Reference : First report of probe based confocal laser endomicroscopy during medical thoracoscopy.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/241203
First report of probe based confocal laser endomicroscopy during medical thoracoscopy.
English
BONHOMME, Olivier mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Unité des soins intensifs médicaux >]
DUYSINX, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Oncologie thoracique >]
HEINEN, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie - allergologie >]
DETREMBLEUR, Nancy [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Corhay, Jean-Louis mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Louis, Renaud mailto [Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie >]
18-Jan-2019
Respiratory Medicine
147
72-75
Yes (verified by ORBi)
International
0954-6111
1532-3064
United Kingdom
[en] Malignant mesothelioma ; Optical biopsies ; Pleural carcinomatosis ; Probe based confocal laser endomicroscopy ; Thoracoscopy ; pCLE
[en] Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies"). To the best of our knowledge, this article is the first to present pCLE images during medical thoracoscopy. We present here 3 different patients referred for various health problems. A precise description of pleural cavity pCLE images after intravenous fluorescein injection (a fluorophore) together with corresponding macroscopical and histological studies is performed. This led to the diagnosis of normal pleura in one case, carcinomatous pleuritis in another case and a malignant mesothelioma in the third case. We believe that optical biopsies could help clinicians to make an early diagnosis, thereby allowing rapid therapeutic intervention (talc pleurodesis for example). Furthermore, it could help to guide biopsies when affected zones are not obvious to macroscopic examination. In a near future, new fluorophores could be developed to stain some pathophysiological processes, therapeutic targets, or enzymes activities bringing new insights in endoscopic pleural disease work-up.
http://hdl.handle.net/2268/241203
10.1016/j.rmed.2019.01.006
Copyright (c) 2019. Published by Elsevier Ltd.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
BONHOMME 2019_First report of probe_Respir Med_ppediteur.pdfPublisher postprint857.54 kBRequest copy
Open access
BONHOMME 2019_First report of probe_Respir Med_OCR.pdfAuthor postprint449.71 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.