Article (Scientific journals)
Pharmacothérapie des formes sévères du sevrage éthylique en milieu hospitalier
GENSBURGER, Mathieu; Ghuysen, Alexandre
2019In Revue Médicale de Liège, 74 (5-6), p. 365-372
Peer reviewed
 

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Keywords :
Alpha-2 adrenergic agonist; Benzodiazepine; Delirium tremens; Diazepam; Ethanol withdrawal; Pharmacotherapy; Phenobarbital; Article; Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Humans; Intensive Care Units; Substance Withdrawal Syndrome
Abstract :
[en] Acute alcohol withdrawal is a frequent medical condition among hospitalized patients. Severe forms are associated with significant morbidity and mortality, which can be sharply reduced with proper drug therapy. A good understanding of the pathophysiology as well as the pharmacokinetic and pharmacodynamic properties of the various drug used is paramount. The medications must target the imbalance between inhibitory and excitatory neurotransmitter systems responsible for the clinical picture. Proper drug therapy allows not only rapid symptomatic relief but also limit disease progression and complications while diminishing resource use, notably invasive ventilation and stay duration in the intensive care unit. GABA agonist drugs are the first line treatment, notably benzodiazepines and barbiturates. Other class, such as alpha-2 adrenoreceptor agonists may be used to control the dysautonomic features of the disease but are at best adjunctive. © 2019 Revue Medicale de Liege. All rights reserved.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
GENSBURGER, Mathieu ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service des urgences
Ghuysen, Alexandre ;  Université de Liège - ULiège > Département des sciences de la santé publique > Simulation médicale en situation critique
Title :
Pharmacothérapie des formes sévères du sevrage éthylique en milieu hospitalier
Alternative titles :
[en] Pharmacotherapy of most severe forms of alcohol withdrawal
Publication date :
2019
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Revue Medicale de Liege
Volume :
74
Issue :
5-6
Pages :
365-372
Peer reviewed :
Peer reviewed
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