Benchmarking of Survival Outcomes following Haematopoietic Stem Cell Transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)
Snowden, John A.; Saccardi, Riccardo; Orchard, Kimet al.
2020 • In Bone Marrow Transplantation, 55, p. 681-694
[en] In many healthcare settings, benchmarking for complex procedures has become a mandatory requirement by competent authorities, regulators, payers and patients to assure clinical performance, cost-effectiveness and safe care of patients. In several countries inside and outside Europe, benchmarking systems have been established for haematopoietic stem cell transplantation (HSCT), but access is not universal. As benchmarking is now integrated into the FACT-JACIE standards, the EBMT and JACIE established a Clinical Outcomes Group (COG) to develop and introduce a universal system accessible across EBMT members. Established systems from seven European countries (United Kingdom, Italy, Belgium, France, Germany, Spain, Switzerland), USA and Australia were appraised, revealing similarities in process, but wide variations in selection criteria and statistical methods. In tandem, the COG developed the first phase of a bespoke risk-adapted international benchmarking model for one-year survival following allogeneic and autologous HSCT based on current capabilities within the EBMT registry core dataset. Data completeness, which has a critical impact on validity of centre comparisons, is also assessed. Ongoing development will include further scientific validation of the model, incorporation of further variables (when appropriate) alongside implementation of systems for clinically meaningful interpretation and governance aiming to maximise acceptance to centres, clinicians, payers and patients across EBMT.
Disciplines :
Hematology
Author, co-author :
Snowden, John A.
Saccardi, Riccardo
Orchard, Kim
Ljungman, Per
Duarte, Rafael F.
Labopin, Myriam
McGrath, Eoin
Brook, Nigel
Ruiz de Elvira, Carmen
Gordon, Debra
Poirel, Hélène A.
Ayuk, Francis
Beguin, Yves ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie
Benchmarking of Survival Outcomes following Haematopoietic Stem Cell Transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)
Wind A, van Harten WH. Benchmarking specialty hospitals, a scoping review on theory and practice. BMC Health Serv Res 2017;17:245.
Wind A, Gonçalves FR, Marosi E, da Pieve L, Groza M, Asioli M, et al. Benchmarking cancer centers: from care pathways to integrated practice units. J Natl Compr Cancer Netw 2018;16:1075–83.
Henneman D, Dekker JWT, Wouters MWJM, Fiocco M, Tollenaar RAEM. Benchmarking clinical outcomes in elective colorectal cancer surgery: The interplay between institutional reoperation- and mortality rates. Eur J Surg Oncol. 2014;40:1429–35.
Stortz JA, Mira JC, Raymond SL, Loftus TJ, Ozrazgat-Baslanti T, Wang Z, et al. Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients. J Trauma Acute Care Surg 2018;84:342–9.
Choi D, Crockard HA. How and why should we benchmark clinical outcomes and quality of life for surgery in spinal metastases? Br J Neurosurg 2009;23:3–4.
Ettorchi-Tardy A, Levif M, Michel P. Benchmarking: a method for continuous quality improvement in health. Health Policy|Polit Sté. 2012;7:E101–19.
Thonon F, Watson J, Saghatchian M. Benchmarking facilities providing care: an international overview of initiatives. SAGE Open Med 2015;3:205031211560169.
Crysandt M, Yakoub-Agha I, Reiß P, Theisen S, Silling G, Glatte P, et al. How to build an allogeneic hematopoietic cell transplant unit in 2016: proposal for a practical framework. Curr Res Transl Med 2017;65:149–54.
Horan JT, Logan BR, Agovi-Johnson M-A, Lazarus HM, Bacigalupo AA, Ballen KK, et al. Reducing the risk for transplantation-related mortality after allogeneic hematopoietic cell transplantation: how much progress has been made? J Clin Oncol 2011;29:805–13.
Schetelig J, de Wreede LC, Andersen NS, Moreno C, van Gelder M, Vitek A, et al. Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT). Br J Haematol 2017;178:521–33.
Kharfan-Dabaja MA, Aljurf M. Hematopoietic cell transplantation: training challenges and potential opportunities through networking and integration of modern technologies to the practice setting. Hematol Oncol Stem Cell Ther 2017;10:184–8.
Marks PW, Witten CM, Califf RM. Clarifying stem-cell therapy’s benefits and risks. N Engl J Med 2017;376:1007–9.
