Source monitoring for actions in adolescents with 22q11.2 deletion syndrome (22q11DS)

Memory; Schizophrenia; Self-monitoring; VCFS; Adolescent; Attention; Awareness; Chromosome Deletion; Chromosomes, Human, Pair 22; Cognition Disorders; Confusion; Culture; DiGeorge Syndrome; Female; Hallucinations; Humans; Imagination; Internal-External Control; Male; Mental Recall; Personal Construct Theory; Risk Factors; Schizophrenic Psychology

Abstract :

[en] Background. Source monitoring consists in identifying the origin of mental events. Recent research suggests that confusions over internally generated mental events may represent a cognitive marker for increased proneness to psychotic symptoms and disorders. We have examined source monitoring for actions in adolescents with the 22q11.2 deletion syndrome (22q11DS), a neurogenetic disease associated with high rates of schizophrenia during adulthood, and expected to observe source monitoring deficits in comparison to IQ-matched and typically developing controls. Method. Eighteen adolescents with 22q11DS, 17 adolescents matched for age and IQ, and also 17 adolescents matched for age participated in this study. Our adapted action monitoring paradigm asked subjects to visualize a series of actions in three different conditions: (1) visualize themselves performing the action; (2) visualize the experimenter performing the action; or (3) simply repeat the action statements without visualization of the action performer. Results. The adolescents with 22q11DS performed adequately in terms of recognition (hits), but in comparison to both control groups, they committed more source confusions on correctly recognized items. Further examination revealed that the adolescents were more likely to demonstrate confusions between exterior sources in which the self was not involved. Conclusions. Source monitoring deficits can be observed in adolescents with 22q11DS, a syndrome putting them at high risk for developing schizophrenia. These deficits are discussed in terms of early cognitive processes associated with genetic risk for schizophrenia. © 2007 Cambridge University Press.

Disciplines :

Neurosciences & behavior

Author, co-author :

Debbané, Martin; Service Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Switzerland, Faculty of Psychology, University of Geneva, Switzerland, Service Médico-Pédagogique, Department of Psychiatry, University of Geneva School of Medicine, 1618 Boulevard St-Georges, 1211 Geneva 8, Switzerland

Van der Linden, Martial ; Université de Liège - ULiège > Département de Psychologie > Département de Psychologie

Glaser, Bronwyn; Service Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Switzerland, Faculty of Psychology, University of Geneva, Switzerland

Eliez, Stéphan; Service Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Switzerland, Department of Genetic Medicine and Development, University of Geneva School of Medicine, Switzerland

Language :

English

Title :

Source monitoring for actions in adolescents with 22q11.2 deletion syndrome (22q11DS)

Publication date :

2008

Journal title :

Psychological Medicine

ISSN :

0033-2917

eISSN :

1469-8978

Publisher :

Cambridge University Press, United Kingdom

Volume :

Issue :

Pages :

