A multidimensional approach to impulsivity changes in mild Alzheimer's disease and control participants: Cognitive correlates

Rochat, Lucien; Billieux, Joël; Juillerat Van der Linden, Anne-Claude; Annoni, Jean-Marie; Zekry, Dina; Gold, Gabriel; Van der Linden, Martial

doi:10.1016/j.cortex.2011.08.004

Article (Scientific journals)

A multidimensional approach to impulsivity changes in mild Alzheimer's disease and control participants: Cognitive correlates

Rochat, Lucien; Billieux, Joël; Juillerat Van der Linden, Anne-Claude et al.

2013 • In Cortex: A Journal Devoted to the Study of the Nervous System and Behavior, 49 (1), p. 90-100

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/242657

DOI
10.1016/j.cortex.2011.08.004

PubMed
21943808

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

1-s2.0-S0010945211002371-main.pdf

Publisher postprint (363.78 kB)

Request a copy

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

Alzheimer; Executive functions; Impulsivity; Inhibition; UPPS Impulsive Behavior scale; Alzheimer disease

Abstract :

[en] Introduction: Impulsive behaviors are frequently described in brain-damaged patients, including patients with Alzheimer's disease (AD). However, few studies have examined impulsivity changes and associated cognitive impairments in AD and healthy controls. Consequently, the first aim of this study was to compare patients with mild AD and matched controls on four dimensions of impulsivity (urgency, lack of premeditation, lack of perseverance, and sensation seeking) recently highlighted in the literature. The second objective was to examine the association between impulsivity changes and cognitive performances on executive/attentional tasks in mild AD and healthy controls. Methods: Thirty patients with mild AD and 30 matched controls were administered a battery of tests that assessed executive and attention processes. In addition, informants of each patient and control completed a short questionnaire designed to assess the changes on the four dimensions of impulsivity (Rochat et al., 2008). Results: Patients with mild AD had higher scores than controls on lack of premeditation and lack of perseverance dimensions of impulsivity, whereas the two groups did not differ on urgency and sensation seeking. Furthermore, patients showed significant decreased performances on measures of inhibition of prepotent responses, set-shifting, and working memory, as well as higher variability of reaction times (RTs) than matched controls. Regression analyses computed on the whole sample emphasized that difficulties in inhibition of prepotent responses significantly predicted higher lack of premeditation, and larger variability of RTs and set-shifting difficulties significantly predicted higher lack of perseverance, even when global cognitive functioning, general processing speed, working memory, and age were controlled for. Urgency and sensation seeking were not associated with any variables. Conclusions: These results provide valuable insight into the nature of brain systems and cognitive processes underlying impulsive behaviors. In addition, they open up interesting prospects for better comprehension of behavioral and psychological symptoms of AD. © 2011 Elsevier Ltd.

Disciplines :

Neurosciences & behavior

Author, co-author :

Rochat, Lucien; Cognitive Psychopathology and Neuropsychology Unit, University of Geneva, Geneva, Switzerland, Swiss Centre for Affective Sciences, University of Geneva, Geneva, Switzerland

Billieux, Joël; Cognitive Psychopathology and Neuropsychology Unit, University of Geneva, Geneva, Switzerland, Swiss Centre for Affective Sciences, University of Geneva, Geneva, Switzerland

Juillerat Van der Linden, Anne-Claude; Department of Rehabilitation and Geriatrics, Geneva University Hospital, Switzerland

Annoni, Jean-Marie; Neuropsychology Unit, Geneva University Hospital, Geneva, Switzerland, Neurology Unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland

Zekry, Dina; Department of Rehabilitation and Geriatrics, Geneva University Hospital, Switzerland

Gold, Gabriel; Department of Rehabilitation and Geriatrics, Geneva University Hospital, Switzerland

Van der Linden, Martial ; Université de Liège - ULiège > Département de Psychologie > Département de Psychologie

Language :

English

Title :

A multidimensional approach to impulsivity changes in mild Alzheimer's disease and control participants: Cognitive correlates

Publication date :

2013

Journal title :

Cortex: A Journal Devoted to the Study of the Nervous System and Behavior

ISSN :

0010-9452

eISSN :

1973-8102

Publisher :

Masson SpA

Volume :

Issue :

Pages :

90-100

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 03 January 2020

Statistics

Number of views

48 (2 by ULiège)

