Article (Scientific journals)
Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B
Hu, Xin; Xing, Yishen; Ren, Ling et al.
2019In Animals
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Keywords :
bta-miR-24-3p; bovine; fetal skeletal muscle; proliferation; differentiation; ACVR1B
Abstract :
[en] MicroRNAs modulate a variety of cellular events, including skeletal muscle development, but the molecular basis of their functions in fetal bovine skeletal muscle development is poorly understood. In this study, we report that bta-miR-24-3p promotes the myogenic di erentiation of fetal bovine PDGFR - progenitor cells. The expression of bta-miR-24-3p increased during myogenic differentiation. Overexpression of bta-miR-24-3p significantly promoted myogenic di erentiation, but inhibited proliferation. A dual-luciferase assay identified ACVR1B as a direct target of bta-miR-24-3p. Similarly, knocking down ACVR1B by RNA interference also significantly inhibited proliferation and promoted the di erentiation of bovine PDGFR - progenitor cells. Thus, our study provides a mechanism in which bta-miR-24-3p regulates myogenesis by inhibiting ACVR1B expression.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Hu, Xin
Xing, Yishen
Ren, Ling
Wang, Yahui
Li, Qian
Fu, Xing
Yang, Qiyuan
Xu, Lingyang
Willems, Luc  ;  Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Li, Junya
Zhang, Lupei
Language :
English
Title :
Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B
Publication date :
24 October 2019
Journal title :
Animals
eISSN :
2076-2615
Publisher :
MDPI AG, Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
NSCF - National Natural Science Foundation of China [CN]
the Project of College Innovation Improvement under Beijing Municipality
the Cattle Breeding Innovative Research Team
Available on ORBi :
since 28 January 2020

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