Article (Scientific journals)
Etude des risques oncologiques associés au syndrome de Lynch en région liégeoise
Lion, L.; LECLERCQ, Philippe; Plomteux, O. et al.
2019In Revue Médicale de Liège, 74 (9), p. 479-483
 

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Keywords :
Age; Lynch Syndrome / HNPCC; Neoplasm; Prevalence
Abstract :
[en] Lynch syndrome is a hereditary predisposition to several cancers. The goals of our study were to know the different mutations in our Lynch population, to evaluate the prevalence of cancers in this population and to determine the mean age of onset of those cancers. This retrospective study includes proven carriers of a MMR mutation diagnosed either by the CHU of Liège or either by the CHC Saint-Joseph in Liège, Belgium. We noted a clear majority of MSH2 mutations (50 %) in the Lynch families recorded in Liège, which is different from the main literature. In our study population (106 subjects), 65 % of subjects were affected by at least one cancer. Prevalences for colorectal and endometrial cancers are, respectively, 50 % and 27.5 %. We found no difference in the mean age of onset of cancers compared to literature. We discuss the follow-up of Lynch patients and the interest of additional exams such as hysteroscopy and cystoscopy. © 2019 Revue Medicale de Liege. All rights reserved.
Disciplines :
Genetics & genetic processes
Author, co-author :
Lion, L.;  Epidémiologie et Economie de la santé, Liège Université, Belgium, Mme Laurine Lion, CHU Liège, Liège, 4000, Belgium
LECLERCQ, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de gastroentérologie, hépatologie, onco. digestive
Plomteux, O.;  Service de Gastroentérologie, CHC Saint-Joseph, Belgium
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique humaine
Language :
French
Title :
Etude des risques oncologiques associés au syndrome de Lynch en région liégeoise
Alternative titles :
[en] Study of cancer risks associated with Lynch syndrome in the Liège region
Publication date :
2019
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Revue Medicale de Liege
Volume :
74
Issue :
9
Pages :
479-483
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since 08 February 2020

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