Article (Scientific journals)
Influence of bone mineral density in circulating adipokines among postmenopausal Arab women
Ansari, Mohammed Ghouse Ahmed; Hussain, Syed Danish; Wani, Kaiser Ahmed et al.
2020In Saudi Journal of Biological Sciences, 27 (1), p. 374-379
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Keywords :
Adipocytokines; Osteoporosis/osteopenia; Saudi postmenopausal women
Abstract :
[en] Osteoporosis and osteopenia has a significant link with substantial fracture risk. Epidemiological data revealed a protective role of adipose tissue on bone biology in postmenopausal osteoporosis. The current study assessed the associations between select adipokines and bone mineral density (BMD) in postmenopausal women. A total of 175 Saudi postmenopausal women were selected and categorized based on their BMD (normal & low-BMD). Circulating levels of select adipokines (adiponectin, resistin, leptin, and adipsin), insulin, 25(OH)D and RANKl were determined using commercially available assay kits. BMD was measured by dual-energy X-ray absorptiometry (DXA). Overall and among low-BMD subjects, adiponectin consistently showed a significant inverse association with BMD (overall -0.34, p < 0.01; low BMD group -0.34, p < 0.01). In multiple regression, adiponectin (-0.29 ± 0.06, p < 0.00) and resistin (-0.08 ± 0.04, p < 0.05) were inversely significant with BMD overall, but after stratification the significance was lost for resistin (-0.05 ± 0.04, p < 0.224) whereas adiponectin remained (-0.22 ± 0.07, p < 0.02) in low-BMD subjects. Adipsin, leptin and lipocalin-2 showed no significant associations. Findings of the present study revealed that only adiponectin showed a significantly strong inverse association with low BMD, suggesting that insulin sensitivity may influence bone health in Arab postmenopausal women.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Ansari, Mohammed Ghouse Ahmed
Hussain, Syed Danish
Wani, Kaiser Ahmed
Yakout, Sobhy M.
Al-Disi, Dara
Alokail, Majed S.
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Al-Daghri, Nasser M.
Language :
English
Title :
Influence of bone mineral density in circulating adipokines among postmenopausal Arab women
Publication date :
January 2020
Journal title :
Saudi Journal of Biological Sciences
ISSN :
1319-562X
Publisher :
Elsevier
Volume :
27
Issue :
1
Pages :
374-379
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 January 2020

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