Adult; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Female; Humans; Magnetics; Male; Migraine Disorders/physiopathology; Migraine with Aura/physiopathology; Motor Cortex/physiopathology; Occipital Lobe/physiopathology; Phosphenes/physiology; Sensory Thresholds; Single-Blind Method; Visual Cortex/physiopathology
Abstract :
[en] We used transcranial magnetic stimulation (TMS) with a figure-of-eight coil to excite motor and visual V1-V2 cortices in patients suffering from migraine without (MO) (n = 24) or with aura (MA) (n = 13) and in healthy volunteers (HV) (n = 33). Patients who had a migraine attack within 3 days before or after the recordings were excluded. All females were recorded at mid-cycle. Single TMS pulses over the occipital cortex elicited phosphenes in 64% of HV, 63% of MO and 69% of MA patients. Compared with HV, the phosphene threshold was significantly increased in MO (P = 0.001) and in MA (P = 0.007), but there was no difference between the two groups of migraineurs. The motor threshold tended to be higher in both migraine groups than in HV, but the differences were not significant. In conclusion, this study shows that two-thirds (64.86%) of patients affected by either migraine type present an increased phosphene threshold in the interictal period, which suggests that their visual cortex is hypoexcitable.
Disciplines :
Neurosciences & behavior Neurology
Author, co-author :
Bohotin, V.
Fumal, Arnaud ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Vandenheede, M.
Bohotin, C.
Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Excitability of visual V1-V2 and motor cortices to single transcranial magnetic stimuli in migraine: a reappraisal using a figure-of-eight coil.
Publication date :
2003
Journal title :
Cephalalgia
ISSN :
0333-1024
eISSN :
1468-2982
Publisher :
Blackwell Science, Osney Mead Oxford, United Kingdom
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