Article (Scientific journals)
Expression of the 67 Kd Laminin Receptor in Human Ovarian Carcinomas as Defined by a Monoclonal Antibody, Mluc5
van den Brule, F. A.; Castronovo, Vincenzo; Menard, S. et al.
1996In European Journal of Cancer, 32A (9), p. 1598-602
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Keywords :
ovarian cancer; laminin receptor; immunohistochemistry
Abstract :
[en] Previous immunohistochemical data from our laboratory have demonstrated that expression of the 67 kD laminin receptor (67LR), a cancer-associated, high-affinity laminin-binding protein, is upregulated in ovarian carcinoma cells compared with normal serosal cells, and that this increased expression in cancer cells could be related to patient outcome. The aim of this study was to validate MLuC5, a monoclonal antibody that recognises the 67LR, as a tool to perform future immunohistochemical studies on larger populations of ovarian carcinoma patients. Expression of the 67LR was determined in 51 primary human ovarian carcinoma samples using immunohistochemistry and MLuC5. The 67LR was detected in ovarian carcinoma cell clusters of variable extent. Analysis of the data determined that 67LR expression was significantly increased in the samples from patients with disease progression, compared with those with no evidence of disease after completion of primary therapy, and in pooled grade 2 and 3 tumours compared to borderline and grade 1 tumours (P < 0.05, chi-squared test). No other significant correlation between 67LR expression and other clinicopathological parameters could be established. These data suggest that the 67LR is correlated to ovarian tumour progression. Detection of the 67LR using this monoclonal antibody could constitute an interesting parameter in prognosis determination of ovarian cancer.
Disciplines :
Oncology
Biochemistry, biophysics & molecular biology
Author, co-author :
van den Brule, F. A.
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Menard, S.
Giavazzi, R.
Marzola, M.
Belotti, D.
Taraboletti, G.
Language :
English
Title :
Expression of the 67 Kd Laminin Receptor in Human Ovarian Carcinomas as Defined by a Monoclonal Antibody, Mluc5
Publication date :
August 1996
Journal title :
European Journal of Cancer
ISSN :
0959-8049
eISSN :
1879-0852
Publisher :
Elsevier, United Kingdom
Volume :
32A
Issue :
9
Pages :
1598-602
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
European BIOMED Conctract BMH1-CT92-0520
Italian Association of Cancer Research (Milano, Italy)
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