[en] Poly(L-lactic acid) (PLLA) fibers were impregnated with the anti-inflammatory drug ketoprofen by supercritical CO2 (scCO2) assisted impregnation process, to develop drug-eluting absorbable sutures. This work indicates the possibility to tune not only the drug loading but also the release profile of ketoprofen from PLLA by modifying the impregnation (temperature and pressure) and depressurization (temperature and rate) conditions. Different PLLA sutures that release ketoprofen during 3 days up to 3 months were obtained. The release was shown to be governed by two parameters: the degradation rate of PLLA, that increases with the drug impregnation, and the sutures free volume, that was created due to scCO2 sorbed and was partially conserved during depressurization. The degradation rate and the tensile strength loss of the suture are accelerated by ketoprofen since it catalyzes PLLA acid hydrolysis.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM) Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Champeau, Mathilde; Federal University of ABC, Santo André, Center of Engineering, Modeling and Applied Social Sciences, Brazil
Trindade Coutinho, Isabela; Federal University of ABC, Santo André, Center of Engineering, Modeling and Applied Social Sciences, Brazil
Thomassin, Jean-Michel ; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit, Center for Education and Research on Macromolecules (CERM), Belgium
Tassaing, Thierry; University of Bordeaux, CNRS, Institute of Molecular Sciences, Talence, France
Jérôme, Christine ; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit, Center for Education and Research on Macromolecules (CERM), Belgium
Language :
English
Title :
Tuning the release profile of ketoprofen from poly(L-lactic acid) suture using supercritical CO2 impregnation process
Publication date :
February 2020
Journal title :
Journal of Drug Delivery Science and Technology
ISSN :
1773-2247
eISSN :
2588-8943
Publisher :
Éditions de Santé, France
Volume :
55
Pages :
101468
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BELSPO - Politique scientifique fédérale F.R.S.-FNRS - Fonds de la Recherche Scientifique CAPES - Coordenação de Aperfeicoamento de Pessoal de Nível Superior FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
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