Article (Scientific journals)
Absence of correlation between follicular fluid volume and follicular granulocyte colony-stimulating factor, a predictor of embryo implantation and successful delivery.
NOEL, Laure; Donneau, Anne-Françoise; JOUAN, Caroline et al.
2020In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 36, p. 268-272
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Keywords :
ELISA; Granulocyte colony-stimulating factor; assisted reproductive technology; embryo selection; follicular fluid
Abstract :
[en] Follicular granulocyte colony-stimulating factor (G-CSF) is a documented marker of embryo implantation potential. The primary objective was to determine whether follicular G-CSF levels correlate with follicular fluid volume. The secondary objectives were to assess whether follicular G-CSF is associated with oocyte maturity at the time of harvest and with delivery rate after fresh or frozen embryo transfer. Thirty-two patients undergoing intracytoplasmic sperm injection (ICSI) cycles were recruited (Centre de Procreation Medicalement Assistee (CPMA), University of Liege, Belgium). A total of 211 follicular fluid (FF) samples were individually collected at the time of oocyte harvest. FF volume was recorded, and G-CSF concentration was assessed by ELISA. The embryos were individually cultured in vitro. Their implantation and live birth rates were recorded after fresh and frozen embryo transfers. The follicular fluid volume did not correlate with the follicular G-CSF concentration. There were no differences in follicular G-CSF levels between mature and immature oocytes. The probability of successful implantation and delivery was increased for embryos with FF containing a high G-CSF concentration. There was a trend toward lower follicular G-CSF levels in cases of miscarriage. Therefore, follicular fluid volume cannot be a substitute for follicular G-CSF as a marker of embryo implantation ability.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
NOEL, Laure ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Service de gynécologie-obstétrique (CHR)
Donneau, Anne-Françoise ;  Université de Liège - ULiège > Département des sciences de la santé publique > Biostatistique
JOUAN, Caroline ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Centre de procréation médicalement assistée (CPMA)
SCHOENEN, Sophie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Service de gynécologie-obstétrique
Ledee, Nathalie
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Nisolle, Michelle ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Munaut, Carine  ;  Université de Liège - ULiège > Cancer-Tumours and development biology
Language :
English
Title :
Absence of correlation between follicular fluid volume and follicular granulocyte colony-stimulating factor, a predictor of embryo implantation and successful delivery.
Publication date :
2020
Journal title :
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
ISSN :
0951-3590
eISSN :
1473-0766
Volume :
36
Pages :
268-272
Peer reviewed :
Peer reviewed
Available on ORBi :
since 20 January 2020

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