Number of downloads

3 (3 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Aalten P., Verhey F.R., Boziki M., Bullock R., Byrne E.J., Camus V., et al. Neuropsychiatric syndromes in dementia. Results from the European Alzheimer disease consortium: Part I. Dementia and Geriatric Cognitive Disorders 2007, 24(6):457-463.
Allison P.D. Logistic Regression Using the SAS System: Theory and Application 1999, SAS Institute Inc., Cary.
Amieva H., Phillips L.H., Della Sala S., Henry J.D. Inhibitory functioning in Alzheimer's disease. Brain 2004, 127(5):949-964.
Anestis M.D., Selby E.A., Joiner T.E. The role of urgency in maladaptive behaviors. Behaviour Research and Therapy 2007, 45(12):3018-3029.
Bechara A., Van der Linden M. Decision-making and impulse control after frontal lobe injuries. Current Opinion in Neurology 2005, 18(6):734-739.
Belleville S., Bherer L., Lepage E., Chertkow H., Gauthier S. Task switching capacities in persons with Alzheimer's disease and mild cognitive impairment. Neuropsychologia 2008, 46(8):2225-2233.
Bellgrove M.A., Hawi Z., Kirley A., Gill M., Robertson I.H. Dissecting the attention deficit hyperactivity disorder (ADHD) phenotype: Sustained attention, response variability and spatial attentional asymmetries in relation to dopamine transporter (DAT1) genotype. Neuropsychologia 2005, 43(13):1847-1857.
Billieux J., Van der Linden M., Ceschi G. Which dimensions of impulsivity are related to cigarette craving?. Addictive Behaviors 2007, 32(6):1189-1199.
Billieux J., Rochat L., Rebetez M.M.L., Van der Linden M. Are all facets of impulsivity related to self-reported compulsive buying behavior?. Personality and Individual Differences 2008, 44(6):1432-1442.
Billieux J., Rochat L., Van der Linden M. Une approche cognitive, affective et motivationnelle de l'impulsivité. Traité de Psychopathologie Cognitive, Tome I 2008, 137-152. Solal, Marseille. M. Van der Linden, G. Ceschi (Eds.).
Billieux J., Gay P., Rochat L., Van der Linden M. The role of urgency and its underlying psychological mechanisms in problematic behaviours. Behaviour Research and Therapy 2010, 48(11):1085-1096.
Carstensen L.L., Turan B., Scheibe S., Ram N., Ersner-Hershfield H., Samanez-Larkin G.R., et al. Emotional experience improves with age: Evidence based on over 10 years of experience sampling. Psychology and Aging 2011, 26(1):21-33.
Claes L., Vandereycken W., Vertommen H. Impulsivity-related traits in eating disorders patients. Personality and Individual Differences 2005, 39(4):739-749.
Colette F., Van der Linden M. Executive functions in Alzheimer's disease. The Cognitive Neuropsychology of Alzheimer's Disease 2004, 103-120. Oxford University Press, Oxford. 2nd ed. R.G. Morris, B.T. Becker (Eds.).
Collette F., Van der Linden M., Salmon E. Executive dysfunction in Alzheimer's disease. Cortex 1999, 35(1):57-72.
Collette F., Schmidt C., Scherrer C., Adam S., Salmon E. Specificity of inhibitory deficits in normal aging and Alzheimer's disease. Neurobiology of Aging 2009, 30(6):875-889.
Costa P.T., McCrae R.R. Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI): Professional Manual 1992, Psychological Assessment Resources, Odessa.
Cousineau D., Brown S., Heathcote A. Fitting distributions using maximum likelihood: Methods and packages. Behavior Research Methods, Instruments, & Computers 2004, 36(4):742-756.
Cummings J.L., Mega M., Gray K., Rosenberg-Thompson S., Carusi D.A., Gornbein J. The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology 1994, 44(12):2308-2314.
Cyders M.A., Smith G.T. Emotion-based dispositions to rash action: Positive and negative urgency. Psychological Bulletin 2008, 134(6):807-828.
Delazer M., Sinz H., Zamarian L., Benke T. Decision-making with explicit and stable rules in mild Alzheimer's disease. Neuropsychologia 2007, 45(8):1632-1641.
Duberstein P.R., Chapman B.P., Tindle H.A., Sink K.M., Bamonti P., Robbins J., et al. Personality and risk for Alzheimer's disease in adults 72 years of age and older: A 6-year follow-up. Psychology and Aging 2011, 26(2):351-362.
Duchek J.M., Balota D.A., Storandt M., Larsen R. The power of personality in discriminating between healthy aging and early-stage Alzheimer's disease. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences 2007, 62(6):353-361.
Duchek J.M., Balota D.A., Tse C., Holtzman D.M., Fagan A.M., Goate A.M. The utility of intraindividual variability in selective attention tasks as an early marker for Alzheimer's disease. Neuropsychology 2009, 23(6):746-758.
Evans J.S.B.T. In two minds: Dual-process accounts of reasoning. Trends in Cognitive Sciences 2003, 7(10):454-459.
