[en] Tumor invasion of host tissues and trophoblastic penetration of the endometrium share common biological features. Both processes involve the invasion of basement membranes, an event that is initiated by adhesion of cancer or trophoblast cells to basement membrane components and particularly to laminin. Adhesion to this latter glycoprotein is mediated through a variety of cell surface receptors. We have previously shown that the 67 kD Laminin Receptor (67LR) and a 31 kD Human Laminin Binding Protein, recently renamed galectin-3, are inversely modulated as the invasive phenotype of cancer cells progresses, with up regulation of the former, and down regulation of the latter, respectively. In this study, we examined the expression of these two proteins in 27 human trophoblastic specimens at different gestational ages using Northern and Western blot techniques. Expression of the 67LR increased from 7 weeks to a maximum at 12 weeks, when invasion is maximal, and then decreased. Expression of galectin-3 was inversely modulated by the gestational age, with a minimum expression at 12 weeks. Our data demonstrate that invasive trophoblast displays the same pattern of laminin binding proteins expression than invasive cancer cells, and further demonstrates that invasion of the extracellular matrix by trophoblast and cancer cells share common molecular mechanisms.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Pijnenborg, R., Bland, J., Robertson, W., and Brosens, I. (1983) Placenta. 4:387-414.
Liotta, L.A. (1986) Cancer Res. 46(1):1-7.
Librach, C., Werb, Z., Fitzgerald, M., Chiu, K., Corwin, N., Esteves, R., Grobelny, D., Galardy, R., Damsky, C., and Fisher, S. (1991) J Cell Biol. 113:437-449.
Fernandez, P., Merino, M., Nogales, F., Charonis, A., Stetler-Stevenson, W., and Liotta, L. (1992) Lab Invest. 66(5):572-579.
Wewer, U.M., Taraboletti, G., Sobel, M.E., Albrechtsen, R., and Liotta, L.A. (1987) Cancer Res. 47(21):5691-8.
Cioce, V., Castronovo, V., Shmookler, B., Garbisa, S., Grigioni, W., Liotta, L., and Sobel, M. (1991) J Natl Cancer Inst. 83:29-36.
Castronovo, V., Campo, E., van den Brule, F., Claysmith, A., Cioce, V., Liu, F., Fernandez, P., and Sobel, M. (1992) J Natl Cancer Inst. 84:1161-1169.
Sato, S., and Hughes, R. (1992) J Biol Chem. 267:6983-6990.
Glisin, V., Crkvenjakov, R., and Byus, C. (1974) Biochemistry. 13(12):2633-7.
Wewer, U.M., Liotta, L.A., Jaye, M., Ricca, G.A., Drohan, W.N., Claysmith, A.P., Rao, C.N., Wirth, P., Coligan, J.E., Albrechtsen, R., and et al. (1986) Proc Natl Acad Sci USA. 83(19):7137-41.
Rao, C., Castronovo, V., Schmitt, M., Wewer, U., Claysmith, A., Liotta, L., and Sobel, M. (1989) Biochemistry. 28:7476-7486.
Frigeri, L.G., and Liu, F.T. (1992) J Immunol. 148(3):861-7.
Damsky, C., Fitzgerald, M., and Fisher, S. (1992) J Clin Invest. 89:210-222.
van den Brule, F., Berchuck, A., Bast, R., Liu, F., Gillet, C., Sobel, M., and Castronovo, V. (in press) Eur J Cancer.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.