Article (Scientific journals)
Extended criteria for liver transplantation in hepatocellular carcinoma. A retrospective, multicentric validation study in Belgium.
Degroote, H; Callebout, E; Samuele, I et al.
2020In Surgical Oncology, 33, p. 231-238
Peer Reviewed verified by ORBi


Full Text
Publisher postprint (1.79 MB)

All documents in ORBi are protected by a user license.

Send to


Keywords :
Alpha-foetoprotein; Asan criteria; Extended transplant criteria; Hepatocellular carcinoma; Metroticket 2.0 model; Up-to-7 criteria; organ transplantation; cancer; Burny
Abstract :
[en] BACKGROUND: Recent studies indicate that a group of patients with cirrhosis receiving a liver transplantation for hepatocellular cancer (HCC) beyond the Milan Criteria (MC) can achieve a similar outcome compared to patients within these criteria. This study aims to investigate the value of the Asan critera (AC), up-to-7 criteria (UT7), French alpha-foetoprotein (AFP) model and Metroticket 2.0 (MT2.0) model compared to the MC. METHODS: 526 patients transplanted for non-metastatic HCC were analyzed. Patient groups within and beyond MC and extended criteria were determined according to radiological assessment and AFP value at listing. RESULTS: Overall survival (OS) and recurrence (RR) rates were similar between patients within MC and all extended criteria. Five-year OS within MC was 71.3% compared to 70.9% for AC, 71.4% for UT7, 69.7% for AFP-model and 71.0% for MT2.0 criteria. Five-year RR within MC was 12.3% compared to 13.5% for AC, 13.0% for UT7, 14.3% for AFP-model and 13.2% for MT2.0 criteria. Patients beyond MC but within the extended criteria had tendency towards higher recurrence. CONCLUSIONS: All validated extended criteria (AC, UT7, AFP-model and MT2.0) could be proposed as alternatives to the MC with similar outcome. Prospective data are awaited to assess recurrence beyond MC.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Degroote, H
Callebout, E
Samuele, I
Dekervel, J
Schreiber, J
Pirenne, J
Verslype, C
ysebaert, D
Michielsen, P
Lucidi, V
Moreno, C
DETRY, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Chirurgie abdo, sénologique, endocrine et de transplantation
Delwaide, Jean ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Troisi, R
Lerut, J
Van Vlierberghe, H
More authors (6 more) Less
Language :
Title :
Extended criteria for liver transplantation in hepatocellular carcinoma. A retrospective, multicentric validation study in Belgium.
Publication date :
June 2020
Journal title :
Surgical Oncology
Publisher :
Elsevier, Netherlands
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2019 Elsevier Ltd. All rights reserved.
Available on ORBi :
since 26 October 2019


Number of views
170 (17 by ULiège)
Number of downloads
248 (12 by ULiège)

Scopus citations®
Scopus citations®
without self-citations


Similar publications

Contact ORBi