pcn.12401
Savill, M., Orfanos, S., Reininghaus, U., Wykes, T., Bentall, R., & Priebe, S. (2016). The relationship between experiential deficits of negative symptoms and subjective quality of life in schizophrenia. Schizophrenia Research, 176(2–3), 387–391. https://doi.org/10.1016/j.schres.2016.06.017
