Article (Scientific journals)
Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations.
Curigliano, Giuseppe; Lenihan, Daniel J.; Fradley, Michael G. et al.
2020In Annals of oncology : official journal of the European Society for Medical Oncology, 31 (2), p. 171-190
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Keywords :
Clinical Practice Guidelines; cardiac disease; cardiovascular toxicity; diagnosis; recommendations
Abstract :
[en] Cancer and cardiovascular (CV) disease are the most prevalent diseases in the developed world. Evidence increasingly shows that these conditions are interlinked through common risk factors, coincident in an ageing population, and are connected biologically through some deleterious effects of anticancer treatment on CV health. Anticancer therapies can cause a wide spectrum of short- and long-term cardiotoxic effects. An explosion of novel cancer therapies has revolutionised this field and dramatically altered cancer prognosis. Nevertheless, these new therapies have introduced unexpected CV complications beyond heart failure. Common CV toxicities related to cancer therapy are defined, along with suggested strategies for prevention, detection and treatment. This ESMO consensus article proposes to define CV toxicities related to cancer or its therapies and provide guidance regarding prevention, screening, monitoring and treatment of CV toxicity. The majority of anticancer therapies are associated with some CV toxicity, ranging from asymptomatic and transient to more clinically significant and long-lasting cardiac events. It is critical however, that concerns about potential CV damage resulting from anticancer therapies should be weighed against the potential benefits of cancer therapy, including benefits in overall survival. CV disease in patients with cancer is complex and treatment needs to be individualised. The scope of cardio-oncology is wide and includes prevention, detection, monitoring and treatment of CV toxicity related to cancer therapy, and also ensuring the safe development of future novel cancer treatments that minimise the impact on CV health. It is anticipated that the management strategies discussed herein will be suitable for the majority of patients. Nonetheless, the clinical judgment of physicians remains extremely important; hence, when using these best clinical practices to inform treatment options and decisions, practitioners should also consider the individual circumstances of their patients on a case-by-case basis.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Curigliano, Giuseppe
Lenihan, Daniel J.
Fradley, Michael G.
Ganatra, Sarju
Barac, A.
Blaes, A.
Herrmann, J.
Porter, C.
Lyon, A. R.
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Patel, A.
DeCara, J.
Mitchell, J.
Harrison, E.
Moslehi, J.
Witteles, R.
Calabro, M. G.
Orecchia, R.
de Azambuja, E.
Zamorano, J. L.
Krone, R.
Iakobishvili, Z.
Carver, J.
Armenian, S.
Ky, B.
Cardinale, D.
Cipolla, C. M.
Dent, S.
Jordan, K.
More authors (19 more) Less
Language :
English
Title :
Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations.
Publication date :
2020
Journal title :
Annals of oncology : official journal of the European Society for Medical Oncology
ISSN :
0923-7534
eISSN :
1569-8041
Volume :
31
Issue :
2
Pages :
171-190
Peer reviewed :
Peer reviewed
Commentary :
Copyright (c) 2019 European Society for Medical Oncology. Published by Elsevier Ltd. All rights reserved.
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since 03 February 2020

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