ARIA; Care pathways; Health care transformation; MASK; POLLAR; Rhinitis
Abstract :
[en] Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Bousquet, J. Jean
Schunemann, Holger J.
Togias, Alkis
Erhola, Marina
Hellings, Peter W.
Zuberbier, Torsten
Agache, Ioana
Ansotegui, Ignacio J.
Anto, Josep M.
Bachert, Claus
Becker, Sven
Bedolla-Barajas, Martin
Bewick, Michael
Bosnic-Anticevich, Sinthia
Bosse, Isabelle
Boulet, Louis P.
Bourrez, Jean Marc
Brusselle, Guy
Chavannes, Niels
Costa, Elisio
Cruz, Alvaro A.
Czarlewski, Wienczyslawa
Fokkens, Wytske J.
Fonseca, Joao A.
Gaga, Mina
Haahtela, Tari
Illario, Maddalena
Klimek, Ludger
Kuna, Piotr
Kvedariene, Violeta
Le, L. T. T.
Larenas-Linnemann, Desiree
Laune, Daniel
Lourenco, Olga M.
Menditto, Enrica
Mullol, Joaquin
Okamoto, Yashitaka
Papadopoulos, Nikos
Pham-Thi, Nhan
Picard, Robert
Pinnock, Hilary
Roche, Nicolas
Roller-Wirnsberger, Regina E.
Rolland, Christine
Samolinski, Boleslaw
Sheikh, Aziz
Toppila-Salmi, Sanna
Tsiligianni, Ioanna
Valiulis, Arunas
Valovirta, Erkka
Vasankari, Tuula
Ventura, Maria-Teresa
Walker, Samantha
Williams, Sian
Akdis, Cezmi A.
Annesi-Maesano, Isabella
Arnavielhe, Sylvie
Basagana, Xavier
Bateman, Eric
Bedbrook, Anna
Bennoor, K. S.
Benveniste, Samuel
Bergmann, Karl C.
Bialek, Slawomir
Billo, Nils
Bindslev-Jensen, Carsten
Bjermer, Leif
Blain, Hubert
Bonini, Mateo
Bonniaud, Philippe
Bouchard, Jacques
Briedis, Vitalis
Brightling, Christofer E.
Brozek, Jan
Buhl, Roland
Buonaiuto, Roland
Canonica, Giorgo W.
Cardona, Victoria
Carriazo, Ana M.
Carr, Warner
Cartier, Christine
Casale, Thomas
Cecchi, Lorenzo
Cepeda Sarabia, Alfonso M.
Chkhartishvili, Eka
Chu, Derek K.
Cingi, Cemal
Colgan, Elaine
de Sousa, Jaime Correia
Courbis, Anne Lise
Custovic, Adnan
Cvetkosvki, Biljana
D'Amato, Gennaro
da Silva, Jane
Dantas, Carina
Dokic, Dejand
Dauvilliers, Yves
Dedeu, Antoni
De Feo, Giulia
Devillier, Philippe
Di Capua, Stefania
Dykewickz, Marc
Dubakiene, Ruta
Ebisawa, Motohiro
El-Gamal, Yaya
Eller, Esben
Emuzyte, Regina
Farrell, John
Fink-Wagner, Antjie
Fiocchi, Alessandro
Fontaine, Jean F.
Gemicioglu, Bilun
Schmid-Grendelmeir, Peter
Gamkrelidze, Amiran
Garcia-Aymerich, Judith
Gomez, Maximiliano
Gonzalez Diaz, Sandra
Gotua, Maia
Guldemond, Nick A.
Guzman, Maria-Antonieta
Hajjam, Jawad
O'B Hourihane, John
Humbert, Marc
Iaccarino, Guido
Ierodiakonou, Despo
Illario, Maddalena
Ivancevich, Juan C.
Joos, Guy
Jung, Ki-Suck
Jutel, Marek
Kaidashev, Igor
Kalayci, Omer
Kardas, Przemyslaw
Keil, Thomas
Khaitov, Mussa
Khaltaev, Nikolai
Kleine-Tebbe, Jorg
Kowalski, Marek L.