Yafour N, Beckerich F, Bulabois CE, Chevallier P, Daguindau E, Dumesnil C, et al. How to prevent relapse after allogeneic hematopoietic stem cell transplantation in patients with acute leukemia and myelodysplastic syndrome. Curr Res Transl Med 2017;65:65–69.
Gratwohl A, Brand R, Niederwieser D, Baldomero H, Chabannon C, Cornelissen J, et al. Introduction of a quality management system and outcome after hematopoietic stem-cell transplantation. J Clin Oncol. 2011;29:JCO.2010.30.4121.
Gratwohl A, Brand R, McGrath E, van Biezen A, Sureda A, Ljungman P, et al. Use of the quality management system “JACIE” and outcome after hematopoietic stem cell transplantation. Haematologica. 2014;99:908–15.
LeMaistre CF, Wacker KK, Akard LP, Al-Homsi AS, Gastineau DA, Godder K, et al. Integration of publicly reported center outcomes into standards and accreditation: the FACT model. Biol Blood Marrow Transplant 2019.
Passweg J, Baldomero H, Stern M, Bargetzi M, Ghielmini M, Leibundgut K, et al. Hematopoietic stem cell transplantation in Switzerland: a comprehensive quality control report on centre effect. Swiss Med Wkly 2010;140:326–34.
Poirel HA, Vanspauwen M, Macq G, De Geyndt A, Maertens J, Willems E, et al. Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres. Bone Marrow Transpl 2019;54:1434–42.
Armand P, Kim HT, Logan BR, Wang Z, Alyea EP, Kalaycio ME, et al. Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation. Blood 2014;123:3664–71.
Shouval R, Fein JA, Labopin M, Kroeger N, Duarte RF, Bader P, et al. The Disease Risk Index is a robust tool for allogeneic hematopoietic stem cell transplantation risk stratification: an independent validation study on a large cohort of the European Society for Blood and Marrow Transplantation (EBMT). Blood. 2016;128:988.
Gratwohl A, Duarte RF, Snowden JA, van Biesen A, Baldomero H, Apperley J, et al. Pre-transplantation risks and transplant-techniques in haematopoietic stem cell transplantation for acute leukaemia. E-Clin Med 2019.
Spiegelhalter DJ. Funnel plots for comparing institutional performance. Stat Med. 2005;24:1185–202.
Clark TG, Altman DG, Stavola BL De. Quantification of the completeness of follow-up. Lancet. 2002;359:1309–10.
Passweg JR, Baldomero H, Bader P, Basak GW, Bonini C, Duarte R, et al. Is the use of unrelated donor transplantation leveling off in Europe? The 2016 European Society for Blood and Marrow Transplant activity survey report. Bone Marrow Transpl 2018;53:1139–48.
Shouval R, Fein JA, Labopin M, Kroeger N, Duarte RF, Bader P, et al. Outcomes of allogeneic haematopoietic stem cell transplantation from HLA-matched and alternative donors over 15 years: a retrospective analysis of 106, 188 patients on behalf of the European Society for Blood and Marrow Transplantation. Lancet Haematol. 2019.
Duarte RF, Labopin M, Bader P, Basak GW, Bonini C, Chabannon C, et al. Indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2019. Bone Marrow Transplant 2019;54:1525–52.
Passweg JR, Baldomero H, Basak GW, Chabannon C, Corbacioglu S, Duarte R, et al. The EBMT activity survey report 2017: a focus on allogeneic HCT for nonmalignant indications and on the use of non-HCT cell therapies. Bone Marrow Transplant 2019;54:1575–85.
Yakoub-Agha I, Chabannon C, Bader P, Basak G, Bonig H, Ciceri F, et al. Management of adults and children undergoing autologous CAR-T cell therapy: best practice recommendations of the EBMT and JACIE. Haematologica 2019 (under revision).
Gratwohl A, Sureda A, Baldomero H, Gratwohl M, Dreger P, Kröger N, et al. Economics and outcome after hematopoietic stem cell transplantation: a Retrospective Cohort Study. EBioMedicine 2015;2:2101–9.
Pasquini MC, Srivastava A, Ahmed SO, Aljurf M, Atsuta Y, Doleysh C, et al. Worldwide network for blood and marrow transplantation recommendations for establishing a hematopoietic cell transplantation program, Part I: minimum requirements and beyond. Biol Blood Marrow Transplant. 2019.