Article (Scientific journals)
Estimated glomerular filtration rate using a point of care measure of creatinine in patients with iohexol determinate GFR
STOJKOVIC, Violeta; Delanaye, Pierre; COLLARD, Grégory et al.
2019In Clinica Chimica Acta, 499, p. 123-127
Peer Reviewed verified by ORBi
 

Files


Full Text
StojkovicCCA2019.pdf
Publisher postprint (2.9 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Creatinine; Glomerular filtration rate; Iohexol; Point of care; Article; Chronic Kidney Disease and Epidemiology equation
Abstract :
[en] Introduction: Determination of creatinine and estimation of Glomerular Filtration Rate (GFR) rapidly before injection of contrast media provides early detection of high-risk patients for acute kidney failure. Hence, a rapid point-of-care (POC) device (result in 30 s) allowing creatinine measurement and eGFR could be of interest. To validate this method, we considered a population referred for measuring GFR. Methods: Iohexol plasma clearance was used to measure GFR. For each subject, enzymatic creatinine was quantified with two different devices: in plasma with the Roche Cobas analyzer and in capillary blood with the Nova Biomedical POC device. Both values of creatinine were used in the CKD-EPI equation for estimated glomerular filtration rate (eGFR). eGFR using POC was compared to eGFR using Cobas and to mGFR by Passing Bablok regression, calculation of bias, precision and accuracy (or concordance) within 30%. Also, we calculated the rate of discrepant staging (eGFR >60 or ≤ 60 when mGFR is actually ≤60 and > 60) with both creatinine methods. Results: 120 subjects (52 ± 13 years, 49% of women) were included. Mean mGFR was 77 ± 27 mL/min/1.73m2 with 29 patients presenting mGFR <60 mL/min/1.73m2. Passing- Bablok regression comparing eGFR obtained with the POC and the Cobas was: eGFRPOC = −0.1 (95% CI: −7.4; 3.0) + 1.06 (95% CI: 1.00; 1.15) x eGFRCOBAS. Mean bias was 3.7 ± 14.1 mL/min/1.73m2. Concordance within 30% was 82%. Compared to mGFR, Passing-Bablok with POC was: eGFRPOC = −11.5 (95% CI: −22.9; −0.7) + 1.15 (95% CI: 1.02; 1.29) x mGFR. Mean bias was 0.1 ± 17.6 mL/min/1.73m2. Accuracy within 30% was 81%. Between eGFRCOBAS and mGFR, mean bias was −3.7 ± 12.5 mL/min/1.73m2. Accuracy within 30% was 95%. With POC (and Cobas), 3.3% (0.8%) of patients would have been considered with GFR > 60 mL/min/1.73m2 whereas mGFR it was ≤60 and 10% (9.2%) of them would have been considered with GFR ≤60 mL/min/1.73m2 when mGFR was >60. Conclusion: Creatinine measured with the POC has an acceptable performance when used with the CKD-EPI equation to estimate GFR. Its ability to detect GFR <60 mL/min/1.73m2 is not significantly different from the classical Roche assay. StatSensor Creatinine (Nova Biomedical) can be used for GFR screening before contrast media injection. © 2019 Elsevier B.V.
Disciplines :
Urology & nephrology
Laboratory medicine & medical technology
Author, co-author :
STOJKOVIC, Violeta ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Pool assistant - biologie clinique
Delanaye, Pierre  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
COLLARD, Grégory ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire techniques séparatives et stress oxydant
FERRANTE, Nunzio ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire techniques séparatives et stress oxydant
Le Goff, Caroline  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
Lutteri, Laurence ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Estimated glomerular filtration rate using a point of care measure of creatinine in patients with iohexol determinate GFR
Publication date :
2019
Journal title :
Clinica Chimica Acta
ISSN :
0009-8981
eISSN :
1873-3492
Publisher :
Elsevier B.V.
Volume :
499
Pages :
123-127
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 February 2020

Statistics


Number of views
70 (8 by ULiège)
Number of downloads
3 (3 by ULiège)

Scopus citations®
 
12
Scopus citations®
without self-citations
12
OpenCitations
 
10

Bibliography


Similar publications



Contact ORBi