Article (Scientific journals)
Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)
Biver, E.; Berenbaum, F.; Valdes, A. M. et al.
2019In Ageing Research Reviews, 55
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Keywords :
Dysbiosis; Gut microbiota; Inflammaging; Modern diet; Obesity; Osteoarthritis
Abstract :
[en] The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber and rich in sugar and saturated fats, which promote chronic low-grade inflammation and obesity. Adverse alterations of the gut microbiota (GMB) composition, called microbial dysbiosis, may favor metabolic syndrome and inflammaging, two important components of OA onset and evolution. Considering the burden of OA and the need to define preventive and therapeutic interventions targeting the modifiable components of OA, an expert working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) to review the potential contribution of GMB to OA. Such a contribution is supported by observational or dietary intervention studies in animal models of OA and in humans. In addition, several well-recognized risk factors of OA interact with GMB. Lastly, GMB is a critical determinant of drug metabolism and bioavailability and may influence the response to OA medications. Further research targeting GMB or its metabolites is needed to move the field of OA from symptomatic management to individualized interventions targeting its pathogenesis. © 2019 The Authors
Disciplines :
General & internal medicine
Author, co-author :
Biver, E.;  Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland
Berenbaum, F.;  Sorbonne Université, INSERM CRSA, Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France
Valdes, A. M.;  Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom
Araujo de Carvalho, I.;  Department of Ageing and Life Course, World Health Organization, 20 Avenue Appia, Geneva 27, 1211, Switzerland
Bindels, L. B.;  Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Université Catholique de Louvain, Brussels, Belgium
Brandi, M. L.;  Bone Metabolic Diseases Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
Calder, P. C.;  Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Cherubini, A.;  Geriatria, Accettazione geriatrica e Centro di ricerca per l'invecchiamento, IRCCS INRCA, Ancona, Italy
Cooper, C.;  NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
Dennison, E.;  MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
Franceschi, C.;  Department of Specialty, Diagnostic and Experimental Medicine (DIMES), University of Bologna, Bologna, Italy
Fuggle, N.;  MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
Laslop, A.;  Scientific Office, Austrian Medicines & Medical Devices Agency, Federal Office for Safety in Health Care, Vienna, Austria
Miossec, P.;  Immunogenomics and Inflammation Research Unit, EA 4130, University of Lyon, and Department of Clinical Immunology and Rheumatology, Hospices Civils de Lyon, Lyon, France
Thomas, T.;  Department of Rheumatology, Hôpital Nord, CHU de Saint-Etienne, and INSERM U1059, University of Lyon, Saint-Etienne, France
Tuzun, S.;  Department of Physical Medicine and Rehabilitation, Cerrahpaşa Medical Faculty, Istanbul, University Cerrahpaşa, Istanbul, Turkey
Veronese, N.;  National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy
Vlaskovska, M.;  Medical Faculty, Department of Pharmacology, Medical University Sofia, Sofia, Bulgaria
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Rizzoli, R.;  Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland
More authors (12 more) Less
Language :
English
Title :
Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)
Publication date :
2019
Journal title :
Ageing Research Reviews
ISSN :
1568-1637
eISSN :
1872-9649
Publisher :
Elsevier Ireland Ltd
Volume :
55
Peer reviewed :
Peer Reviewed verified by ORBi
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