Reference : Interobserver agreement of [(68)Ga]Ga-PSMA-11 PET/CT images interpretation in men wit...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/246150
Interobserver agreement of [(68)Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer.
English
Derwael, Celine mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > Service médical de médecine nucléaire et imagerie onco >]
Lavergne, Olivier [> >]
LOVINFOSSE, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > Service médical de médecine nucléaire et imagerie onco >]
Nechifor, Vlad [Université de Liège - ULiège > Département des sciences cliniques > Urologie >]
Salvé, Mallory mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Waltregny, David mailto [Université de Liège - ULiège > Département des sciences cliniques > Urologie >]
Hustinx, Roland mailto [Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire >]
WITHOFS, Nadia mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > Service médical de médecine nucléaire et imagerie onco >]
2020
EJNMMI Research
10
1
15
Yes (verified by ORBi)
2191219X
Germany
[en] Criteria ; Interobserver agreement ; Interpretation ; PROMISE ; PSMA PET ; PSMA-RADS ; Standardized evaluation ; miTNM
[en] BACKGROUND: Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [(68)Ga]Ga-PSMA-11 PET/CT images interpretation according to PC molecular imaging standardized evaluation (PROMISE) criteria and reproducibility of PSMA reporting and data systems (RADS). METHODS: Forty-three patients with newly diagnosed, histologically proven intermediate- or high-risk PC, eligible for radical prostatectomy and who underwent [(68)Ga]Ga-PSMA-11 PET/CT before surgery were retrospectively included. Three nuclear medicine physicians (2 experienced and 1 resident) independently reviewed PET/CT images. Interpretation of [(68)Ga]Ga-PSMA-11 PET/CT images was based on PROMISE criteria including miTNM staging and lesions miPSMA expression score visual estimation and PSMA-RADS version 1.0 for a given scan. Readers' agreement was measured using Krippendorff's coefficients RESULTS: Agreement between observers was almost perfect (coefficient >/= 0.81) for miM; it was substantial (coefficient >/= 0.61) for the following criteria: miT, miN, PSMA-RADS, and miPSMA expression score of primary PC lesion and metastases. However, agreement was moderate (coefficient = 0.41-0.60) for miPSMA score of positive lymph nodes and for detection of PC primary lesion. CONCLUSION: Visual interpretation of [(68)Ga]Ga-PSMA-11 PET/CT images in patients with newly diagnosed PC in a clinical setting leads to at least substantial agreement for PROMISE criteria and PSMA-RADS classification except for PC primary lesion detection and for miPSMA expression scoring of positive lymph nodes that might have been hampered by the interindividual variability of reference organs PSMA expression.
http://hdl.handle.net/2268/246150
10.1186/s13550-020-0596-4

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