Kritikos, Vicky
Kull, Inger
Leonardini, Lisa
Lieberman, Philip
Lipworth, Brian
Lodrup Carlsen, Karin C.
Loureiro, Claudia C.
Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, et al. Systems medicine and integrated care to combat chronic noncommu-nicable diseases. Genome Med. 2011; 3(7):43.
Stenberg K, Lauer JA, Gkountouras G, Fitzpatrick C, Stanciole A. Econo-metric estimation of WHO-CHOICE country-specific costs for inpatient and outpatient health service delivery. Cost Eff Resour Alloc. 2018; 16:11.
Crespi-Lofton J, Skelton JB. The growing role of biologics and biosimi-lars in the United States: Perspectives from the APhA Biologics and Bio-similars Stakeholder Conference. J Am Pharm Assoc. 2017; 57(5):e15-27.
Gronde TV, Uyl-de Groot CA, Pieters T. Addressing the challenge of high-priced prescription drugs in the era of precision medicine: a systematic review of drug life cycles, therapeutic drug markets and regulatory frameworks. PLoS ONE. 2017; 12(8):e0182613.
Global Burden of Disease Health Financing Collaborator N. Future and potential spending on health 2015-2040: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries. Lancet. 2017; 389(10083):2005-30.
Russell J, Greenhalgh T. Affordability as a discursive accomplishment in a changing National Health Service. Soc Sci Med. 2012; 75(12):2463-71.
Hunter DJ, Erskine J, Small A, McGovern T, Hicks C, Whitty P, et al. Doing transformational change in the English NHS in the context of "big bang" redisorganisation. J Health Organ Manag. 2015; 29(1):10-24.
Farmanova E, Bonneville L, Bouchard L. Organizational health literacy: review of theories, frameworks, guides, and implementation issues. Inquiry. 2018; 55:46958018757848.
Campbell H, Hotchkiss R, Bradshaw N, Porteous M. Integrated care pathways. BMJ. 1998; 316(7125):133-7.
Hujala A, Taskinen H, Rissanen S. In: Richardson E, van Ginneken E, editors. How to support integration to promote care for people with multi-morbidity in Europe? European Observatory Policy Briefs. Copenhagen (Denmark); 2017.
Palmer K, Marengoni A, Forjaz MJ, Jureviciene E, Laatikainen T, Mammarella F, et al. Multimorbidity care model: recommendations from the consensus meeting of the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the life Cycle (JA-CHRODIS). Health Policy. 2018; 122(1):4-11.
Overill S. A practical guide to care pathways. J Integr Care. 1998; 2: 93-8.
Chisholm-Burns MA, Kim Lee J, Spivey CA, Slack M, Herrier RN, Hall-Lipsy E, et al. US pharmacists' effect as team members on patient care: systematic review and meta-analyses. Med Care. 2010; 48(10):923-33.
Lee JK, Slack MK, Martin J, Ehrman C, Chisholm-Burns M. Geriatric patient care by U.S. pharmacists in healthcare teams: systematic review and meta-analyses. J Am Geriatr Soc. 2013; 61(7):1119-27.
Skypala IJ, de Jong NW, Angier E, Gardner J, Kull I, Ryan D, et al. Promoting and achieving excellence in the delivery of Integrated Allergy Care: the European Academy of Allergy & Clinical Immunology competen-cies for allied health professionals working in allergy. Clin Transl Allergy. 2018; 8:31.
Brozek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010; 126(3):466-76.
Brozek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) Guidelines-2016 revision. J Allergy Clin Immunol. 2017; 140(4):950-8.
Dykewicz MS, Wallace DV, Baroody F, Bernstein J, Craig T, Finegold I, et al. Treatment of seasonal allergic rhinitis: an evidence-based focused 2017 guideline update. Ann Allergy Asthma Immunol. 2017; 119(6):489-511.
