Article (Scientific journals)
Uremic toxin concentrations are related to residual kidney function in the pediatric hemodialysis population
Snauwaert, Evelien; Holvoet, Els; Van Biesen, Wim et al.
2019In Toxins, 11 (4)
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Keywords :
Child; Chronic kidney disease; End-stage kidney disease; Hemodialysis; Residual kidney function; Uremic toxins; Article
Abstract :
[en] Protein-bound uremic toxins (PBUTs) play a role in the multisystem disease that children on hemodialysis (HD) are facing, but little is known about their levels and protein binding (%PB). In this study, we evaluated the levels and %PB of six PBUTs cross-sectionally in a large pediatric HD cohort (n = 170) by comparing these with healthy and non-dialysis chronic kidney disease (CKD) stage 4-5 (n = 24) children. In parallel β2-microglobulin (β2M) and uric acid (UA) were evaluated. We then explored the impact of age and residual kidney function on uremic toxin levels and %PB using analysis of covariance and Spearman correlation coefficients (rs). We found higher levels of β2M, p-cresyl glucuronide (pCG), hippuric acid (HA), indole acetic acid (IAA), and indoxyl sulfate (IxS) in the HD compared to the CKD4-5 group. In the HD group, a positive correlation between age and pCG, HA, IxS, and pCS levels was shown. Residual urine volume was negatively correlated with levels of β2M, pCG, HA, IAA, IxS, and CMPF (rs -0.2 to -0.5). In addition, we found overall lower %PB of PBUTs in HD versus the CKD4-5 group, and showed an age-dependent increase in %PB of IAA, IxS, and pCS. Furhtermore, residual kidney function was overall positively correlated with %PB of PBUTs. In conclusion, residual kidney function and age contribute to PBUT levels and %PB in the pediatric HD population. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Disciplines :
Pediatrics
Urology & nephrology
Author, co-author :
Snauwaert, Evelien;  Ghent University Hospital, Ghent, 9000, Belgium
Holvoet, Els;  Ghent University Hospital, Ghent, 9000, Belgium
Van Biesen, Wim;  Ghent University Hospital, Ghent, 9000, Belgium
Raes, Ann;  Ghent University Hospital, Ghent, 9000, Belgium
Glorieux, Griet;  Ghent University Hospital, Ghent, 9000, Belgium
Vande Walle, Johan;  Ghent University Hospital, Ghent, 9000, Belgium
Roels, Sanne;  Department of Data Analysis, Faculty of Psychology and Pedagogy, Ghent University, Ghent, 9000, Belgium
Vanholder, Raymond;  Ghent University Hospital, Ghent, 9000, Belgium
Askiti, Varvara;  A&PKyriakouChildren’sHospital, Athens, 11527, Greece
Azukaitis, Karolis;  Clinic of Pediatrics, Faculty of Medicine, Vilnius University, Vilnius, 08406, Lithuania
Bayazit, Aysun;  Department of Pediatric Nephrology, Cukurova University, Adana, 01330, Turkey
Canpolat, Nur;  Department of Pediatric Nephrology, Istanbul University Cerrahpasa School of Medicine, Istanbul, 34096, Turkey
Fischbach, Michel;  Children’s Dialysis Center, Strasbourg, 67098, France
Godefroid, Nathalie;  Department of Pediatric Nephrology, Université Catholique Louvain, Brussels, 1200, Belgium
Krid, Saoussen;  Hôpital Necker-Enfants Malades, Paris, 75015, France
Litwin, Mieczyaw;  Department of Nephrology, Kidney Transplantation and Hypertension, Children’s Memorial Health Institute, Warsaw, 04-730, Poland
Obrycki, Lukasz;  Department of Nephrology, Kidney Transplantation and Hypertension, Children’s Memorial Health Institute, Warsaw, 04-730, Poland
Paglialonga, Fabio;  Pediatric Nephrology Dialysis and Transplant Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, 20122, Italy
Ranchin, Bruno;  Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, 69677, France
Samaille, Charlotte;  CHU Lille, Service de Néphrologie Pédiatrique, Lille, 59000, France
Schaefer, Franz;  Center for Pediatrics and Adolescent Medicine, Heidelberg, 69120, Germany
Schmitt, Claus Peter;  Center for Pediatrics and Adolescent Medicine, Heidelberg, 69120, Germany
Spasojevic, Brankica;  University Children’s Hospital, Belgrade and School of Medicine, University of Belgrade, Belgrade, 11000, Serbia
Stefanidis, Constantinos J.;  A&PKyriakouChildren’sHospital, Athens, 11527, Greece
Van Dyck, Maria;  Department of Pediatric Nephrology, Leuven University Hospital, Leuven, 3000, Belgium
Van Hoeck, Koen;  Department of Pediatric Nephrology, Antwerp University, Antwerp, 2650, Belgium
COLLARD, Laure ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Eloot, Sunny;  Ghent University Hospital, Ghent, 9000, Belgium
Shroff, Rukshana;  Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, United Kingdom
More authors (19 more) Less
Language :
English
Title :
Uremic toxin concentrations are related to residual kidney function in the pediatric hemodialysis population
Publication date :
24 April 2019
Journal title :
Toxins
eISSN :
2072-6651
Publisher :
MDPI AG
Volume :
11
Issue :
4
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Federal Agency for Science and Innovation: IWT, IWT-TBM 150195National Institute for Health ResearchBaxter InternationalAmgen
Available on ORBi :
since 28 January 2020

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