811-820

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 01 March 2020

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Bibliography

Allen PP, Johns LC, Fu CH, Broome MR, Vythelingum GN, McGuire PK (2004). Misattribution of external speech in patients with hallucinations and delusions. Schizophrenia Research 69, 277-287.
Axelrod SR, Grilo CM, Sanislow C, McGlashan TH (2001). Schizotypal Personality Questionnaire-Brief: factor structure and convergent validity in inpatient adolescents. Journal of Personality Disorders 15, 168-179.
Baker KD, Skuse DH (2005). Adolescents and young adults with 22q11 deletion syndrome: psychopathology in an at-risk group. British Journal of Psychiatry 186, 115-120.
Bassett AS, Chow EW, AbdelMalik P, Gheorghiu M, Husted J, Weksberg R (2003). The schizophrenia phenotype in 22q11 deletion syndrome. American Journal of Psychiatry 160, 1580-1586.
Bentall RP, Baker GA, Havers S (1991). Reality monitoring and psychotic hallucinations. British Journal of Clinical Psychology 30, 213-222.
Bentall RP, Kinderman P, Kaney S (1994). The self, attributional processes and abnormal beliefs: towards a model of persecutory delusions. Behaviour Research and Therapy 32, 331-341.
Brébion G, Amador X, David A, Malaspina D, Sharif Z, Gorman JM (2000). Positive symptomatology and source-monitoring failure in schizophrenia - an analysis of symptom-specific effects. Psychiatry Research 95, 119-131.
Brébion G, Gorman JM, Amador X, Malaspina D, Sharif Z (2002). Source monitoring impairments in schizophrenia: characterisation and associations with positive and negative symptomatology. Psychiatry Research 112, 27-39.
Brébion G, Gorman JM, Malaspina D, Amador X (2005). A model of verbal memory impairments in schizophrenia: two systems and their associations with underlying cognitive processes and clinical symptoms. Psychological Medicine 35, 133-142.
Brunelin J, Combris M, Poulet E, Kallel L, D'Amato T, Dalery J, Saoud M (2006). Source monitoring deficits in hallucinating compared to non-hallucinating patients with schizophrenia. European Psychiatry 21, 259-261.
Cornblatt B, Obuchowski M, Roberts S, Pollack S, Erlenmeyer-Kimling L (1999). Cognitive and behavioral precursors of schizophrenia. Developmental Psychopathology 11, 487-508.
Debbané M, Glaser B, David MK, Feinstein C, Eliez S (2006a). Psychotic symptoms in children and adolescents with 22q11.2 deletion syndrome: neuropsychological and behavioral implications. Schizophrenia Research 84, 187-193.
Debbané M, Glaser B, Eliez S (in press). Encoding and retrieval processes in velo-cardio-facial syndrome (VCFS). Neuropsychology.
Debbané M, Schaer M, Farhoumand R, Glaser B, Eliez S (2006b). Hippocampal volume reduction in 22q11.2 deletion syndrome. Neuropsychologia 44, 2360-2365.
Dumas P, Bouafia S, Gutknecht C, Saoud M, Dalery J, d'Amato T (2000). Validation of the French version of the Raine Schizotypal Personality Disorder Questionnaire - categorical and dimensional approach to schizotypal personality traits in a normal student population [in French]. Encephale 26, 23-29.
Franck N, Rouby P, Daprati E, Dalery J, Marie-Cardine M, Georgieff N (2000). Confusion between silent and overt reading in schizophrenia. Schizophrenia Research 41, 357-364.
Freeman D, Garety PA, Kuipers E, Fowler D, Bebbington PE (2002). A cognitive model of persecutory delusions. British Journal of Clinical Psychology 41, 331-347.
Frith C, Done J (1989). Positive symptoms of schizophrenia. British Journal of Psychiatry 154, 569-570.
Frith CD (1992). The Cognitive Neuropsychology of Schizophrenia. Psychology Press Ltd: Hove.
Glaser B, Mumme DL, Blasey C, Morris MA, Dahoun SP, Antonarakis SE, Reiss AL, Eliez S (2002). Language skills in children with velocardiofacial syndrome (deletion 22q11.2). Journal of Pediatrics 140, 753-758.
Golding-Kushner KJ, Weller G, Shprintzen RJ (1985). Velo-cardio-facial syndrome: language and psychological profiles. Journal of Craniofacial Genetics and Developmental Biology 5, 259-266.
Gothelf D, Eliez S, Thompson T, Hinard C, Penniman L, Feinstein C, Kwon H, Jin S, Jo B, Antonarakis SE, Morris MA, Reiss AL (2005). COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. Nature Neuroscience 8, 1500-1502.
Henquet C, Krabbendam L, Dautzenberg J, Jolles J, Merckelbach H (2005). Confusing thoughts and speech: source monitoring and psychosis. Psychiatry Research 133, 57-63.
Johns LC, van Os J (2001). The continuity of psychotic experiences in the general population. Clinical Psychology Review 21, 1125-1141.
Johnson MK, Hashtroudi S, Lindsay DS (1993). Source monitoring. Psychological Bulletin 114, 3-28.