Bousquet J, Devillier P, Arnavielhe S, Bedbrook A, Alexis-Alexandre G, van Eerd M, et al. Treatment of allergic rhinitis using mobile technol-ogy with real-world data: The MASK observational pilot study. Allergy. 2018; 73(9):1763-74
Gray WN, Netz M, McConville A, Fedele D, Wagoner ST, Schaefer MR. Medication adherence in pediatric asthma: a systematic review of the literature. Pediatr Pulmonol. 2018; 53(5):668-84.
Bousquet J, Murray R, Price D, Somekh D, Munter L, Phillips J, et al. The allergic allergist behaves like a patient. Ann Allergy Asthma Immunol. 2018; 121(6):741-2.
Bedard A, Basagana X, Anto JM, Garcia-Aymerich J, Devillier P, Arnavielhe S, et al. Mobile technology offers novel insights on control and treatment of allergic rhinitis. The MASK study. J Allergy Clin Immunol. 2019; 144(1):135-143.e6. https://doi.org/10.1016/j.jaci.2019.01.053.
Bateman ED, Reddel HK, O'Byrne PM, Barnes PJ, Zhong N, Keen C, et al. As-needed budesonide-formoterol versus maintenance budesonide in mild asthma. N Engl J Med. 2018; 378(20):1877-87.
O'Byrne PM, FitzGerald JM, Bateman ED, Barnes PJ, Zhong N, Keen C, et al. Inhaled combined budesonide-formoterol as needed in mild asthma. N Engl J Med. 2018; 378(20):1865-76.
Camargos P, Affonso A, Calazans G, Ramalho L, Ribeiro ML, Jentzsch N, et al. On-demand intermittent beclomethasone is effective for mild asthma in Brazil. Clin Transl Allergy. 2018; 8:7.
Levine DMSS, Squires A, Nicholson J, Jay M. Technology-assisted weight loss interventions in primary care: a systematic review. J Gen Intern Med. 2015; 30(1):107-17.
Van der Roest HGWJ, Pastink C, Dröes RM, Orrell M. Assistive technol-ogy for memory support in dementia. Cochrane Database Syst Rev. 2017; 6:CD009627. https://doi.org/10.1002/14651858.cd009627.
Bhattarai PPJ. The role of digital health technologies in management of pain in older people: an integrative review. Arch Gerontol Geriatr. 2017; 68: 14-24.
Hui CY, Walton R, McKinstry B, Jackson T, Parker R, Pinnock H. The use of mobile applications to support self-management for people with asthma: a systematic review of controlled studies to identify features associated with clinical effectiveness and adherence. J Am Med Inform Assoc. 2017; 24(3):619-32.
Bousquet J, Hellings P, Agache I, Amat F, Annesi-Maesano I, Ansotegui I, et al. ARIA Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology. J Allergy Clin Immunol 2018 (in press).
De Greve G, Hellings PW, Fokkens WJ, Pugin B, Steelant B, Seys SF. Endotype-driven treatment in chronic upper airway diseases. Clin Transl Allergy. 2017; 7:22.
Vandenplas O, Vinnikov D, Blanc PD, Agache I, Bachert C, Bewick M, et al. Impact of rhinitis on work productivity: a systematic review. J Allergy Clin Immunol Pract. 2018; 6(4):1274-86.
Amaral R, Fonseca JA, Jacinto T, Pereira AM, Malinovschi A, Janson C, et al. Having concomitant asthma phenotypes is common and inde-pendently relates to poor lung function in NHANES 2007-2012. Clin Transl Allergy. 2018; 8:13.
Cingi C, Gevaert P, Mosges R, Rondon C, Hox V, Rudenko M, et al. Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report. Clin Transl Allergy. 2017; 7:17
Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001; 108(5 Suppl):S147-334.
Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in col-laboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008; 63(suppl 86):8-160.
Bousquet J, Hellings PW, Agache I, Bedbrook A, Bachert C, Bergmann KC, et al. ARIA 2016: Care pathways implementing emerging technolo-gies for predictive medicine in rhinitis and asthma across the life cycle. Clin Transl Allergy. 2016; 6:47.
