Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B

Hu, Xin; Xing, Yishen; Ren, Ling; Wang, Yahui; Li, Qian; Fu, Xing; Yang, Qiyuan; Xu, Lingyang; Willems, Luc; Li, Junya; Zhang, Lupei

doi:10.3390/ani9110859

Article (Scientific journals)

Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B

Hu, Xin; Xing, Yishen; Ren, Ling et al.

2019 • In Animals

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/244193

DOI
10.3390/ani9110859

PubMed
31652908

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Keywords :

bta-miR-24-3p; bovine; fetal skeletal muscle; proliferation; differentiation; ACVR1B

Abstract :

[en] MicroRNAs modulate a variety of cellular events, including skeletal muscle development, but the molecular basis of their functions in fetal bovine skeletal muscle development is poorly understood. In this study, we report that bta-miR-24-3p promotes the myogenic di erentiation of fetal bovine PDGFR - progenitor cells. The expression of bta-miR-24-3p increased during myogenic differentiation. Overexpression of bta-miR-24-3p significantly promoted myogenic di erentiation, but inhibited proliferation. A dual-luciferase assay identified ACVR1B as a direct target of bta-miR-24-3p. Similarly, knocking down ACVR1B by RNA interference also significantly inhibited proliferation and promoted the di erentiation of bovine PDGFR - progenitor cells. Thus, our study provides a mechanism in which bta-miR-24-3p regulates myogenesis by inhibiting ACVR1B expression.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Hu, Xin

Xing, Yishen

Ren, Ling

Wang, Yahui

Li, Qian

Fu, Xing

Yang, Qiyuan

Xu, Lingyang

Willems, Luc ; Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics

Li, Junya

Zhang, Lupei

Language :

English

Title :

Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B

Publication date :

24 October 2019

Journal title :

Animals

eISSN :

2076-2615

Publisher :

MDPI AG, Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

NSCF - National Natural Science Foundation of China [CN]
the Project of College Innovation Improvement under Beijing Municipality
the Cattle Breeding Innovative Research Team

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since 28 January 2020

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