Reference : Neuromuscular transmission in migraine: a single-fiber EMG study in clinical subgroups.
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
Neuromuscular transmission in migraine: a single-fiber EMG study in clinical subgroups.
Ambrosini, Anna [> > > >]
Maertens De Noordhout, Alain mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Lippincott Williams & Wilkins
Yes (verified by ORBi)
[en] Action Potentials/physiology ; Adolescent ; Adult ; Analysis of Variance ; Calcium Channels/genetics ; Chi-Square Distribution ; Electromyography/methods ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Migraine with Aura/physiopathology ; Migraine without Aura/physiopathology ; Nerve Fibers/physiology ; Neuromuscular Junction/physiopathology
[en] OBJECTIVE: To search for impairment of neuromuscular transmission by single-fiber electromyography (SFEMG) in patients with common forms of migraine. BACKGROUND: P/Q Ca(2+) channels are genetically abnormal in most cases of familial hemiplegic migraine (International Headache Society [IHS] code 1.2.3) and may be involved in other types of migraine. Besides in the brain, these channels are found in motor nerve endings, where they control stimulation-induced acetylcholine release. If they are functionally abnormal, the neuromuscular transmission might be impaired. METHODS: Sixty-two migraineurs (18 without aura, IHS code 1.1; 19 with typical aura, IHS code 1.2.1; 10 with prolonged aura, IHS code 1.2.2; 15 with and without aura) and 16 healthy control subjects underwent stimulation SFEMG. Results were expressed as the mean value of consecutive differences (MCD) and percentage of single-fiber abnormalities (abnormal jitter or impulse blocking). RESULTS: Average MCD was comparable in control subjects and migraineurs (17.1 +/- 2.6 versus 17.5 +/- 4.7 microsec). By contrast, single-fiber abnormalities were found in 17 patients but in none of the control subjects (p = 0.036). Most of these patients had unilateral sensorimotor symptoms and/or aphasia and/or loss of balance during the aura. SFEMG abnormalities were significantly correlated with the occurrence of these clinical features and with a diagnosis of migraine with prolonged aura. CONCLUSIONS: Stimulation SFEMG shows mild abnormalities of neuromuscular transmission in a subgroup of migraineurs with aura, characterized by clinical features frequently found in human P/Q Ca(2+) channelopathies. These abnormalities might thus be due to genetically modified P/Q Ca(2+) channels.

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