ARIA in the pharmacy: management of allergic rhinitis symptoms in the pharmacy. Allergic rhinitis and its impact on asthma. Allergy. 2004; 59(4):373-87.
Carr WW, Yawn B P. Management of allergic rhinitis in the era of effective over-the-counter treatments. Postgrad Med. 2017; 129(6):572-80.
Lombardi C, Musicco E, Rastrelli F, Bettoncelli G, Passalacqua G, Canonica GW. The patient with rhinitis in the pharmacy. A cross-sectional study in real life. Asthma Res Pract. 2015; 1(1):4.
Fromer LM, Blaiss MS, Jacob-Nara JA, Long RM, Mannion KM, Lauersen LA. Current Allergic Rhinitis Experiences Survey (CARES): consumers' awareness, attitudes and practices. Allergy Asthma Proc. 2014; 35(4):307-15.
Bousquet J, Neukirch F, Bousquet PJ, Gehano P, Klossek JM, Le Gal M, et al. Severity and impairment of allergic rhinitis in patients consulting in primary care. J Allergy Clin Immunol. 2006; 117(1):158-62.
Bousquet J, Annesi-Maesano I, Carat F, Leger D, Rugina M, Pribil C, et al. Characteristics of intermittent and persistent allergic rhinitis: DREAMS study group. Clin Exp Allergy. 2005; 35(6):728-32
Bousquet PJ, Devillier P, Tadmouri A, Mesbah K, Demoly P, Bousquet J. Clinical relevance of cluster analysis in phenotyping allergic rhinitis in a real-life study. Int Arch Allergy Immunol. 2015; 166(3):231-40.
del Cuvillo A, Montoro J, Bartra J, Valero A, Ferrer M, Jauregui I, et al. Validation of ARIA duration and severity classifications in Spanish allergic rhinitis patients-the ADRIAL cohort study. Rhinology. 2010; 48(2):201-5.
Jauregui I, Davila I, Sastre J, Bartra J, del Cuvillo A, Ferrer M, et al. Validation of ARIA (Allergic Rhinitis and its Impact on Asthma) classification in a pediatric population: the PEDRIAL study. Pediatr Allergy Immunol. 2011; 22(4):388-92.
Adams K, Greiner A, JM JC. The 1st Annual Crossing the Quality Chasm Summit-a Focus on Communities Chapter 5. 2004. https://www.ncbi.nlm.nih.gov/books/NBK215507.
Richard A, Shea K. Delineation of self-care and associated concepts. J Nurs Scholarsh. 2011; 43: 255-64.
Silva DD Helping people help themselves: a review of the evidence considering whether it is worthwhile to support self-management. The Health Foundation 2011. http://www.healthorguk/sites/health/files/HelpingPeopleHelpThemselvespdf. 2011.
Pearce G, Parke H, Pinnock H, Epiphaniou E, Bourne C, Sheikh A, et al. The PRISMS taxonomy of self-management support: derivation of a novel taxonomy and initial testing of utility. J Health Serv Res Policy. 2016; 21: 73-82.
Pinnock H, Effing T, Bourbeau J, van-der-Palen J. Self-management of respiratory disease. Respipedia, the respiratory wiki. 2017. http://respipedia.ers-education.org/article/article/?idTopic=217. Accessed 29 Aug 2017.
Singh D, Ham C. A review of UK and international frameworks. http://www.improvingchroniccareorg/downloads/review-of-international-framework.
Bodenheimer T, Lorig K, Holman H, Grumbach K. Patient self-manage-ment of chronic disease in primary care. JAMA. 2002; 288(19):2469-75.
Hibbard J, Gilburt H. Supporting people to manage their health: an introduction to patient activation. King's Fund 2014. 2014. https://www.kingsfund.org.uk/sites/files/kf/field/field-publication-file/supporting-people-manage-health-patient-activation-may14.pdf.
