Article (Scientific journals)
G1 is the major APOL1 risk allele for hypertension-attributed nephropathy in Central Africa.
Sumaili, Ernest K.; Shemer, Revital; Kruzel-Davila, Etty et al.
2019In Clinical Kidney Journal, 12 (2), p. 188-195
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Keywords :
APOL1 risk variants; CKD; Kinshasa; Trypanosoma brucei gambiense; hypertension
Abstract :
[en] Background: Sub-Saharan Africans exhibit a higher frequency of chronic kidney disease (CKD) than other populations. In this study, we sought to determine the frequency of apolipoprotein L1 (APOL1) genotypes in hypertension-attributed CKD in Kinshasa, Democratic Republic of the Congo. Methods: We performed a case-control study identifying 162 subjects: 79 with hypertension-attributed CKD and 83 controls living in Kinshasa who were genotyped for APOL1 risk variants between July 2013 and November 2016. We selected control subjects from the general population and matched them with the cases according to age. Logistic regression analysis was used to examine the relationship between APOL1 high-risk genotypes and CKD. Results: The frequencies of the APOL1 G1 and G2 alleles were 19.1 and 7.1%, respectively. The number of individuals with the G1 and G2 risk alleles was significantly higher in the CKD group (12.7%) than in the control group (2.4%), particularly in individuals with end-stage kidney disease (14.3%). Subjects carrying two risk alleles was strongly and independently associated with hypertension-attributed nephropathy, with an adjusted odds ratio of 7.7 (95% confidence interval 1.5-39.7; P = 0.014). The high-risk APOL1 genotypes were G1/G1 and G1/G2, whereas G2/G2 was not found in the study population. Conclusions: The results of this study demonstrate the association of high-risk APOL1 genotypes with kidney disease in Kinshasa. The absence of G2/G2 may be consistent with powerful selective sweeps induced by Trypanosoma brucei gambiense infection. In contrast, the presence of APOL1 G2/G2 among individuals of African ancestry in the USA may indicate relaxation of natural selection in a trypanosome-free environment.
Disciplines :
Laboratory medicine & medical technology
Urology & nephrology
Author, co-author :
Sumaili, Ernest K.
Shemer, Revital
Kruzel-Davila, Etty
Cohen, Eric P.
Mutantu, Pierre N.
Bukabau, Justine B.
Makulo, Jean Robert R.
Mokoli, Vieux M.
Luse, Jeannine L.
Pakasa, Nestor M.
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Wumba, Roger D.
Reiner-Benaim, Anat
Boner, Geoffrey
Lifschitz, Meyer
Nseka, Nazaire M.
Skorecki, Karl
Wasser, Walter G.
More authors (8 more) Less
Language :
English
Title :
G1 is the major APOL1 risk allele for hypertension-attributed nephropathy in Central Africa.
Publication date :
2019
Journal title :
Clinical Kidney Journal
ISSN :
2048-8505
eISSN :
2048-8513
Publisher :
Oxford University Press, United Kingdom
Volume :
12
Issue :
2
Pages :
188-195
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 February 2020

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