Evenden J.L. Varieties of impulsivity. Psychopharmacology 1999, 146(4):348-361.
Faust M.E., Balota D.A., Spieler D.H., Ferraro F.R. Individual differences in information-processing rate and amount: Implications for group differences in response latency. Psychological Bulletin 1999, 125(6):777-799.
Folstein M.F., Folstein S.E., McHugh P.R. Mini Mental State: A practical method for grading the cognitive state of outpatients for the clinician. The Journal of Psychiatric Research 1975, 12:189-198.
Freund A.M. Age-differential motivational consequences of optimization versus compensation focus in younger and older adults. Psychology and Aging 2006, 21(2):240-252.
Friedman N.P., Miyake A. The relations among inhibition and interference control functions: A latent-variable analysis. Journal of Experimental Psychology: General 2004, 133(1):101-135.
Gay P., Rochat L., Billieux J., d'Acremont M., Van der Linden M. Heterogeneous inhibition processes involved in different facets of self-reported impulsivity: Evidence from a community sample. Acta Psychologica 2008, 129(3):332-339.
Gay P., Courvoisier D.S., Billieux J., Rochat L., Schmidt R.E., Van der Linden M. Can the distinction between intentional and unintentional interference control help differentiate varieties of impulsivity?. Journal of Research in Personality 2010, 44(1):46-52.
Hollingworth P., Hamshere M.L., Moskvina V., Dowzell K., Moore P.J., Foy C., et al. Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease. Journal of the American Geriatrics Society 2006, 54(9):1348-1354.
Holmes J.A., Johnson J.L., Roedel A.L. Impulsivity in adult neurobehavioral disorders. The Impulsive Client: Theory, Research, Treatment 1993, 309-321. American Psychological Association, Washington. W.G. McCown, J.L. Johnson, M.B. Shure (Eds.).
Hughes C.P., Berg L., Danziger W.L., Coben L., Martin R.L. A new clinical scale for the staging of dementia. British Journal of Psychiatry 1982, 140:566-572.
Johnson K.A., Kelly S.P., Bellgrove M.A., Barry E., Cox M., Gill M., et al. Response variability in attention deficit hyperactivity disorder: Evidence for neuropsychological heterogeneity. Neuropsychologia 2007, 45(4):630-638.
Lonie J.A., Tierney K.M., Herrmann L.L., Donaghey C., O'Carroll R.E., Lee A., et al. Dual task performance in early Alzheimer's disease, amnestic mild cognitive impairment and depression. Psychological Medicine 2009, 39(1):23-31.
Mattis M. Mental status examination for organic mental syndrome in the elderly patient. Geriatric Psychiatry: A Handbook for Psychiatrists and Primary Care Physicians 1976, 77-121. Grune and Stratton, New York. L. Bellack (Ed.).
McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34(7):934-939.
Miller J., Flory K., Lynam D.R., Leukefeld C. A test of the four-factor model of impulsivity-related traits. Personality and Individual Differences 2003, 34(8):1403-1418.
Noël X., Bechara A., Dan B., Hanak C., Verbanck P. Response inhibition deficit is involved in poor decision making under risk in nonamnesic individuals with alcoholism. Neuropsychology 2007, 21(6):778-786.
Ochsner K.N., Gross J.J. The cognitive control of emotion. Trends in Cognitive Sciences 2005, 9(5):242-249.
O'Connell R.G., Dockree P.M., Bellgrove M.A., Turin A., Ward S., Foxe J.J., et al. Two types of action error: Electrophysiological evidence for separable inhibitory and sustained attention neural mechanisms producing error on go/no-go tasks. Journal of Cognitive Neuroscience 2009, 21(1):93-104.
Park D.C., Reuter-Lorenz P. The adaptive brain: Aging and neurocognitive scaffolding. Annual Review of Psychology 2009, 60(1):173-196.
Perales J.C., Verdejo-García A., Moya M., Lozano O., Pérez-García M. Bright and dark sides of impulsivity: Performance of women with high and low trait impulsivity on neuropsychological tasks. Journal of Clinical and Experimental Neuropsychology 2009, 31(8):927-944.
Phillips L.H., Andrés P. The cognitive neuroscience of aging: New findings on compensation and connectivity. Cortex 2010, 46(4):421-424.
Reitan R.M., Wolfson D. The Halstead-Reitan Neuropsychological Test Battery 1985, Neuropsychology Press, Tucson.
Robertson I.H., Manly T., Andrade J., Baddeley B.T., Yiend J. 'Oops!': Performance correlates of everyday attentional failures in traumatic brain injured and normal subjects. Neuropsychologia 1997, 35(6):747-758.
Rochat L., Delbeuck X., Billieux J., d'Acremont M., Juillerat Van der Linden A.C., Van der Linden M. Assessing impulsivity changes in Alzheimer disease. Alzheimer Disease and Associated Disorders 2008, 22(3):278-283.
