Reference : Depressed Immune Surveillance against Cancer: Role of Deficient T Cell: Extracellular...
Scientific journals : Article
Human health sciences : Oncology
Life sciences : Biochemistry, biophysics & molecular biology
Depressed Immune Surveillance against Cancer: Role of Deficient T Cell: Extracellular Matrix Interactions
Gorski, A. [> > > >]
Castronovo, Vincenzo mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >]
Stepien-Sopniewska, B. [> > > >]
Grieb, P. [> > > >]
Ryba, M. [> > > >]
Mrowiec, T. [> > > >]
Korczak-Kowalska, G. [> > > >]
Wierzbicki, P. [> > > >]
Matysiak, W. [> > > >]
Dybowska, B. [> > > >]
Cell Adhesion and Communication
Yes (verified by ORBi)
[en] cancer ; extracellular matrix ; adhesion ; co-stimulation ; T cells ; collagen IV ; fibronectin
[en] Although T cells infiltrate malignant tumors, the local immune response is usually inefficient and tumors escape destruction. While extracellular matrix proteins strongly costimulate T cell responses in normal individuals, our studies indicate that peripheral blood T cells from cancer patients and tumor infiltrating cells respond poorly or are resistant to stimulative signals mediated by collagen I and IV and fibronectin. Moreover, the adhesive properties of cancer T cells are markedly depressed. Those functional deficiencies are paralleled by variable deficits in integrin and non-integrin T cell receptors for extracellular matrix. Immunotherapy with BCG causes a dramatic but transient increase in T cell: ECM interactions.
BIOMED BMH1-CT92-0520 ; Warsaw Medical School intramural grants VI/d1 and VIId/11

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