Johnson MK, Raye CL (2000). Cognitive and brains mechanisms of false memories and beliefs. In Memory, Brain and Belief (ed. D. L. Schacter and E. Scarry), pp. 35-86. Harvard University Press: Cambridge, MA.
Joyce EM, Roiser JP (2007). Cognitive heterogeneity in schizophrenia. Current Opinion in Psychiatry 20, 268-272.
Kates WR, Burnette CP, Jabs EW, Rutberg J, Murphy AM, Grados M, Geraghty M, Kaufmann WE, Pearlson GD (2001). Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis. Biological Psychiatry 49, 677-684.
Kaufman AS, Kaufman JC, Balgopal R, McLean JE (1996). Comparison of three WISC-III short-forms: weighing psychometric, clinical, and practical factors. Journal of Clinical Child Psychology 25, 97-105.
Kendler KS, McGuire M, Gruenberg AM, Walsh D (1994). Clinical heterogeneity in schizophrenia and the pattern of psychopathology in relatives: results from an epidemiologically based family study. Acta Psychiatrica Scandinavica 89, 294-300.
Larøi F, Collignon O, Van der Linden M (2005). Source monitoring for actions in hallucination proneness. Cognitive Neuropsychiatry 10, 105-123.
Larøi F, Van der Linden M, Marczewski P (2004). The effects of emotional salience, cognitive effort and meta-cognitive beliefs on a reality monitoring task in hallucination-prone subjects. British Journal of Clinical Psychology 43, 221-233.
Lemos Giraldez S, Caro MI, Lopez Rodrigo AM, Pineiro MP, Gonzalez JL (2000). Assessment of essential components of schizotypy using neurocognitive measures. Psychology in Spain 4, 183-194.
Lewandowski KE, Shashi V, Berry PM, Kwapil TR (2006). Schizophrenic-like neurocognitive deficits in children and adolescents with 22q11 deletion syndrome. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144, 27-36.
Moss EM, Batshaw ML, Solot CB, Gerdes M, McDonald-McGinn DM, Driscoll DA, Emanuel BS, Zackai EH, Wang PP (1999). Psychoeducational profile of the 22q11.2 microdeletion: a complex pattern. Journal of Pediatrics 134, 193-198.
Murphy KC (2005). Annotation: velo-cardio-facial syndrome. Journal of Child Psychology and Psychiatry 46, 563-571.
Murphy KC, Jones LA, Owen MJ (1999). High rates of schizophrenia in adults with velo-cardio-facial syndrome. Archives of General Psychiatry 56, 940-945.
Oskarsdottir S, Vujic M, Fasth A (2004). Incidence and prevalence of the 22q11 deletion syndrome: a population-based study in Western Sweden. Archives of Disease in Childhood 89, 148-151.
Raine A (1991). The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin 17, 555-564.
Rossi A, Daneluzzo E (2002). Schizotypal dimensions in normals and schizophrenic patients: a comparison with other clinical samples. Schizophrenia Research 54, 67-75.
Saint-Laurent L (1990). Psychometric study of Kovacs' Children's Depression Inventory with a French-speaking sample [in French]. Canadian Journal of Behavioral Science 22, 377-384.
Simon TJ, Bish JP, Bearden CE, Ding L, Ferrante S, Nguyen V, Gee JC, McDonald-McGinn DM, Zackai EH, Emanuel BS (2005a). A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children. Developmental Psychopathology 17, 753-784.
Simon TJ, Ding L, Bish JP, McDonald-McGinn DM, Zackai EH, Gee J (2005b). Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study. Neuroimage 25, 169-180.
Swillen A, Devriendt K, Legius E, Eyskens B, Dumoulin M, Gewillig M, Fryns JP (1997). Intelligence and psychosocial adjustment in velocardiofacial syndrome: a study of 37 children and adolescents with VCFS. Journal of Medical Genetics 34, 453-458.
Swillen A, Vandeputte L, Cracco J, Maes B, Ghesquiere P, Devriendt K, Fryns JP (1999). Neuropsychological, learning and psychosocial profile of primary school aged children with the velo-cardio-facial syndrome (22q11 deletion): evidence for a nonverbal learning disability? Child Neuropsychology 5, 230-241.
Taylor JL, John CH (2004). Attentional and memory bias in persecutory delusions and depression. Psychopathology 37, 233-241.
Turgeon L, Chartrand E (2003). Reliability and validity of the revised children's manifest anxiety scale in a French-Canadian sample. Psychological Assessment 15, 378-383.
Vinogradov S, Willis-Shore J, Poole JH, Marten E, Ober BA, Shenaut GK (1997). Clinical and neurocognitive aspects of source monitoring errors in schizophrenia. American Journal of Psychiatry 154, 1530-1537.
Vogeley K, May M, Ritzl A, Falkai P, Zilles K, Fink GR (2004). Neural correlates of first-person perspective as one constituent of human self-consciousness. Journal of Cognitive Neuroscience 16, 817-827.
Yonelinas AP (2001). Components of episodic memory: the contribution of recollection and familiarity. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 356, 1363-1374.