Rochat L., Beni C., Billieux J., Azouvi P., Annoni J.M., Van der Linden M. Assessment of impulsivity after moderate to severe traumatic brain injury. Neuropsychological Rehabilitation 2010, 20(5):778-797.
Sanchez-Cubillo I., Perianez J.A., Adrover-Roig D., Rodriguez-Sanchez J.M., Rios-Lago M., Tirapu J., et al. Construct validity of the Trail Making Test: Role of task-switching, working memory, inhibition/interference control, and visuomotor abilities. Journal of the International Neuropsychological Society 2009, 15(3):438-450.
Scheibe S., Carstensen L.L. Emotional aging: Recent findings and future trends. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences 2010, 65B(2):135-144.
Schulz K.P., Fan J., Magidina O., Marks D.J., Hahn B., Halperin J.M. Does the emotional go/no-go task really measure behavioral inhibition? Convergence with measures on a non-emotional analog. Archives of Clinical Neuropsychology 2007, 22(2):151-160.
Smith G.T., Fischer S., Cyders M.A., Annus A.M., Spillane N.S., McCarthy D.M. On the validity and utility of discriminating among impulsivity-like traits. Assessment 2007, 14(2):155-170.
Spalletta G., Musicco M., Padovani A., Rozzini L., Perri R., Fadda L., et al. Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease. American Journal of Geriatric Psychiatry 2010, 18(11):1026-1035.
Stokholm J., Vogel A., Gade A., Waldemar G. Heterogeneity in executive impairment in patients with very mild Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 2006, 22(1):54-59.
Stuss D.T., Murphy K.J., Binns M.A., Alexander M.P. Staying on the job: The frontal lobes control individual performance variability. Brain 2003, 126(Pt 11):2363-2380.
Tse C.S., Balota D.A., Yap M.J., Duchek J.M., McCabe D.P. Effects of healthy aging and early stage dementia of the Alzheimer's type on components of response time distributions in three attention tasks. Neuropsychology 2010, 24(3):300-315.
Unsworth N., Redick T.S., Lakey C.E., Young D.L. Lapses in sustained attention and their relation to executive control and fluid abilities: An individual differences investigation. Intelligence 2010, 38(1):111-122.
Van der Linden M., Rochat L., Billieux J. Troubles du comportement socio-émotionnel et impulsivité: Une approche cognitive et neuropsychologique. Comportement et Lésions Cérébrales 2006, 53-58. Frison-Roche, Paris. P. Azouvi, J. Mazaux, P. Pradat-Diehl (Eds.).
Verbruggen F., De Houwer J. Do emotional stimuli interfere with response inhibition? Evidence from the stop signal paradigm. Cognition and Emotion 2007, 21(2):391-403.
Verdejo-García A., Bechara A., Recknor E.C., Pérez-García M. Negative emotion-driven impulsivity predicts substance dependence problems. Drug and Alcohol Dependence 2007, 91(2-3):213-219.
Walters G.D. Dementia: Continuum or distinct entity?. Psychology and Aging 2010, 25(3):534-544.
Wechsler D. Wechsler Adult Intelligence Scale 1997, The Psychological Corporation, San Antonio. 3rd ed.
West R., Murphy K.J., Armilio M.L., Craik F.I.M., Stuss D.T. Lapses of intention and performance variability reveal age-related increases in fluctuations of executive control. Brain and Cognition 2002, 49(3):402-419.
Whiteside S.P., Lynam D.R. The Five Factor Model and impulsivity: Using a structural model of personality to understand impulsivity. Personality and Individual Differences 2001, 30(4):669-689.
Whiteside S.P., Lynam D.R. Understanding the role of impulsivity and externalizing psychopathology in alcohol abuse: Application of the UPPS impulsive behavior scale. Experimental and Clinical Psychopharmacology 2003, 11(3):210-217.
Whiteside S.P., Lynam D.R., Miller J., Reynolds B. Validation of the UPPS impulsive behaviour scale: A four-factor model of impulsivity. European Journal of Personality 2005, 19(7):559-574.
Wilson R.S., Schneider J.A., Arnold S.E., Bienias J.L., Bennett D.A. Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment. Archives of General Psychiatry 2007, 64(10):1204-1212.
Wright C.I., Dickerson B.C., Feczko E., Negeira A., Williams D. A functional magnetic resonance imaging study of amygdala responses to human faces in aging and mild Alzheimer's disease. Biological Psychiatry 2007, 62(12):1388-1395.
Zamarian L., Sinz H., Bonatti E., Gamboz N., Delazer M. Normal aging affects decisions under ambiguity, but not decisions under risk. Neuropsychology 2008, 22(5):645-657.
Zermatten A., Van der Linden M. Impulsivity in non-clinical persons with obsessive-compulsive symptoms. Personality and Individual Differences 2008, 44(8):1824-1830.
Zermatten A., Van der Linden M., d'Acremont M., Jermann F., Bechara A. Impulsivity and decision making. Journal of Nervous and Mental Disease 2005, 193(10):647-650.