Influence of bone mineral density in circulating adipokines among postmenopausal Arab women

[en] Osteoporosis and osteopenia has a significant link with substantial fracture risk. Epidemiological data revealed a protective role of adipose tissue on bone biology in postmenopausal osteoporosis. The current study assessed the associations between select adipokines and bone mineral density (BMD) in postmenopausal women. A total of 175 Saudi postmenopausal women were selected and categorized based on their BMD (normal & low-BMD). Circulating levels of select adipokines (adiponectin, resistin, leptin, and adipsin), insulin, 25(OH)D and RANKl were determined using commercially available assay kits. BMD was measured by dual-energy X-ray absorptiometry (DXA). Overall and among low-BMD subjects, adiponectin consistently showed a significant inverse association with BMD (overall -0.34, p < 0.01; low BMD group -0.34, p < 0.01). In multiple regression, adiponectin (-0.29 ± 0.06, p < 0.00) and resistin (-0.08 ± 0.04, p < 0.05) were inversely significant with BMD overall, but after stratification the significance was lost for resistin (-0.05 ± 0.04, p < 0.224) whereas adiponectin remained (-0.22 ± 0.07, p < 0.02) in low-BMD subjects. Adipsin, leptin and lipocalin-2 showed no significant associations. Findings of the present study revealed that only adiponectin showed a significantly strong inverse association with low BMD, suggesting that insulin sensitivity may influence bone health in Arab postmenopausal women.

Disciplines :

Public health, health care sciences & services

Author, co-author :

Ansari, Mohammed Ghouse Ahmed

Hussain, Syed Danish

Wani, Kaiser Ahmed

Yakout, Sobhy M.

Al-Disi, Dara

Alokail, Majed S.

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Al-Daghri, Nasser M.

Language :

English

Title :

Influence of bone mineral density in circulating adipokines among postmenopausal Arab women

Publication date :

January 2020

Journal title :

Saudi Journal of Biological Sciences

ISSN :

1319-562X

Publisher :

Elsevier

Volume :

Issue :

Pages :

374-379

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 January 2020

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