Alteration in bile acids profile in Large White pigs during chronic heat exposure.

[en] Bile acids (BAs) are critical for cholesterol homeostasis and new roles in metabolism and endocrinology have been demonstrated recently. It remains unknown whether BA metabolism can be affected by heat stress (HS). The objective of this study was to describe the shifts in serum, hepatic and intestinal BA profiles induced by chronic HS. Twenty-seven Large White pigs weighing 40.8+/-2.7kg were assigned to one of the three treatments: a control group (CON, 23 degrees C), a HS group (33 degrees C), or a pair-fed group (PF, 23 degrees C and fed the same amount as HS group) for 21d. The concentrations of taurine-conjugated BAs (TUDCA and THDCA in serum and TCDCA, TUDCA, THDCA and THCA in liver) were decreased in HS and PF pigs. However, in HS pigs, a reduction in taurine-conjugated BAs (TCBA) correlated with decreased liver genes expression of BA synthesis, conjugation and uptake transport. BA regulated-genes (FXR, TGR5 and FGFR4) in HS pigs and TGR5, FGFR4 and KLbeta in PF pigs were down-regulated in liver. In ileum, total BAs and glycoursodeoxycholic acid concentrations were higher in HS pigs than other groups and PF group, respectively (P<0.05). TCBA (P=0.01) and tauroursodeoxycholic acid (P<0.01) were decreased in PF group. BA transporters (OSTalpha and MRP3) were up-regulated in HS pigs compared with CON and PF pigs, respectively (P<0.01). In cecum, ursodeoxycholic acid was higher in HS (P=0.02) group than CON group. The expression of apical sodium-coupled bile acid transporter (P=0.04) was lower in HS pigs than CON pigs, while OSTbeta (P<0.01) was greater in HS group than PF group. These results suggest that chronic HS suppressed liver activity of synthesis and uptake of TCBA, at least in part, which was independent of reduced feed intake.

Disciplines :

Agriculture & agronomy

Author, co-author :

Fang, Wei

Wen, Xiaobin

Meng, Qingshi

Wu, Weida

Everaert, Nadia ; Université de Liège - ULiège > Département GxABT > Ingénierie des productions animales et nutrition

Xie, Jingjing

Zhang, Hongfu

Language :

English

Title :

Alteration in bile acids profile in Large White pigs during chronic heat exposure.

Publication date :

2019

Journal title :

Journal of Thermal Biology

ISSN :

0306-4565

Publisher :

Elsevier, United Kingdom

Volume :

Pages :

375-383

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 17 January 2020

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