Article (Scientific journals)
Memory impairment differs in frontotemporal dementia and Alzheimer's disease
Pasquier, Florence; Grymonprez, Laurence; Lebert, Florence et al.
2001In Neurocase: Case Studies in Neuropsychology, Neuropsychiatry and Behavioural Neurology, 7 (2), p. 161-171
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Keywords :
Alzheimer's disease; Explicit memory; Frontotemporal dementia; Implicit memory
Abstract :
[en] The aim of this study was to assess short-term and long-term explicit memory and implicit memory in frontotemporal dementia (FTD; frontal variant) and to compare FTD and Alzheimer's disease (AD) patients with similar severity of dementia. Fifteen FTD patients [mean age: 68 years; Mini-Mental State (MMS): 24], 30 probable AD patients (mean age: 72 years; MMS: 23) and 12 healthy subjects participated in the study. The three groups were comparable in terms of gender and educational level. Short-term memory was assessed with the digit span and Corsi block-tapping tests. Explicit verbal memory was assessed with the Grober and Buschke test, and implicit memory with a verbal priming task and a fragmented picture test. FTD patients demonstrated a genuine memory deficit with impaired digit span, encoding deficit and retrieval strategy difficulties, but preserved implicit verbal and visual priming. Memory patterns differed in AD and FTD: short-term memory and free recall were similarly decreased in FTD and AD but cues provided more benefit to FTD than to AD; encoding was more impaired and the forgetting rate was faster in AD than in FTD; priming was lower in AD than in FTD. AD patients with clinical and imaging frontal lobe dysfunction tended to have lower memory performance and to differ even more from FTD patients than AD patients without frontal lobe dysfunction.
Disciplines :
Neurosciences & behavior
Author, co-author :
Pasquier, Florence;  University Hospital of Lille
Grymonprez, Laurence;  University Hospital of Lille
Lebert, Florence;  University Hospital of Lille
Van der Linden, Martial ;  Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Language :
English
Title :
Memory impairment differs in frontotemporal dementia and Alzheimer's disease
Publication date :
2001
Journal title :
Neurocase: Case Studies in Neuropsychology, Neuropsychiatry and Behavioural Neurology
ISSN :
1355-4794
eISSN :
1465-3656
Publisher :
Taylor & Francis, United Kingdom
Volume :
7
Issue :
2
Pages :
161-171
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 November 2019

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