Article (Scientific journals)
Estimated 24-h urinary sodium and sodium-to-potassium ratio are predictors of kidney function decline in a population-based study
Dériaz, Denis; Guessous, Idris; Vollenweider, Peter et al.
2019In Journal of Hypertension
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Keywords :
renal function decline; salt; sodium; urinary sodium-to-potassium ratio
Abstract :
[en] Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide in part due to population ageing. Identifying risk factors for age-related kidney function decline could help in understanding mechanisms for kidney ageing. Sodium and potassium intakes are associated with CKD progression in the renal population, but little is known on their role in renal function decline [mean estimated glomerular filtration rate variation ([DELTA]eGFR)] in the general adult population. Method: We therefore explored the association of urinary sodium and potassium excretions with [DELTA]eGFR in a longitudinal population-based cohort. We estimated 24-h urinary sodium (eUNa), potassium (eUK) and sodium-to-potassium ratio (eUNa/K) from spot urine using Kawasaki formulae. We performed multivariate linear regression models studying the association of eUNa, eUK and eUNa/K with yearly [DELTA]eGFR, taking several covariates into account, including baseline eGFR and albuminuria. Results: There were 4141 white participants from which 54.3% were women. Median age was 51.5 [43.6-60.6] years and mean baseline eGFR 88 (SD 15) ml/min per 1.73 m2. During a median follow-up of 5.4 years, mean [DELTA]eGFR was -0.59 (SD 1.68) ml/min per 1.73 m2 per year. In the fully adjusted model, high eUNa and eUNa/K were associated with faster renal function decline with standardized coefficients [beta] = -0.07 (95% confidence interval: -0.11 to -0.04) and [beta] = -0.05 (95% confidence interval: -0.08 to -0.02), respectively. By contrast, eUK, taken alone, showed no association. Conclusion: These results suggest that dietary sodium and potassium intakes may play a role in kidney function decline in the general adult population. Whether lowering sodium and increasing potassium in the diet may help in CKD prevention needs further exploration.
Disciplines :
Urology & nephrology
Author, co-author :
Dériaz, Denis ;  Centre Hospitalier Universitaire Vaudois (Lausanne) > Institute of Social and Preventive Medicine (IUMSP)
Guessous, Idris;  Hôpitaux Universitaires de Genève - HUG > Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine and Primary Care and Emergency Medicine
Vollenweider, Peter;  Centre Hospitalier Universitaire Vaudois (Lausanne) > Department of General Internal Medicine
Devuyst, Olivier;  Universität Zürich - UZH > Institute of Physiology
Burnier, Michel;  Centre Hospitalier Universitaire Vaudois (Lausanne) > Service of Nephrology and Hypertension
Bochud, Murielle ;  Centre Hospitalier Universitaire Vaudois (Lausanne) > Institute of Social and Preventive Medicine (IUMSP)
Belén, Ponte ;  Hôpitaux Universitaires de Genève - HUG > Department of Nephrology
 These authors have contributed equally to this work.
Language :
English
Title :
Estimated 24-h urinary sodium and sodium-to-potassium ratio are predictors of kidney function decline in a population-based study
Publication date :
05 April 2019
Journal title :
Journal of Hypertension
ISSN :
0263-6352
eISSN :
1473-5598
Publisher :
Lippincott Williams & Wilkins, United States
Special issue title :
Published Ahead-of-Print
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 February 2020

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