Salivary cortisol profiles in patients remitted from recurrent depression: One-year follow-up of a mindfulness-based cognitive therapy trial

Gex-Fabry, Marianne; Jermann, Françoise; Kosel, Markus; Rossier, Michel F.; Van der Linden, Martial; Bertschy, Gilles; Bondolfi, Guido; Aubry, Jean-Marie

doi:10.1016/j.jpsychires.2011.09.011

Article (Scientific journals)

Salivary cortisol profiles in patients remitted from recurrent depression: One-year follow-up of a mindfulness-based cognitive therapy trial

Gex-Fabry, Marianne; Jermann, Françoise; Kosel, Markus et al.

2012 • In Journal of Psychiatric Research, 46 (1), p. 80-86

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/242799

DOI
10.1016/j.jpsychires.2011.09.011

PubMed
21982583

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Keywords :

Cortisol awakening response; Depression; Diurnal cortisol profile; Mindfulness-based cognitive therapy

Abstract :

[en] Few studies have examined changes of diurnal cortisol profiles prospectively, in relation to non-pharmacological interventions such as mindfulness-based cognitive therapy (MBCT). Fifty-six patients remitted from recurrent depression (≥3 episodes) were included in an 8-week randomized controlled trial comparing MBCT plus treatment as usual (TAU) with TAU for depression relapse prophylaxis. Saliva samples (0, 15, 30, 45, 60 min post-awakening, 3 PM, 8 PM) were collected on six occasions (pre- and post-intervention, 3-, 6-, 9-, 12-month follow-up). Cortisol awakening response (CAR), average day exposure (AUCday) and diurnal slope were analyzed with mixed effects models (248 profiles, 1-6 per patient). MBCT (n = 28) and TAU groups (n = 28) did not significantly differ with respect to baseline variables. Intra-individual variability exceeded inter-individual variability for the CAR (62.2% vs. 32.5%), AUCday (30.9% vs. 23.6%) and diurnal slope (51.0% vs. 34.2%). No time, group and time by group effect was observed for the CAR and diurnal slope. A significant time effect (p = 0.003) was detected for AUCday, which was explained by seasonal variations (p = 0.012). Later wake-up was associated with lower CAR (-11.7% per 1-hour later awakening, p < 0.001) and lower AUCday (-4.5%, p = 0.014). Longer depression history was associated with dampened CAR (-15.2% per 10-year longer illness, p = 0.003) and lower AUCday (-8.8%, p = 0.011). Unchanged cortisol secretion patterns following participation in MBCT should be interpreted with regard to large unexplained variability, similar relapse rates in both groups and study limitations. Further research is needed to address the scar hypothesis of diminished HPA activity with a longer, chronic course of depression. © 2011 Elsevier Ltd.

Disciplines :

Neurosciences & behavior

Author, co-author :

Gex-Fabry, Marianne; Department of Mental Health and Psychiatry, Geneva University Hospitals, 2 chemin du Petit-Bel-Air, CH-1225 Chêne-Bourg, Geneva, Switzerland

Jermann, Françoise; Department of Mental Health and Psychiatry, Geneva University Hospitals, 2 chemin du Petit-Bel-Air, CH-1225 Chêne-Bourg, Geneva, Switzerland

Kosel, Markus; Department of Mental Health and Psychiatry, Geneva University Hospitals, 2 chemin du Petit-Bel-Air, CH-1225 Chêne-Bourg, Geneva, Switzerland

Rossier, Michel F.; Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland

Van der Linden, Martial ; Université de Liège - ULiège > Département de Psychologie > Département de Psychologie

Bertschy, Gilles; INSERM Unit 666 and University of Strasbourg, Department of Psychiatry and Mental Health, University Hospital of Strasbourg, Strasbourg, France

Bondolfi, Guido; Department of Mental Health and Psychiatry, Geneva University Hospitals, 2 chemin du Petit-Bel-Air, CH-1225 Chêne-Bourg, Geneva, Switzerland

Aubry, Jean-Marie ; Université de Liège - ULiège > Département de mathématique > Analyse - Analyse fonctionnelle - Ondelettes

Language :

English

Title :

Salivary cortisol profiles in patients remitted from recurrent depression: One-year follow-up of a mindfulness-based cognitive therapy trial

Publication date :

2012

Journal title :

Journal of Psychiatric Research

ISSN :

0022-3956

eISSN :

1879-1379

Publisher :

Elsevier, United Kingdom

Volume :

Issue :

Pages :

80-86

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

SNF - Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung

Available on ORBi :

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