cancer; extracellular matrix; adhesion; co-stimulation; T cells; collagen IV; fibronectin
Abstract :
[en] Although T cells infiltrate malignant tumors, the local immune response is usually inefficient and tumors escape destruction. While extracellular matrix proteins strongly costimulate T cell responses in normal individuals, our studies indicate that peripheral blood T cells from cancer patients and tumor infiltrating cells respond poorly or are resistant to stimulative signals mediated by collagen I and IV and fibronectin. Moreover, the adhesive properties of cancer T cells are markedly depressed. Those functional deficiencies are paralleled by variable deficits in integrin and non-integrin T cell receptors for extracellular matrix. Immunotherapy with BCG causes a dramatic but transient increase in T cell: ECM interactions.
Castronovo, Vincenzo ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Stepien-Sopniewska, B.
Grieb, P.
Ryba, M.
Mrowiec, T.
Korczak-Kowalska, G.
Wierzbicki, P.
Matysiak, W.
Dybowska, B.
Language :
English
Title :
Depressed Immune Surveillance against Cancer: Role of Deficient T Cell: Extracellular Matrix Interactions
Publication date :
July 1994
Journal title :
Cell Adhesion and Communication
ISSN :
1061-5385
eISSN :
1026-7883
Publisher :
Taylor & Francis, United Kingdom
Volume :
2
Issue :
3
Pages :
225-33
Peer reviewed :
Peer Reviewed verified by ORBi
Funding number :
BIOMED BMH1-CT92-0520; Warsaw Medical School intramural grants VI/d1 and VIId/11
Funding text :
This work was supported by BIOMED 1 Concerted Action Grant BMH1 CT 920520 from the Commission of European Communities, Brussels, Belgium and Warsaw Medical Schooli ntramuralg rantsV I/d1 and VIId/11
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