Mosen D, Schmittdiel J, Hibbard J, Sobel D, Remmers G, Bellows J. Is patient activation associated with outcomes of care for adults with chronic conditions? J Ambul Care Manag. 2007; 30: 21-9.
Hellings PW, Borrelli D, Pietikainen S, Agache I, Akdis C, Bachert C, et al. European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases: report of the European Union Parliament Summit (29 March 2017). Clin Transl Allergy. 2017; 7:49.
Bousquet J, Anto JM, Annesi-Maesano I, Dedeu T, Dupas E, Pepin JL, et al. POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project. Clin Transl Allergy. 2018; 8:36.
Bousquet J, Chavannes NH, Guldemond N, Haahtela T, Hellings PW, Sheikh A. Realising the potential of mHealth to improve asthma and allergy care: how to shape the future. Eur Respir J. 2017. https://doi.org/10.1183/13993003.00447-2017.
Costa C, Menesatti P, Brighetti MA, Travaglini A, Rimatori V, Di Rienzo Businco A, et al. Pilot study on the short-term prediction of symptoms in children with hay fever monitored with e-Health technology. Eur Ann Allergy Clin Immunol. 2014; 46(6):216-25.
Pizzulli A, Perna S, Florack J, Pizzulli A, Giordani P, Tripodi S, et al. The impact of telemonitoring on adherence to nasal corticosteroid treat-ment in children with seasonal allergic rhinoconjunctivitis. Clin Exp Allergy. 2014; 44(10):1246-54.
Bianchi A, Tsilochristou O, Gabrielli F, Tripodi S, Matricardi PM. The smart-phone: a novel diagnostic tool in pollen allergy? J Investig Allergol Clin Immunol. 2016; 26(3):204-7.
Huang X, Matricardi PM. Allergy and Asthma Care in the Mobile Phone Era. Clin Rev Allergy Immunol. 2016.
Bastl K, Berger U, Kmenta M. Evaluation of pollen apps forecasts: the need for quality control in an eHealth service. J Med Internet Res. 2017; 19(5):e152.
Bousquet J, Arnavielhe S, Bedbrook A, Bewick M, Laune D, Mathieu-Dupas E, et al. MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence. Clin Transl Allergy. 2018; 8:45.
Samreth D, Arnavielhe S, Ingenrieth F, Bedbrook A, Onorato GL, Murray R, et al. Geolocation with respect to personal privacy for the Allergy Diary app-a MASK study. World Allergy Organ J. 2018; 11(1):15.
Recital 26-EU GDPR. EU general data protection regulation 2016/679. http://www.privacy-regulation.eu/en/recital-26-GDPR.htm. Accessed 18 Aug 2019
Article 4 EU GDPR. « Definitions ». EU general data protection regulation 2016/679 (GDPR). http://www.privacy-regulation.eu/en/article-4-definitions-GDPR.htm. Accessed 18 Aug 2019
Sullivan PW, Nair KV, Patel BV. The effect of the Rx-to-OTC switch of loratadine and changes in prescription drug benefits on utilization and cost of therapy. Am J Manag Care. 2005; 11(6):374-82.
Rachelefsky G, Farrar JR. Are you comfortable with over-the-counter intranasal steroids for children? A call to action. J Allergy Clin Immunol Pract. 2014; 2(3):271-4.
Carney AS, Price DB, Smith PK, Harvey R, Kritikos V, Bosnic-Anticevich SZ, et al. Seasonal patterns of oral antihistamine and intranasal corticoster-oid purchases from Australian community pharmacies: a retrospective observational study. Pragmat Obs Res. 2017; 8: 157-65.
OTC fluticasone furoate nasal spray (Flonase Sensimist) for allergic rhinitis. Med Lett Drugs Ther. 2017; 59(1519):e70-e1.
Porteous T, Wyke S, Smith S, Bond C, Francis J, Lee AJ, et al. 'Help for Hay Fever', a goal-focused intervention for people with intermittent allergic rhinitis, delivered in Scottish community pharmacies: study protocol for a pilot cluster randomized controlled trial. Trials. 2013; 14:217.
