Vitamin D Supplementation in France in patients with or at risk for osteoporosis: Recent data and new practices

[en] With intermittent vitamin D supplementation, serum 25-hydroxyvitamin D (25OHD)levels may remain stable only if the dosing interval is shorter than 3 months, the ideal perhaps being about 1 month. Recent data support moderate daily vitamin D doses instead of high intermittent doses, notably in elderly patients prone to falls. The level of evidence is low, however, with no head-to-head comparisons of clinical outcomes such as fractures and falls in groups given identical dosages daily versus intermittently. A challenge to daily vitamin D supplementation in France is the absence of a suitable pharmaceutical formulation. In addition, daily dosing carries a high risk of poor adherence. Until suitable vitamin D3 formulations such as tablets or soft capsules each containing 1000 or 1500 IU become available, we suggest intermittent supplementation according to 2011 GRIO guidelines. Among the available dosages, the lowest should be preferred, with the shortest possible interval, e.g., 50,000 IU monthly rather than 100,000 every two months. © 2019 Société française de rhumatologie

Disciplines :

Laboratory medicine & medical technology

Author, co-author :

Souberbielle, Jean-Claude; Service d'explorations fonctionnelles, hôpital Necker-Enfants malades, AP–HP, Paris, 75015, France

Cormier, Catherine; Rheumatology unit, Cochin Hospital, 27, rue du Faubourg Saint-Jacques, Paris, 75014, France

Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Breuil, Véronique; Université Côte D'Azur, Service de rhumatologie, CHU de Nice, BIAM- UMR E 4320 TIRO-MATOs, CEA/UNS, centre hospitalier universitaire Nice, Nice, 06000, France

Debiais, Françoise; Service de rhumatologie, CHU de Poitiers, Poitiers, 86021, France

Fardellone, Patrice; Service de rhumatologie, CHU de Amiens, hôpital Nord, place Victor Pauchet, Amiens cedex 1, 80054, France

Guggenbuhl, Pascal; Institut NUMECAN, Inserm U 1241, Inra U 1341, Service de rhumatologie, hôpital Sud, CHU, Université de Rennes 1, Rennes, 35000, France

Javier, Rose-Marie; Service de rhumatologie, hôpitaux universitaires de Strasbourg, hôpital de Hautepierre, 1 avenue Molière, Strasbourg, 67200, France

Legrand, Érick; Service de rhumatologie, CHU d'Angers, Angers, 49000, France

Lespessailles, Éric; Service de rhumatologie, CHR Orléans, EA 4708 I3MTO, Université d'Orléans, Orléans, 45067, France

More authors (4 more)

Language :

English

Title :

Vitamin D Supplementation in France in patients with or at risk for osteoporosis: Recent data and new practices

Publication date :

2019

Journal title :

Joint Bone Spine

ISSN :

1297-319X

eISSN :

1778-7254

Publisher :

Elsevier Masson SAS

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 February 2020

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