hantavirus infection; transmission of the virus; hantavirus enzootic cycle
Abstract :
[en] Populations of bank voles (Clethrionomys glareolus) were monitored during a 4-year study in southern Belgium to assess the influence of agonistic behavior, reproductive status, mobility, and distribution of the rodents on the dynamics of Puumala virus (abbreviation: PUUV; genus: Hantavirus) infection. Concordance was high between data from serologic testing and results of viral RNA detection. Wounds resulting from biting or scratching were observed mainly in adult rodents. Hantavirus infection in adults was associated with wounds in the fall, i.e., at the end of the breeding season, but not in spring. In addition, sexually active animals were significantly more often wounded and positive for infection. Hantavirus infection was associated with higher mobility in juvenile and subadult males. Seroconversions observed 6 months apart also occurred more frequently in animals that had moved longer distances from their original capture point. During nonepidemic years, the distribution of infection was patchy, and positive foci were mainly located in dense ground vegetation.
Disciplines :
Immunology & infectious disease
Author, co-author :
Escutenaire, Sophie; Pasteur Institute
Chalon, Patrice ; Université de Liège - ULiège > Médecine vétérinaire et santé animale > Immunologie - Vaccinologie
Enria D.A., Briggiler A.M., Pini N., Levis S. (2001) Clinical manifestations of New World hantaviruses. Curr Top Microbiol Immunol 256:117-113.
Linderholm M., Elgh F. (2001) Clinical characteristics of hantavirus infections on the Eurasian continent. Curr Top Microbiol Immunol 256:135-151.
Dournon E., Moriniere B., Matheron S., Girard P.M., Gonzalez J.P., Hirsch F. (1984) HFRS after a wild rodent bite in the Haute-Savoie and risk of exposure to Hantaan-like virus in a Paris laboratory. Lancet 1:676-677.
Yanagihara R., Amyx H.L., Gajdusek D.C. (1985) Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus). J Virol 55:34-38.
Tsai T.F. (1987) Hemorrhagic fever with renal syndrome: Mode of transmission to humans. Lab Anim Sci 37:428-430.
Lee H.W., Lee P.W., Baek L.J., Song C.K., Seong I.W. (1981) Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg 30:1106-1112.
Hutchinson K.L., Rollin P.E., Peters C.J. (1998) Pathogenesis of a North American hantavirus, Black Creek Canal virus, in experimentally infected Sigmodon hispidus. Am J Trop Med Hyg 59:58-65.
Glass G.E., Childs J.E., Korch G.W., LeDuc J.W. (1988) Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus). Epidemiol Infect 101:459-472.
Bernshtein A.D., Apekina N.S., Mikhailova T.V., Myasnikov Y.A., Khlyap L.A., Korotkov Y.S. (1999) Dynamics of Puumala hantavirus infection in naturally infected bank voles (Clethrionomys glareolus). Arch Virol 144:2415-2428.
Mills J.N., Ksiazek T.G., Peters C.J., Childs J.E. (1999) Long-term studies of hantavirus reservoir populations in the Southwestern United States: A synthesis. Emerg Infect Dis 5:135-142.
Hjelle B., Yates T. (2001) Modeling hantavirus maintenance and transmission in rodent communities. Curr Top Microbiol Immunol 256:77-90.
Brummer-Korvenkontio M., Vaheri A., Hovi T., Von Bonsdorff C.H., Vuorimies J., Manni T. (1980) Nephropathia epidemica: Detection of antigen in bank voles and serologic diagnosis of human infection. J Infect Dis 141:131-134.
Gipps J.H.W. (1985) The behaviour of bank voles. Symposium of the Zoological Society of London 55:61-87.
Viitala J., Hoffmeyer I. (1985) Social organization in Clethrionomys compared with Microtus and Apodemus: Social odours, chemistry and biological effects. Ann Zool Fennici 22:359-371.
Gliwicz J. (1989) Individuals and populations of the bank vole in optimal, suboptimal and insular habitats. J Anim Ecol 58:237-247.
Ducoffre G. Surveillance des Maladies Infectieuses par un Réseau de Laboratoires de Microbiologie. Tendances Epidémiologiques 1983-1998, Brussels: Institut Scientifique de la Santé Publique, Section d'Epidémiologie; 1999.
Heyman P., Vervoort T., Escutenaire S., Degrave E., Konings J., Vandenvelde C. (2001) Incidence of hantavirus infections in Belgium. Virus Res 77:71-80.
Escutenaire S., Chalon P., Verhagen R., Heyman P., Thomas I., Karelle-Bui L. (2000) Spatial and temporal dynamics of Puumala hantavirus infection in red bank vole (Clethrionomys glareolus) populations in Belgium. Virus Res 67:91-107.
