Reference : Chromametric assessment of drug skin tolerance: A comparative study between Africans...
Scientific journals : Article
Human health sciences : Dermatology
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/242981
Chromametric assessment of drug skin tolerance: A comparative study between Africans and Caucasians skins
English
Sounouvou, Axel Gérald Hope Tognidé mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
Lechanteur, Anna mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Quetin-Leclercq, Joëlle mailto [Université Catholique de Louvain - UCL > Louvain Drug Research Institute (LDRI) > Pharmacognosy Research Group (GNOS) > >]
Piel, Géraldine mailto [Université de Liège - ULiège > Département de pharmacie > Développement de nanomédicaments >]
Donneau, Anne-Françoise mailto [Université de Liège - ULiège > Département des sciences de la santé publique > Biostatistique >]
Gbaguidi, Fernand mailto [Université d'Abomey-Calavi - UAC > Faculté des Sciences de la Santé, UFR Pharmacie > Medicinal Organic Chemistry Laboratory (MOCL) > >]
Evrard, Brigitte mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
29-Nov-2019
Skin Research and Technology
Blackwell
Yes (verified by ORBi)
International
0909-752X
1600-0846
Oxford
United Kingdom
[en] dark skin ; drug development ; in vivo tolerance study ; Tristimulus chromameter
[en] Background/Aims: During dermatological forms development, one of the simplest non-invasive techniques used to evaluate cutaneous tolerance of formulations is to monitor the color changes using a tristimulus chromameter. Most published tolerance studies involving chromametric measurements are performed on Caucasian subjects. However, in the context of drug formulation for African-type populations, it is not always relevant to transpose tolerance results obtained on Caucasians populations to African-type ones due to histological ethnic differences of the skin. The goal of this work was to assess whether tristimulus chromameter can be used to highlight color variations following the application of dermatological topics on black skin in order to validate skin tolerance studies made on African-type subjects. Materials and Methods: After application of two commercial creams with opposite side effects (skin irritation and skin blanching) in both Africans and Caucasians populations, color variations were evaluated using a tristimulus chromameter in L*a*b* color system and compared between both populations. L* indicating color brightness, a* represents green and red directions and b* represents blue and yellow directions. Results: While skin irritation resulted in a significant increase of a* parameter in both studied populations, the skin blanching resulted in a decrease of a* associated with an increase of L*. Conclusion: We established that tristimulus chromameter can be used to achieve in vivo skin tolerance study of dermatologic formulations in Africans despite their dark skin even though it appeared less sensitive. This study can speed up the development of dermatological forms dedicated to Africans and/or Caucasians subjects.
Center for Interdisciplinary Research on Medicines
ARES. CCD - Académie de Recherche et d'Enseignement Supérieur. Coopération au Développement
VALTRAMED
Researchers ; Professionals ; Students ; General public ; Others
http://hdl.handle.net/2268/242981
10.1111/srt.12804

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