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Deficient Habituation of Evoked Cortical Potentials in Migraine: A Link between Brain Biology, Behavior and Trigeminovascular Activation?
Schoenen, Jean
1996In Biomedicine and Pharmacotherapy, 50 (2), p. 71-8
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Keywords :
Cerebral Cortex/physiopathology; Evoked Potentials; Habituation, Psychophysiologic; Humans; Migraine Disorders/metabolism/physiopathology; Serotonin/metabolism; Trigeminal Nerve/blood supply/physiopathology
Abstract :
[en] According to recent evoked potential studies, a fundamental, probably protective, feature of cortical information processing, ie, response habituation during stimulus repetition, is abnormal in migraine between attacks. The deficient habituation is found for different sensory modalities and experimental paradigms: pattern-reversal visual evoked potentials (same stimulus at a constant intensity), cortical auditory evoked potentials (same stimulus at increasing intensities) and auditory event-related potentials obtained in a passive "oddball" paradigm (novel stimulus). The abnormal information processing is an interictal cortical dysfunction most likely due to inadequate control by the so-called "state-setting, chemically-addressed pathways" originating in the brain stem, in particular by the serotonergic pathway, leading to a low preactivation level of sensory cortices. We suggest that it may play a pivotal role in migraine pathogenesis in conjunction with the reported decrease of brain mitochondrial energy reserve, by favouring a rupture of metabolic homeostasis and biochemical shifts capable of activating the trigeminovascular system and thus capable of producing a migraine attack. We postulate that both the deficient habituation in information processing and the deranged oxygen metabolism may have behavioral correlates. Which of these abnormalities are inherited, acquired or both remains to be determined.
Disciplines :
Neurology
Neurosciences & behavior
Author, co-author :
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Deficient Habituation of Evoked Cortical Potentials in Migraine: A Link between Brain Biology, Behavior and Trigeminovascular Activation?
Publication date :
1996
Journal title :
Biomedicine and Pharmacotherapy
ISSN :
0753-3322
eISSN :
1950-6007
Publisher :
Elsevier Masson, France
Volume :
50
Issue :
2
Pages :
71-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 September 2009

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