Walls RS, Heddle RJ, Tang ML, Basger BJ, Solley GO, Yeo GT. Optimising the management of allergic rhinitis: an Australian perspective. Med J Aust. 2005; 182(1):28-33.
Smith L, Brown L, Saini B, Seeto C. Strategies for the management of intermittent allergic rhinitis: an Australian study. Health Expect. 2014; 17(2):154-63.
O'Connor J, Seeto C, Saini B, Bosnic-Anticevich S, Krass I, Armour C, et al. Healthcare professional versus patient goal setting in intermittent allergic rhinitis. Patient Educ Couns. 2008; 70(1):111-7.
Smith L, Nguyen T, Seeto C, Saini B, Brown L. The role of non-clinicians in a goal setting model for the management of allergic rhinitis in com-munity pharmacy settings. Patient Educ Couns. 2011; 85(2):e26-32.
Lourenco O, Calado S, Sa-Sousa A, Fonseca J. Evaluation of allergic rhini-This and asthma control in a Portuguese community pharmacy setting. J Manag Care Spec Pharm. 2014; 20(5):513-22.
Kuipers E, Wensing M, de Smet P, Teichert M. Self-management research of asthma and good drug use (SMARAGD study): a pilot trial. Int J Clin Pharm. 2017; 39(4):888-96.
Canonica GW, Triggiani M, Senna G. 360 degree perspective on allergic rhinitis management in Italy: a survey of GPs, pharmacists and patients. Clin Mol Allergy. 2015; 13:25.
Smith P, Price D, Harvey R, Carney AS, Kritikos V, Bosnic-Anticevich SZ, et al. Medication-related costs of rhinitis in Australia: a Nostra-Data cross-sectional study of pharmacy purchases. J Asthma Allergy. 2017; 10: 153-61.
Brozek JL, Akl EA, Alonso-Coello P, Lang D, Jaeschke R, Williams JW, et al. Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions. Allergy. 2009; 64(5):669-77.
Brozek JL, Baena-Cagnani CE, Bonini S, Canonica GW, Rasi G, van Wijk RG, et al. Methodology for development of the Allergic Rhinitis and its Impact on Asthma guideline 2008 update. Allergy. 2008; 63(1):38-46.
Padjas A, Kehar R, Aleem S, Mejza F, Bousquet J, Schunemann HJ, et al. Methodological rigor and reporting of clinical practice guidelines in patients with allergic rhinitis: QuGAR study. J Allergy Clin Immunol. 2014; 133(3):777-83.
Costa DJ, Amouyal M, Lambert P, Ryan D, Schunemann HJ, Daures J P, et al. How representative are clinical study patients with allergic rhinitis in primary care? J Allergy Clin Immunol. 2011; 127(4):920-6.
Parmelli E, Amato L, Oxman AD, Alonso-Coello P, Brunetti M, Moberg J, et al. Grade evidence to decision (EtD) framework for coverage deci-sions. Int J Technol Assess Health Care. 2017; 33(2):176-82.
Schunemann HJ, Mustafa R, Brozek J, Santesso N, Alonso-Coello P, Guyatt G, et al. GRADE Guidelines: 16. GRADE evidence to decision frameworks for tests in clinical practice and public health. J Clin Epidemiol. 2016; 76: 89-98.
Alonso-Coello P, Oxman AD, Moberg J, Brignardello-Petersen R, Akl EA, Davoli M, et al. GRADE Evidence to Decision (EtD) frameworks: a sys-tematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines. BMJ. 2016; 353:i2089.
Schunemann HJ, Hill SR, Kakad M, Vist GE, Bellamy R, Stockman L, et al. Transparent development of the WHO rapid advice guidelines. PLoS Med. 2007; 4(5):e119.
Neumann I, Brignardello-Petersen R, Wiercioch W, Carrasco-Labra A, Cuello C, Akl E, et al. The GRADE evidence-to-decision framework: a report of its testing and application in 15 international guideline panels. Implement Sci. 2016; 11:93.
