Article (Scientific journals)
Curcumin-loaded polysaccharides-based complex particles obtained by polyelectrolyte complexation and ionic gelation. I-Particles obtaining and characterization
Iurciuc-Tincu, Camelia-Elena; Atanase Ionut, Leonard; Ochiuz, Lăcrămioara et al.
2020In International Journal of Biological Macromolecules, 147, p. 629-642
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Keywords :
organic particle; chitosan
Abstract :
[en] Curcumin has essential therapeutic benefits, but it is insoluble in water and thus has low bioavailability. This study aimed to immobilize curcumin into new polysaccharide-based microparticles (gellan, i-carrageenan, and chitosan) to increase its stability and bioavailability. Curcumin-loaded complex microparticles were obtained from three polysaccharides, of different ionic character, by ionic cross-linking and polyelectrolyte complexation. The immobilization efficiency was between 85.75% and 97.25%. The microparticles were characterized morphologically by SEM, and it was observed that the microparticles containing the i-carrageenan had a more pronounced porosity of the matrix. The swelling degree values at pH = 7.4 were superior to those obtained at pH = 6.8 or pH = 2 and depend on both the cross-linking degree and particles morphology. The polysaccharides microparticles, curcumin, and constituent polysaccharides were characterized by FT-IR spectroscopy. The curcumin release kinetics was studied in three different pH media, and the release efficiency ranged between 65.1% and 97.9% at pH = 7.4, between 60.2% and 82.2% at pH = 6.8 and between 56.1% and 64.0% at pH = 2. These microparticles can be intended for oral administration, having as therapeutic target the colon, for the controlled release of curcumin, since they can overcome the gastric barrier without the degradation of the active principle, which is protected by the polymer matrix. © 2020 Elsevier B.V.
Research center :
Center for Education and Research on Macromolecules (CERM)
CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Iurciuc-Tincu, Camelia-Elena;  University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, Iaşi, Romania > Gheorghe Asachi Technical University, Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, Iaşi, Romania
Atanase Ionut, Leonard;  University Apollonia, Faculty of Dental Medicine, Iasi, Romania
Ochiuz, Lăcrămioara;  University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, Iaşi, Romania
Jérôme, Christine  ;  University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit, Center for Education and Research on Macromolecules (CERM), Belgium
Sol, Vincent;  University of Limoges, Faculté des Sciences et Techniques, LCSN, Limoges, France
Martin, Patick;  University of Artois, Unité Transformations & Agroressources, Béthune, France
Popa, Marcel;  Gheorghe Asachi Technical University, Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, Iaşi, Romania > University Apollonia, Faculty of Dental Medicine, Iasi, Romania > Academy of Romanian Scientists, Bucharest, Romania
Language :
English
Title :
Curcumin-loaded polysaccharides-based complex particles obtained by polyelectrolyte complexation and ionic gelation. I-Particles obtaining and characterization
Publication date :
15 March 2020
Journal title :
International Journal of Biological Macromolecules
ISSN :
0141-8130
Publisher :
Elsevier B.V.
Volume :
147
Pages :
629-642
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 March 2020

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