Mazurkiewicz M. (1983) Spatial organization of the population. Acta Theriol , Petrusewicz K, editor. Ecology of the bank vole; (SUPPL. 1):117-128.
Viitala J., Hakkarainen H., Ylönen H. (1994) Different dispersal in Clethrionomys and Microtus. Ann Zool Fennici 31:411-415.
Brummer-Korvenkontio M., Henttonen H., Vaheri A. (1982) Hemorrhagic fever with renal syndrome in Finland: Ecology and virology of nephropathia epidemica. Scand J Infect Dis Suppl 36:88-91.
Childs J.E., Ksiazek T.G., Spiropoulou C.F., Krebs J.W., Morzunov S., Maupin G.O. (1994) Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis 169:1271-1280.
Stone R. (1993) The mouse-piñon nut connection. Science 262:833.
Young J.C., Mills J.N., Enria D.A., Dolan N.E., Khan A.S., Ksiazek T.G. (1998) New World hantaviruses. Br Med Bull 54:659-673.
Douglass R.J., Van Horn R., Coffin K.W., Zanto S.N. (1996) Hantavirus in Montana deer mouse populations: Preliminary results. J Wildl Dis 32:527-530.
Graham T.B., Chomel B.B. (1997) Population dynamics of the deer mouse (Peromyscus maniculatus) and Sin Nombre virus, California Channel Islands. Emerg Infect Dis 3:367-370.
Mills J.N., Ksiazek T.G., Ellis B.A., Rollin P.E., Nichol S.T., Yates T.L. (1997) Patterns of association with host and habitat: Antibody reactive with Sin Nombre virus in small mammals in the major biotic communities of the southwestern United States. Am J Trop Med Hyg 56:273-284.
Boone J.D., Otteson E.W., McGwire K.C., Villard P., Rowe J.E., St. Jeor S.C. (1998) Ecology and demographics of hantavirus infections in rodent populations in the Walker River Basin of Nevada and California. Am J Trop Med Hyg 59:445-451.
Glass G.E., Livingstone W., Mills J.N., Hlady W.G., Fine J.B., Biggler W. (1998) Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida. Am J Trop Med Hyg 59:699-703.
Abbott K.D., Ksiazek T.G., Mills J.N. (1999) Long-term hantavirus persistence in rodent populations in Central Arizona. Emerg Infect Dis 5:102-112.
Root J.J., Calisher C.H., Beaty B.J. (1999) Relationships of deer mouse movement, vegetative structure, and prevalence of infection with Sin Nombre virus. J Wildl Dis 35:311-318.
Bennett S.G., Webb J.P. Jr., Madon M.B., Childs J.E., Ksiazek T.G., Torrez-Martinez N. (1999) Hantavirus (Bunyaviridae) infections in rodents from Orange and San Diego counties, California. Am J Trop Med Hyg 60:75-84.
Calisher C.H., Sweeney W., Mills J.N., Beaty B.J. (1999) Natural history of Sin Nombre virus in western Colorado. Emerg Infect Dis 5:126-134.
Douglass R.J., Wilson T., Semmens W.J., Zanto S.N., Bond C.W., Van Horn R.C. (2001) Longitudinal studies of Sin Nombre virus in deer mouse-dominated ecosystems of Montana. Am J Trop Med Hyg 65:33-41.
Klein S.L., Bird B.H., Glass G.E. (2001) Sex differences in immune responses and viral shedding following Seoul virus infection in Norway rats. Am J Trop Med Hyg 65:57-63.
Klein S.L., Bird B.H., Glass G.E. (2000) Sex differences in Seoul virus infection are not related to adult sex steroid concentrations in Norway rats. J Virol 74:8213-8217.
Rozenfeld F.M., Le Boulangé E., Rasmont R. (1987) Urine marking by male bank voles (Clethrionomys glareolus Schreber, 1780; Microtidae, Rodentia) in relation to their social rank. Can J Zool 65:2594-2601.
Korch G.W., Childs J.E., Glass G.E., Rossi C.A., LeDuc J.W. (1989) Serologic evidence of hantaviral infections within small mammal communities of Baltimore, Maryland: Spatial and temporal patterns and host range. Am J Trop Med Hyg 41:230-240.
Kuenzi A.J., Morrison M.L., Swann D.E., Hardy P.C., Downard G.T. (1999) A longitudinal study of Sin Nombre virus prevalence in rodents, southeastern Arizona. Emerg Infect Dis 5:113-117.