Pinnock HEE, Pearce G, Parke HL, Greenhalgh T, Sheikh A, Griffths CJ, Taylor SJC Implementing supported self-management for asthma: a systematic review of implementation studies. BMC Med. 2015; 13:127.
Bousquet J, Lund VJ, Van Cauwenberge P, Bremard-Oury C, Mounedji N, Stevens MT, et al. Implementation of guidelines for seasonal allergic rhinitis: a randomized controlled trial. Allergy. 2003; 58(8):733-41.
Bousquet J, Bodez T, Gehano P, Klossek JM, Liard F, Neukirch F, et al. Implementation of guidelines for allergic rhinitis in specialist practices. A randomized pragmatic controlled trial. Int Arch Allergy Immunol. 2009; 150(1):75-82.
Bousquet J, Schünemann H, Togias A, Bachert C, Erhola M, Hellings P, et al. Next-generation ARIA guidelines for allergic rhinitis based on GRADE and real-world evidence. J Allergy Clin Immunol. 2019 (in press).
Bachert C, Bousquet J, Hellings P. Rapid onset of action and reduced nasal hyperreactivity: new targets in allergic rhinitis management. Clin Transl Allergy. 2018; 8:25.
Bousquet J, Hellings PW, Agache I, Amat F, Annesi-Maesano I, Ansotegui IJ, et al. ARIA Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology. J Allergy Clin Immunol. 2018. https://doi.org/10.1016/j.jaci.2018.08.049.
Seys SF, Bousquet J, Bachert C, Fokkens WJ, Agache I, Bernal-Sprekelsen M, et al. mySinusitisCoach: patient empowerment in chronic rhinosi-nusitis using mobile technology. Rhinology. 2018; 56(3):209-15.
Flandroy L, Poutahidis T, Berg G, Clarke G, Dao MC, Decaestecker E, et al. The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems. Sci Total Environ. 2018; 627: 1018-38.
Samolinski B, Fronczak A, Wlodarczyk A, Bousquet J. Council of the European Union conclusions on chronic respiratory diseases in children. Lancet. 2012; 379(9822):e45-6.
Bousquet J, Tanasescu CC, Camuzat T, Anto JM, Blasi F, Neou A, et al. Impact of early diagnosis and control of chronic respiratory diseases on active and healthy ageing. A debate at the European Union Parliament. Allergy. 2013; 68(5):555-61.
Bousquet J, Anto JM, Berkouk K, Gergen P, Antunes J P, Auge P, et al. Developmental determinants in non-communicable chronic diseases and ageing. Thorax. 2015; 70(6):595-7.
Bousquet J, Addis A, Adcock I, Agache I, Agusti A, Alonso A, et al. Inte-grated care pathways for airway diseases (AIRWAYS-ICPs). Eur Respir J. 2014; 44(2):304-23.
Bousquet J, Michel J, Standberg T, Crooks G, Iakovidis I, Gomez M. The European Innovation Partnership on Active and Healthy Ageing: the European Geriatric Medicine introduces the EIP on AHA Column. Eur Geriatr Med. 2014; 5(6):361-2.
Bousquet J, Dahl R, Khaltaev N. Global alliance against chronic respira-tory diseases. Allergy. 2007; 62(3):216-23.
Bousquet J, Barbara C, Bateman E, Bel E, Bewick M, Chavannes NH, et al. AIRWAYS-ICPs (European Innovation Partnership on Active and Healthy Ageing) from concept to implementation. Eur Respir J. 2016; 47(4):1028-33.
Muraro A, Fokkens WJ, Pietikainen S, Borrelli D, Agache I, Bousquet J, et al. European Symposium on Precision Medicine in Allergy and Airways Diseases: report of the European Union Parliament Symposium (October 14, 2015). Allergy. 2016; 71(5):583-7.
Valiulis A, Bousquet J, Veryga A, Suprun U, Sergeenko D, Cebotari S, et al. Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases. Clin Transl Allergy. 2019; 9:7.
