Article (Scientific journals)
Serum levels of hyaluronic acid are associated with COPD severity and predict survival.
Papakonstantinou, Eleni; Bonovolias, Ioannis; Roth, Michael et al.
2019In European Respiratory Journal, 53 (3)
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Abstract :
[en] Hyaluronic acid (HA) and its degradation products play an important role in lung pathophysiology and airway remodelling in chronic obstructive pulmonary disease (COPD).We investigated if HA and its degrading enzyme hyaluronidase (HYAL)-1 are associated with COPD severity and outcome.Serum HA was assessed in a discovery cohort of 80 COPD patients at stable state and exacerbations. HA, HYAL-1 and HYAL-1 enzymatic activity were evaluated at stable state, exacerbations and 4 weeks after exacerbations in 638 COPD patients from the PROMISE validation cohort.In the discovery cohort, serum HA was higher at exacerbations compared with the stable state (p=0.015). In the validation cohort, HA was higher at moderate and severe exacerbations than at baseline (p<0.001), and remained higher after 4 weeks (p<0.001). HA was strongly predictive for overall survival since it was associated with time to death (p<0.001) independently of adjusted Charlson score, annual exacerbation rate and BODE (body mass, airflow obstruction, dyspnoea, exercise capacity) index. Serum HYAL-1 was increased at moderate (p=0.004) and severe (p=0.003) exacerbations, but decreased after 4 weeks (p<0.001). HYAL-1 enzymatic activity at stable state was inversely correlated with FEV1 % pred (p=0.034) and survival time (p=0.017).Serum HA is associated with COPD severity and predicts overall survival. Degradation of HA is associated with airflow limitation and impairment of lung function.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Papakonstantinou, Eleni
Bonovolias, Ioannis
Roth, Michael
Tamm, Michael
Schumann, Desiree
Baty, Florent
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Milenkovic, Branislava
Boersma, Wim
Stieltjes, Bram
Kostikas, Konstantinos
Blasi, Francesco
Aerts, Joachim G.
Rohde, Gernot G. U.
Lacoma, Alicia
Torres, Antoni
Welte, Tobias
Stolz, Daiana
More authors (8 more) Less
Language :
English
Title :
Serum levels of hyaluronic acid are associated with COPD severity and predict survival.
Publication date :
07 March 2019
Journal title :
European Respiratory Journal
ISSN :
0903-1936
eISSN :
1399-3003
Publisher :
European Respiratory Society, United Kingdom
Volume :
53
Issue :
3
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c)ERS 2019.
Available on ORBi :
since 12 November 2019

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