Reference : Interictal cortical excitability in migraine: a study using transcranial magnetic sti...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
Interictal cortical excitability in migraine: a study using transcranial magnetic stimulation of motor and visual cortices.
Afra, Judit [> > > >]
Mascia, Adolores [> > > >]
GERARD, Pascale [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
MAERTENS DE NOORDHOUT, Alain mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Annals of Neurology
Wiley Liss
Yes (verified by ORBi)
New York
[en] Adult ; Differential Threshold ; Electromyography ; Evoked Potentials, Motor ; Female ; Humans ; Isometric Contraction/physiology ; Migraine Disorders/physiopathology ; Motor Cortex/physiology/physiopathology ; Phosphenes ; Physical Stimulation ; Transcranial Magnetic Stimulation ; Ulnar Nerve/physiology/physiopathology ; Visual Cortex/physiology/physiopathology
[en] We performed transcranial magnetic stimulations of the motor and visual cortices in healthy controls (n = 27) and in patients suffering from migraine without (n = 33) or with (n = 25) aura between attacks. By using a 13-cm circular coil placed over the vertex and recordings of the first dorsal interosseus muscle, we measured thresholds (at rest and during contraction), amplitudes of motor evoked potentials and cortical silent periods. Paired stimulations with short (1-20 msec) interstimulus intervals were performed to assess intracortical inhibition. The visual cortex was stimulated with the same coil placed over the occipital scalp (7 cm above the inion) and the prevalence and threshold of phosphene production was determined. In patients with migraine with aura, motor thresholds during isometric contraction were significantly higher, whereas the prevalence of stimulation-induced phosphene production was lower compared with healthy controls. These changes were not correlated with attack frequency or disease duration. No differences were found between subject groups in thresholds at rest, motor evoked potential amplitudes, cortical silent periods, or response curves after paired stimuli. These results are in favor of cortical hypoexcitability rather than hyperexcitability in patients with migraine with aura between attacks.
also: ;

File(s) associated to this reference

Fulltext file(s):

Restricted access
Intercital cortical .pdfPublisher postprint657.27 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.