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13 November 2019
Article (Scientific journals)
First report of probe based confocal laser endomicroscopy during medical thoracoscopy.
BONHOMME, Olivier  ; DUYSINX, Bernard  ; HEINEN, Vincent  et al.
2019 • In Respiratory Medicine, 147, p. 72-75
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Keywords :
Malignant mesothelioma; Optical biopsies; Pleural carcinomatosis; Probe based confocal laser endomicroscopy; Thoracoscopy; pCLE
Abstract :
[en] Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies"). To the best of our knowledge, this article is the first to present pCLE images during medical thoracoscopy. We present here 3 different patients referred for various health problems. A precise description of pleural cavity pCLE images after intravenous fluorescein injection (a fluorophore) together with corresponding macroscopical and histological studies is performed. This led to the diagnosis of normal pleura in one case, carcinomatous pleuritis in another case and a malignant mesothelioma in the third case. We believe that optical biopsies could help clinicians to make an early diagnosis, thereby allowing rapid therapeutic intervention (talc pleurodesis for example). Furthermore, it could help to guide biopsies when affected zones are not obvious to macroscopic examination. In a near future, new fluorophores could be developed to stain some pathophysiological processes, therapeutic targets, or enzymes activities bringing new insights in endoscopic pleural disease work-up.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
BONHOMME, Olivier ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Unité des soins intensifs médicaux
DUYSINX, Bernard ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Oncologie thoracique
HEINEN, Vincent ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie - allergologie
DETREMBLEUR, Nancy ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Corhay, Jean-Louis ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Language :
English
Title :
First report of probe based confocal laser endomicroscopy during medical thoracoscopy.
Publication date :
18 January 2019
Journal title :
Respiratory Medicine
ISSN :
0954-6111
eISSN :
1532-3064
Publisher :
Elsevier, Oxford, United Kingdom
Volume :
147
Pages :
72-75
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2019. Published by Elsevier Ltd.

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